Revisão de literatura da produção acadêmica brasileira sobre a inserção internacional da China (2000-2022)

O presente trabalho busca traçar o panorama da produção acadêmica nacional sobre a inserção internacional Chinesa, através das perspectivas política, securitária e econômica, indicando os principais temas e resultados convergentes. Além disso, se busca identificar o perfil da academia brasileira, apontando os pólos de publicações, o volume de trabalhos ao longo do tempo e o tipo de pesquisa mais frequente. Como metodologia utilizou-se de análise quali-quantitativa para realizar uma varredura digital no material recolhido, construindo gráficos e nuvens de palavras. Como resultados, encontrou-se uma predominância das regiões Sul e Sudeste no número de trabalhos, um crescimento volumétrico exponencial ao longo do tempo e um maior interesse de pesquisas na ascensão chinesa por meio do desenvolvimento econômico. No eixo político, há a predominância de temas sobre as ações chinesas em instituições internacionais e nas relações Sul-Sul. No eixo securitário, o destaque fica com os teatros de operação na Região da Península Coreana e no Mar do Sul. Por último, o eixo econômico se mostrou o mais evidente, priorizando compreender o peso do mercado chinês e seus efeitos no mundo e na política econômica brasileira.The present study aims to provide an overview of national academic production on China's international insertion, focusing on political, security, and economic perspectives, while indicating the main themes and convergent results. Additionally, the study seeks to identify the profile of Brazilian academia by pointing out the publication poles, the volume of works over time, and the most frequent type of research. Qualitative and quantitative analysis were used as the methodology to conduct a digital scan of the collected material, constructing graphs and word clouds. The results indicate a predominance of the South and Southeast regions in the number of works, exponential growth over time, and a greater interest in research on Chinese ascension through economic development. Regarding the political axis, there is a predominance of themes on Chinese actions in international institutions and in South-South relations. In the security axis, the emphasis is on theaters of operation in the Korean Peninsula region and the South China Sea. Lastly, the economic axis is the most evident, prioritizing an understanding of the weight of the Chinese market and its effects on the world and Brazilian economic policy

Italian digital transformation team: the relevance of the digital awareness

Our research is aimed at highlighting some key elements of the successful path designed by the Italian Digital Transformation Team. With this goal, we propose a qualitative study. The Italian Digital Transformation Team, appointed in September 2016, is made of professionals with specific technical expertise and important managerial skills. Indeed, a proper approach to the digital transformation cannot be based only on the development of technology but it needs the right competencies. As noted by Nadkarni and Prügl (2021), technology and actor are the two aggregate dimensions of digital transformation. Through the analysis of our case study, we emphasize the relevance of the human capital within the digital transformation that, as already pointed out in the literature, is a phenomenon that interests IT evolution as well as processes, people, policies, and leadership of all organizations around the world, regardless type, size, area of business. In order to implement a suitable digital transformation is essential to develop a proper digital awareness: the boundary between opportunity and abyss of digital transformation passes through the digital awareness that is a key element not yet in-depth considered

Circadian sleep propensity and alcohol interaction at the wheel

Study Objectives: The study was aimed at estimating the effect of alcohol consumption, time of day, and their interaction on traffic crashes in a real regional context. Methods: Blood alcohol concentration (BAC) data were collected from drivers involved in traffic accidents during one year in an Italian region and in a control group of drivers over the same road network. Mean circadian sleep propensity was estimated from a previous study as function of time of day. Accident risk was analyzed by logistic regression as function of BAC and circadian sleep propensity. Results: BAC values greater than zero were found in 72.0% of the drivers involved in crashes and in 40.4% of the controls. Among the former 23.6% of the drivers exceeded the BAC legal threshold of 0.05 g/dL, while illegal values were found in 10.4% of the controls. The relative risk showed a significant increase with both BAC and circadian sleep propensity (as estimated from time of day) and their interaction was significant. Conclusions: Due to the significant interaction, even low BAC levels strongly increased accident risk when associated with high sleep propensity

