Ecologic constituent of risk of reproductive complications

Technogenic pressure contributes to the constant emission of significant amounts of chemical pollutants in the environment, thus increasing the risk of ecologically conditioned pathology in the population of urbanized areas. Of the variety of environmental factors that have a detrimental effect on the body of a future mother, cadmium plays a particularly important role as a risk factor for complications in the course of pregnancy. Therefore, the purpose of the research was to determine the influence of external exposures of cadmium on the level of internal contamination of the body of pregnant women and the frequency of manifestation of nephropathy among residents of Dnipropetrovsk region in the complex impact of different levels of environmental pollution. The research program included an assessment of the cadmium content in life-saving environmental facilities and biological substrates of 89 healthy pregnant women, as well as a retrospective analysis of data of the primary statistical documentation on the complication of pregnancy. It is established that cadmium has a constant presence in environmental objects, in concentrations that do not exceed the normative meanings. The level of cadmium in the blood and urine of women in industrial districts is significantly higher in comparison with the control (

CHERNOBYL EXCLUSION ZONE - A WORLD FAMOUS TOURIST BRAND OF UKRAINE

Annotation. The article identifies the main principles of of functioning and development of the tourism in the Chornobyl radiation and ecological biosphere reserveaffected by the technogenic disaster. The paper provides a rationale fortourismdevelopmentto the Chernobyl exclusion zone as anew direction of the international tourism service market.It defines the main principles of planning and development of thebrand of “Chornobyl radiation and ecological biosphere reserve” (Chernobyl exclusion zone) and providesproposals for itspromotion astheworld-famous tourist brand of Ukraineon the international tourism service market through popularisation of the safe tours to Chernobyl exclusion zone.This article examines the important role of the state in the optimization and arrangementof the market participants activity in this region and tourist offers.The study has confirmedthe safety of the proposed tours with the assistance of specialists of the State Agency of Ukraine on the Exclusion Zone Management, the Chornobyl radiation and ecological biosphere reserve, and State specialised enterprise "Ecocentre". This paper proposes a number ofpractical measures in the context of the formation of the renewed Strategy of the Chernobyl exclusion zone development for optimization of the international tourism service marketthat will ensure the highest level of the travel market consumer's interest in purchasing tours to this region of Ukraine.Annotation. The article identifies the main principles of of functioning and development of the tourism in the Chornobyl radiation and ecological biosphere reserveaffected by the technogenic disaster. The paper provides a rationale fortourismdevelopmentto the Chernobyl exclusion zone as anew direction of the international tourism service market.It defines the main principles of planning and development of thebrand of “Chornobyl radiation and ecological biosphere reserve” (Chernobyl exclusion zone) and providesproposals for itspromotion astheworld-famous tourist brand of Ukraineon the international tourism service market through popularisation of the safe tours to Chernobyl exclusion zone.This article examines the important role of the state in the optimization and arrangementof the market participants activity in this region and tourist offers.The study has confirmedthe safety of the proposed tours with the assistance of specialists of the State Agency of Ukraine on the Exclusion Zone Management, the Chornobyl radiation and ecological biosphere reserve, and State specialised enterprise "Ecocentre". This paper proposes a number ofpractical measures in the context of the formation of the renewed Strategy of the Chernobyl exclusion zone development for optimization of the international tourism service marketthat will ensure the highest level of the travel market consumer's interest in purchasing tours to this region of Ukraine

