Modeling In vivo Wireless Path Loss

Our long-term research goal is to model the in vivo wireless channel. As a first step towards this goal, in this paper we performed in vivo path loss measurements at 2.4GHz and make a comparison with free space path loss. We calculate the path loss by using the electric field radiated by a Hertzian-Dipole located inside the abdominal cavity. The simulations quantify and confirm that the path loss falls more rapidly inside the body than outside the body. We also observe fluctuations of the path loss caused by the inhomogeneity of the human body. In comparison with the path loss measured with monopole antennas, we conclude that the significant variations in Received Signal Strength is caused by both the angular dependent path loss and the significantly modified in vivo antenna effects

MIMO In Vivo

We present the performance of MIMO for in vivo environments, using ANSYS HFSS and their complete human body model, to determine the maximum data rates that can be achieved using an IEEE 802.11n system. Due to the lossy nature of the in vivo medium, achieving high data rates with reliable performance will be a challenge, especially since the in vivo antenna performance is strongly affected by near field coupling to the lossy medium and the signals levels will be limited by specified specific absorption rate (SAR) levels. We analyzed the bit error rate (BER) of a MIMO system with one pair of antennas placed in vivo and the second pair placed inside and outside the body at various distances from the in vivo antennas. The results were compared to SISO simulations and showed that by using MIMO in vivo, significant performance gain can be achieved, and at least two times the data rate can be supported with SAR limited transmit power levels, making it possible to achieve target data rates in the 100 Mbps.Comment: WAMICON 201

A Novel Vectorcardiogram System

This paper presents the proof-of-concept investigation for a miniaturized vectorcardiogram [VCG] system for ambulatory on-body applications that continuously monitors the electrical activity of the heart in three dimensions. We investigate the minimum distance between a pair of leads in the X, Y and Z axes such that the signals are distinguishable from the noise. The target dimensions for our VCG are 3x3x2 cm and, based on our preliminary results, it is possible to achieve these dimensions. The next step in our research is to build the miniaturized VCG system that includes processing, learning and communication capabilities

Microvillar and ciliary defects in zebrafish lacking an actin-binding bioactive peptide amidating enzyme

© The Author(s), 2018. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Scientific Reports 8 (2018): 4547, doi:10.1038/s41598-018-22732-9.The assembly of membranous extensions such as microvilli and cilia in polarized cells is a tightly regulated, yet poorly understood, process. Peptidylglycine α-amidating monooxygenase (PAM), a membrane enzyme essential for the synthesis of amidated bioactive peptides, was recently identified in motile and non-motile (primary) cilia and has an essential role in ciliogenesis in Chlamydomonas, Schmidtea and mouse. In mammalian cells, changes in PAM levels alter secretion and organization of the actin cytoskeleton. Here we show that lack of Pam in zebrafish recapitulates the lethal edematous phenotype observed in Pam−/− mice and reveals additional defects. The pam−/− zebrafish embryos display an initial striking loss of microvilli and subsequently impaired ciliogenesis in the pronephros. In multiciliated mouse tracheal epithelial cells, vesicular PAM staining colocalizes with apical actin, below the microvilli. In PAM-deficient Chlamydomonas, the actin cytoskeleton is dramatically reorganized, and expression of an actin paralogue is upregulated. Biochemical assays reveal that the cytosolic PAM C-terminal domain interacts directly with filamentous actin but does not alter the rate of actin polymerization or disassembly. Our results point to a critical role for PAM in organizing the actin cytoskeleton during development, which could in turn impact both microvillus formation and ciliogenesis.This study was supported by grants DK032949 (to BAE and REM), DK044464 (to JDG) and GM051293 (to SMK) from the National Institutes of Health

Optimizing the Number of Fog Nodes for Cloud-Fog-Thing Networks

Going from theory to practice in fog networking raises the question of the optimum number of fog nodes that will be upgraded from the existing nodes. This paper finds the optimum number of fog nodes for a given total number of ordinary nodes residing in the area of interest for different channel conditions. Determining the optimum number of fog nodes is quite beneficial, because it can strongly affect the SINR, and thus the average data rate and transmission delay. The numerical results indicate that the average data rate increases nearly an order of magnitude for an optimized number of fog nodes in case of shadowing and fading. It is further shown that the optimum number of fog nodes does not increase in direct proportion to the increase in the total number of nodes. Furthermore, the optimum number of fog nodes decreases when channels have high path loss exponents. These findings suggest that the fog nodes must be selected among those that have the highest computation capability for densely deployed networks and high path loss exponents channels

Data and safety monitoring in social behavioral intervention trials: the REACH II experience

Background Psychosocial and behavioral interventions trials targeting a broad range of complex social and behavioral problems such as smoking, obesity and family caregiving have proliferated in the past 30 years. At the same time the use of Data and Safety Monitoring Boards (DSMBs) to monitor the progress and quality of intervention trials and the safety of study participants has increased substantially. Most of the existing literature and guidelines for safety monitoring and reporting of adverse events focuses on medical interventions. Consequently, there is little guidance for investigators conducting social and behavior trials. Purpose This paper summarizes how issues associated with safety monitoring and adverse event reporting were handled in the Resources for Enhancing Alzheimer\u27s Caregiver Health (REACH II) program, a multi-site randomized clinical trial, funded by the National Institutes on Aging (NIA) and the National Institutes of Nursing Research (NINR), that tested the efficacy of a multicomponent social/behavioral intervention for caregivers of persons with Alzheimer\u27s disease. Methods A task force was formed to define adverse events for the trial and protocols for reporting and resolving events that occurred. The task force conducted a review of existing polices and protocols for data and safety monitoring and adverse event reporting and identified potential risks particular to the study population. An informal survey regarding data and safety monitoring procedures with investigators on psychosocial intervention trials was also conducted. Results Two categories of events were defined for both caregivers and patients; adverse events and safety alerts. A distinction was also made between events detected at baseline assessment and those detected post-randomization. Standardized protocols were also developed for the reporting and resolution of events that occurred and training of study personnel. Results from the informal survey indicated wide variability in practices for data safety and monitoring across psychosocial intervention trials. Conclusions Overall, the REACH II experience demonstrates that existing guidelines regarding safety monitoring and adverse event reporting pose unique challenges for social/behavioral intervention trials. Challenges encountered in the REACH II program included defining and classifying adverse events, defining resolution of adverse events and attributing causes for events that occurred. These challenges are highlighted and recommendations for addressing them in future studies are discussed