Long Covid: where we stand and challenges ahead

Post-acute sequelae of SARS-CoV-2 (PASC), also known as Post-Covid Syndrome, and colloquially as Long Covid, has been defined as a constellation of signs and symptoms which persist for weeks or months after the initial SARS-CoV-2 infection. PASC affects a wide range of diverse organs and systems, with manifestations involving lungs, brain, the cardiovascular system and other organs such as kidney and the neuromuscular system. The pathogenesis of PASC is complex and multifactorial. Evidence suggests that seeding and persistence of SARS-CoV-2 in different organs, reactivation, and response to unrelated viruses such as EBV, autoimmunity, and uncontrolled inflammation are major drivers of PASC. The relative importance of pathogenetic pathways may differ in different tissue and organ contexts. Evidence suggests that vaccination, in addition to protecting against disease, reduces PASC after breakthrough infection although its actual impact remains to be defined. PASC represents a formidable challenge for health care systems and dissecting pathogenetic mechanisms may pave the way to targeted preventive and therapeutic approaches

Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of the in vitro culture of ovarian cortical tissue strips

: Introduction: We report the development and preliminary evaluation of a novel dynamic bioreactor to culture ovarian cortical tissue strips that leverages tissue response to enhanced oxygen transport and adequate mechanical stimulation. In vitro multistep ovarian tissue static culture followed by mature oocyte generation, fertilization, and embryo transfer promises to use the reserve of dormant follicles. Unfortunately, static in vitro culture of ovarian tissue does not promote development of primordial to secondary follicles or sustain follicle viability and thereby limits the number of obtainable mature oocytes. Enhancing oxygen transport to and exerting mechanical stimulation on ovarian tissue in a dynamic bioreactor may more closely mimic the physiological microenvironment and thus promote follicle activation, development, and viability. Materials and Methods: The most transport-effective dynamic bioreactor design was modified using 3D models of medium and oxygen transport to maximize strip perifusion and apply tissue fluid dynamic shear stresses and direct compressive strains to elicit tissue response. Prototypes of the final bioreactor design were manufactured with materials of varying cytocompatibility and assessed by testing the effect of leachables on sperm motility. Effectiveness of the bioreactor culture was characterized against static controls by culturing fresh bovine ovarian tissue strips for 7 days at 4.8 × 10-5 m/s medium filtration flux in air at -15% maximal total compressive strain and by assessing follicle development, health, and viability. Results and Conclusions: Culture in dynamic bioreactors promoted effective oxygen transport to tissues and stimulated tissues with strains and fluid dynamic shear stresses that, although non-uniform, significantly influenced tissue metabolism. Tissue strip culture in bioreactors made of cytocompatible polypropylene preserved follicle viability and promoted follicle development better than static culture, less so in bioreactors made of cytotoxic ABS-like resin

Effect of fasting on short-term visual plasticity in adult humans

Brain plasticity and function is impaired in conditions of metabolic dysregulation, such as obesity. Less is known on whether brain function is also affected by transient and physiological metabolic changes, such as the alternation between fasting and fed state. Here we asked whether these changes affect the transient shift of ocular dominance that follows short-term monocular deprivation, a form of homeostatic plasticity. We further asked whether variations in three of the main metabolic and hormonal pathways affected in obesity (glucose metabolism, leptin signalling and fatty acid metabolism) correlate with plasticity changes. We measured the effects of 2 h monocular deprivation in three conditions: post-absorptive state (fasting), after ingestion of a standardised meal and during infusion of glucagon-like peptide-1 (GLP-1), an incretin physiologically released upon meal ingestion that plays a key role in glucose metabolism.We found that short-term plasticity was less manifest in fasting than in fed state, whereas GLP-1 infusion did not elicit reliable changes compared to fasting. Although we confirmed a positive association between plasticity and supraphysiological GLP-1 levels, achieved by GLP-1 infusion, we found that none of the parameters linked to glucose metabolism could predict the plasticity reduction in the fasting versus fed state. Instead, this was selectively associated with the increase in plasma beta-hydroxybutyrate (B-OH) levels during fasting, which suggests a link between neural function and energy substrates alternative to glucose. These results reveal a previously unexplored link between homeostatic brain plasticity and the physiological changes associated with the daily fast-fed cycle

The feasibility and test-retest reliability of wireless dry-electrode EEG during a dynamic psychomotor virtual reality task.