Experience of the using natural sorbents as a preventive food

Увага спеціалістів прикута до різних напрямків до оцінки впливу важких металів (ВМ) на організм людини з метою профілактики негативних наслідків та збереження здоров’я що має особливе значення для населення промислових територій. У зв’язку з тропністю ВМ навколишнього середовища до репродуктивної системі вагітної жінки, проведені складні багатопланові дослідження, які дозволили в натурних умовах Дніпропетровського регіону оцінити застосування біопрофілактики негативного впливу металевого навантаження з використанням пектинвміщуючих харчових добавок. Для проведення пектинопрофілактики за результатами попередніх обстежень було відібрано 40 жінок – мешканок дослідних районів м.Дніпро, у крові яких визначали перевищення концентрацій токсичних металів – свинцю і кадмію відносно існуючих нормативів або на рівні металоносійства (вище 0,2 мкг/мл). Оцінка ефективності застосування пектинопрофілактики негативного впливу ВМ на організм проводилась у вагітних жінок шляхом порівняння даних біомоніторингу, показників порфіринового обміну до і після вживання пектинвмісних добавок – «драже пектинового», виробленого Асоціацією “Сума технологій” м.Київ. Після тритижневого вживання драже пектинового середня концентрація свинцю та кадмію в крові жінок статистично достовірно зменшилась на 25-30%, що спостерігалося у 50-80% обстежених жінок при достовірному посиленні реальної елімінації металів-токсикантів на фоні зниження активності маркеру токсичної дії свинцю – амінолевулінової кислоти. Використання пектинопрофілактики сприяло зниженню вмісту у крові свинцю та кадмію при посиленні їх ренальної елімінації, а також відновленню метаболізму мікроелементів в організмі вагітних, що розцінюється як позитивний результат, якій буде сприятиме підвищенню адаптації жінок в у умовах промислових міст.The attention of specialists is focused on different areas direction of the impact of HM on the human body for the prevention of the negative consequences and preserve health. It is particular importance for the population of industrial territories. Due to the tropism of the HM of the environment to the reproductive system of the pregnant woman, complicated multidimensional research has been carried out. It allowed to assess the use of bioprophylaxis of the negative effects of the metal loading in the Dnipropetrovsk region using pectin-containing nutritional supplements. According to the results of previous surveys or pectin prophylaxis 40 women - residents of the experimental regions of Dnipro city were selected, whose blood levels were determined by the excess of concentrations of toxic metals - lead and cadmium according to current norms or at the level of metal carriers (above 0.2 μg / ml). The estimation of the effectiveness of pectin prophylaxis of the negative effects of VM on the body was carried out in pregnant women by simile of the data of biomonitoring, porphyrin metabolism indices before and after the use of pectin containing additives - "Pectic Pill", produced by the Sumy Technologies Association in Kyiv. After three weeks of taking pectic dragee, the average concentration of lead and cadmium in the blood of women was statistically significantly reduced by 25-30%, which was observed in 50-80% of the examined women with a significant increase in the real elimination of metal-toxicants against the background of decreased activity of the toxic marker of lead - aminolevulinic acid. The use of pectin prophylaxis promoted to decrease the content of lead and cadmium in blood when renal elimination increased and also to repair of metabolism of trace elements in the body of pregnant women. It is regarded as a positive result, which will increase the adaptation of women in the conditions of industrial cities

Between «domestic» and «hidden»: semantics of the adjective heimlîch and its derivatives in Gottfried von Straßburg's «Tristan»

The article is focused on the semantic analysis of the Middle High German adjective heimlîch «domestic», «close», «trusted», «hidden», «secret» and its derivatives in Gottfried von Straßburg's Tristan. The very idea of concealment in medieval literature is well studied, but the lexical side of the issue remains practically neglected. This study examines the etymology of heimlîch and its derivatives and analyses the contexts in which these lexemes are used. The Old High German adjective heimlîh could have the meaning «domestic, native», from which «close, trusted» developed in Middle High German, and only in the XII century the meaning «hidden (from strangers), secret» is found for the first time. In «Tristan», this adjective is mostly used in the meaning of «trusted, close». The noun heimlîсhе derived from it is also mostly used by Gottfried in the sense of «trust, closeness». In both cases, «trust» can be interpreted as the feature of the bond between lovers, which, according to Gottfried, is inherent in true love. The verb heimlîhen in 'Tristan' can mean not only «to become trusted», but also «to make homely». The adverb heimlîche(n), on the opposite, belongs mostly to actions performed in secret. Thus, the use of the adjective heimlîch and its derivatives in «Tristan» reflects the European medieval context, where the «open/public» is opposed not yet to the «private» but to the «non-public/hidden»

Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Background: Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods: ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings: Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation: Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding: UK Medical Research Council and Health Technology Assessment Programme

