Wormlike reverse micelles in lecithin/bile salt/water mixtures in oil

Knowing the ability of water and bile salts to promote the reverse wormlike micelle growth in lecithin/water or lecithin/bile salt mixtures in oil, this work was aimed at elucidating the association properties of the three solutes lecithin, water and the bile salt (BS) sodium deoxycholate in cyclohexane. By systematically changing the fraction of the two additives (i.e.: water and BS) we could identify a region at low additive/lecithin molar ratios where stable wormlike micelle dispersions were formed. Small angle X-ray scattering and oscillatory rheology measurements demonstrated that the ability of bile salt and water to transform the originally spherical lecithin reverse micelles into wormlike micelles and thereby impart to the sample viscoelastic properties is preserved in the three-solute mixture. The results suggest that reverse micelle including both bile salt and water are formed in this system. Reasonably the two primers interact with the same region of the lecithin headgroups and are complementary in altering the packing parameter of the amphiphile to values suitable for the formation of cylindrical aggregates

Skin toxicity after radiotherapy. About a case

A 60-year-old woman was admitted to the Department complaining of a slow growing mass in the right knee. Physical examination demonstrated a mass on the postero-lateral aspect of the right knee, which was not tender or mobile, however was rubbery and hard in consistency. Full flexion and extension was observed without any restriction of joint movement

The Wide-Angle Outflow of the Lensed z = 1.51 AGN HS 0810+2554

We present results from X-ray observations of the gravitationally lensed z = 1.51 AGN HS 0810+2554 performed with the Chandra X-ray Observatory and XMM-Newton. Blueshifted absorption lines are detected in both observations at rest-frame energies ranging between ~1-12 keV at > 99% confidence. The inferred velocities of the outflowing components range between ~0.1c and ~0.4c. A strong emission line at ~6.8 keV accompanied by a significant absorption line at ~7.8 keV is also detected in the Chandra observation. The presence of these lines is a characteristic feature of a P-Cygni profile supporting the presence of an expanding outflowing highly ionized iron absorber in this quasar. Modeling of the P-Cygni profile constrains the covering factor of the wind to be > 0.6, assuming disk shielding. A disk-reflection component is detected in the XMM-Newton observation accompanied by blueshifted absorption lines. The XMM-Newton observation constrains the inclination angle to be < 45 degrees at 90% confidence, assuming the hard excess is due to blurred reflection from the accretion disk. The detection of an ultrafast and wide-angle wind in an AGN with intrinsic narrow absorption lines (NALs) would suggest that quasar winds may couple efficiently with the intergalactic medium and provide significant feedback if ubiquitous in all NAL and BAL quasars. We estimate the mass-outflow rate of the absorbers to lie in the range of 1.5 and 3.4 Msolar/yr for the two observations. We find the fraction of kinetic to electromagnetic luminosity released by HS 0810+2554 is large (epsilon = 9 (-6,+8)) suggesting that magnetic driving is likely a significant contributor to the acceleration of this outflow.Comment: 27 pages, 13 figures, Accepted for publication in Ap

Effect of ionic strength on intra-protein electron transfer reactions: The case study of charge recombination within the bacterial reaction center

It is a common believe that intra-protein electron transfer (ET) involving reactants and products that are overall electroneutral are not influenced by the ions of the surrounding solution. The results presented here show an electrostatic coupling between the ionic atmosphere surrounding a membrane protein (the reaction center (RC) from the photosynthetic bacterium Rhodobacter sphaeroides) and two very different intra-protein ET processes taking place within it. Specifically we have studied the effect of salt concentration on: i) the kinetics of the charge recombination between the reduced primary quinone acceptor QA- and the primary photoxidized donor P+; ii) the thermodynamic equilibrium (QA- ↔ QB-) for the ET between QA- and the secondary quinone acceptor QB. A distinctive point of this investigation is that reactants and products are overall electroneutral. The protein electrostatics has been described adopting the lowest level of complexity sufficient to grasp the experimental phenomenology and the impact of salt on the relative free energy level of reactants and products has been evaluated according to suitable thermodynamic cycles. The ionic strength effect was found to be independent on the ion nature for P+ QA- charge recombination where the leading electrostatic term was the dipole moment. In the case of the QA- ↔ QB- equilibrium, the relative stability of QA- and QB- was found to depend on the salt concentration in a fashion that is different for chaotropic and kosmotropic ions. In such a case both dipole moment and quadrupole moments of the RC must be considered