Purpose Virtual reality (VR) offers immersive environments for studying psychomotor performance, but the reliability of dry-electrode electroencephalography (EEG) in assessing brain activity during dynamic VR exergames (VRex) remains unclear. The present study investigated the feasibility and reliability of dry-electrode EEG frequency band, with primary focus on alpha band activity. Methods Ten amateur combat sports male participants (37 ± 11 years) volunteered for this study. The feasibility of dry-electrode EEG recording during motion and test-retest (24 h) reliability, was investigated. EEG measurements were obtained pre, post, and throughout a standardized boxing focus ball VRex session, comprising three 3-min rounds interspersed with 1-min rest intervals. EEG data were analyzed globally and at each electrode site, calculating average power spectral density values. Findings ICCs data indicated poor-to-excellent (0.208–0.858) reliability across all measurements within the 4- to 30-Hz frequency range. Poor-to-good reliability (0.393–0.636) was found across the task-active VRex intervals. Electrode sites ranged in reliability from poor (electrode P3; 0.262) to excellent (electrode P4; 0.728), with higher reliability found in the alpha band across electrode sites compared to average spectral band values. Conclusion The present study demonstrates the feasibility, although variable reliability, in neuronal detection during a dynamic VR task, using novel dry-electrode EEG technology

Scientific Status Quo of Small Renal Lesions: Diagnostic Assessment and Radiomics

Background: Small renal masses (SRMs) are defined as contrast-enhanced renal lesions less than or equal to 4 cm in maximal diameter, which can be compatible with stage T1a renal cell carcinomas (RCCs). Currently, 50-61% of all renal tumors are found incidentally. Methods: The characteristics of the lesion influence the choice of the type of management, which include several methods SRM of management, including nephrectomy, partial nephrectomy, ablation, observation, and also stereotactic body radiotherapy. Typical imaging methods available for differentiating benign from malignant renal lesions include ultrasound (US), contrast-enhanced ultrasound (CEUS), computed tomography (CT), and magnetic resonance imaging (MRI). Results: Although ultrasound is the first imaging technique used to detect small renal lesions, it has several limitations. CT is the main and most widely used imaging technique for SRM characterization. The main advantages of MRI compared to CT are the better contrast resolution and tissue characterization, the use of functional imaging sequences, the possibility of performing the examination in patients allergic to iodine-containing contrast medium, and the absence of exposure to ionizing radiation. For a correct evaluation during imaging follow-up, it is necessary to use a reliable method for the assessment of renal lesions, represented by the Bosniak classification system. This classification was initially developed based on contrast-enhanced CT imaging findings, and the 2019 revision proposed the inclusion of MRI features; however, the latest classification has not yet received widespread validation. Conclusions: The use of radiomics in the evaluation of renal masses is an emerging and increasingly central field with several applications such as characterizing renal masses, distinguishing RCC subtypes, monitoring response to targeted therapeutic agents, and prognosis in a metastatic context

The SNAP-tag technology revised: an effective chemo-enzymatic approach by using a universal azide-based substrate

SNAP-tag ® is a powerful technology for the labelling of protein/enzymes by using benzyl-guanine (BG) derivatives as substrates. Although commercially available or ad hoc produced, their synthesis and purification are necessary, increasing time and costs. To address this limitation, here we suggest a revision of this methodology, by performing a chemo-enzymatic approach, by using a BG-substrate containing an azide group appropriately distanced by a spacer from the benzyl ring. The SNAP-tag ® and its relative thermostable version (SsOGT-H5 ) proved to be very active on this substrate. The stability of these tags upon enzymatic reaction makes possible the exposition to the solvent of the azide-moiety linked to the catalytic cysteine, compatible for the subsequent conjugation with DBCO-derivatives by azide-alkyne Huisgen cycloaddition. Our studies propose a strengthening and an improvement in terms of biotechnological applications for this self-labelling protein-tag