Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation.

CAPRISA, 2018.Abstract available in pdf

A Comparative Study of Conventional Mammography Film Interpretations with Soft Copy Readings of the Same Examinations

An acceptable mammography film digitizer must provide high-quality images at a level of diagnostic accuracy comparable to reading conventional film examinations. The purpose of this study was to determine if there are significant differences between the interpretations of conventional film-screen mammography examinations and soft copy readings of the images produced by a mammography film digitizer. Eight radiologists interpreted 120 mammography examinations, half as original films and the other half as digital images on a soft copy work station. No radiologist read the same examination twice. The interpretations were recorded in accordance with the Breast Imaging Reporting and Data System and included other variables such as perceived image quality and diagnostic difficulty and confidence. The results provide support for the hypothesis that there are no significant differences between the interpretations of conventional film-screen mammography examinations and soft copy examinations produced by a mammography film digitizer

Using machine learning algorithms to guide rehabilitation planning for home care clients

<p>Abstract</p> <p>Background</p> <p>Targeting older clients for rehabilitation is a clinical challenge and a research priority. We investigate the potential of machine learning algorithms – Support Vector Machine (SVM) and <it>K</it>-Nearest Neighbors (KNN) – to guide rehabilitation planning for home care clients.</p> <p>Methods</p> <p>This study is a secondary analysis of data on 24,724 longer-term clients from eight home care programs in Ontario. Data were collected with the RAI-HC assessment system, in which the Activities of Daily Living Clinical Assessment Protocol (ADLCAP) is used to identify clients with rehabilitation potential. For study purposes, a client is defined as having rehabilitation potential if there was: i) improvement in ADL functioning, or ii) discharge home. SVM and KNN results are compared with those obtained using the ADLCAP. For comparison, the machine learning algorithms use the same functional and health status indicators as the ADLCAP.</p> <p>Results</p> <p>The KNN and SVM algorithms achieved similar substantially improved performance over the ADLCAP, although false positive and false negative rates were still fairly high (FP > .18, FN > .34 versus FP > .29, FN. > .58 for ADLCAP). Results are used to suggest potential revisions to the ADLCAP.</p> <p>Conclusion</p> <p>Machine learning algorithms achieved superior predictions than the current protocol. Machine learning results are less readily interpretable, but can also be used to guide development of improved clinical protocols.</p

Power to the frame: Bringing sociology back to frame analysis

This article critically reviews current frame and framing research in media and communication studies. It is first argued that most authors fail to distinguish between ‘frame’ and ‘framing’ and therewith produce a conceptual confusion and imprecision that is not conducive to the field. Second, it is argued that current frame and framing research ignore sociological research about news production and news audiences that reached its zenith in the 1980s and is still conceptually and methodologically relevant to much current frame and framing research. As a result, a notion of power is absent from most current frame and framing research. By discussing — on the basis of key literature — what a news ‘frame’ is, how it comes about and how it is of consequence successively, these claims are substantiated and research directions for improving the field are indicated

Implantação de um mini-pacs (sistema de arquivamento e distribuição de imagens) em hospital universitário Mini-PACS (picture archiving and communication system) implementation at a university hospital

Este trabalho apresenta a implementação de um mini-PACS (sistema de arquivamento e comunicação de imagens) que está sendo estruturado junto ao Serviço de Radiodiagnóstico do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, como parte do projeto de um serviço de radiologia digital ("filmless").<br>This paper describes the implementation of a mini-PACS (picture archiving and communication system) at a university hospital ("Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo"), as a component of a project for a filmless radiology facility