Логістичний менеджмент у системі управління корпорацією

The article defines the urgency of implementing into the railway corporation of the concept of integrated logistics, logistics management space in the management structure, the hierarchical structure of logistics of corporation, and proposes organizational structure of logistics services. The article noted that the logistics inherent active integrating potential is capable to unite and improve the interaction between such basic functional spheres, as supply, marketing, organization of transportations, sales of services and between subsidiaries of corporation and its structural divisions. The article focused on the fact that the introduction of logistic management system will support the stability of the railway corporations in the market, smoothing intra contradiction between procurement, supply, production, marketing, finance and sales services.В статье определена актуальность внедрения в железнодорожной корпорации концепции интегрированной логистики, место логистического менеджмента в структуре менеджмента корпорации, иерархическая структура логистики корпорации и предложена организационная структура службы логистики. Указано, что логистике присущ активный интегрирующий потенциал, способный объединить и улучшить взаимодействие между такими базовыми функциональными сферами, как поставки, маркетинг, организация перевозок, продажа услуг, и между дочерними предприятиями корпорации и ее структурными подразделениями. Акцентировано внимание на том, что внедрение логистического менеджмента будет способствовать поддержке системной устойчивости железнодорожной корпорации на рынке , сглаживая внутрифирменные противоречия между сферами закупок, поставок, производства, маркетинга, финансов и продажи услуг.У статті визначено актуальність впровадження в залізничній корпорації концепції інтегрованої логістики, місце логістичного менеджменту в системі управління корпорацією, ієрархічну структуру логістики корпорації та запропоновано організаційну структуру служби логістики. Зазначено, що логістиці притаманний активний iнтегруючий пoтенціал, здатний поєднати та поліпшити взаємодію між такими базовими функціональними сферами, як постачання, маркетинг, організація перевезень, продаж послуг, та між дочірніми підприємствами корпорації та її структурними підрозділами. Акцентовано увагу на тому, що впровадження логістичного менеджменту сприятиме підтримці системної стійкості залізничної корпорації на ринку, згладжуючи внутрішньофірмові суперечності між сферами закупівлі, постачання, виробництва, маркетингу, фінансів та продажу послуг

Estabilização da tutela antecipada antecedente de urgência: instrumentos processuais aptos a impedi-la e interpretação da petição inicial: uma análise do Recurso Especial 1.760.966 = Stabilizzazione della tutela sommaria antecedente di urgenza: mezzi procedurali che possano impedirla e la interpretazzione dello atto introduttivo della domanda

The purpose of the article is to find a new solution to the problem of creating psychosocial foundations of occupational health of economic specialists from the standpoint of behavioral economics. Methods. Methodical principles of formation and development of professional health of specialists are distinguished: stages, regularities, dynamics. The Results. The psychosocial specificity of research and the levels of formation and preservation of health of specialists in the economic sphere are revealed. The essence, types, components and criteria of labor protection of specialists of economic sphere are determined. Scientific novelty. The conceptual model of formation and preservation of health of specialists of the economic sphere is offered, which is implemented as a theoretical and methodological strategy of a systematic and holistic process of ensuring the achievement of the result of professional activity. The practical significance. New ideas about a healthy person who responsibly manages his own health and realizes himself in society, the image of a specialist who independently sets the goals of formation and preservation of occupational health, chooses the best ways and means of their achievement.The purpose of the article is to find a new solution to the problem of creating psychosocial foundations of occupational health of economic specialists from the standpoint of behavioral economics. Methods. Methodical principles of formation and development of professional health of specialists are distinguished: stages, regularities, dynamics. The Results. The psychosocial specificity of research and the levels of formation and preservation of health of specialists in the economic sphere are revealed. The essence, types, components and criteria of labor protection of specialists of economic sphere are determined. Scientific novelty. The conceptual model of formation and preservation of health of specialists of the economic sphere is offered, which is implemented as a theoretical and methodological strategy of a systematic and holistic process of ensuring the achievement of the result of professional activity. The practical significance. New ideas about a healthy person who responsibly manages his own health and realizes himself in society, the image of a specialist who independently sets the goals of formation and preservation of occupational health, chooses the best ways and means of their achievement

Психологическое обеспечение профессионального здоровья специалистов экономической сферы

L. Golovkova: ORCID 0000-0001-5473-6644; A. Sheviakov: ORCID 0000-0001-8348-1935EN: The purpose of the article is to find a new solution to the problem of creating psychosocial foundations of occupational health of economic specialists from the standpoint of behavioral economics. Methods. Methodical principles of formation and development of professional health of specialists are distinguished: stages, regularities, dynamics. The Results. The psychosocial specificity of research and the levels of formation and preservation of health of specialists in the economic sphere are revealed. The essence, types, components and criteria of labor protection of specialists of economic sphere are determined. Scientific novelty. The conceptual model of formation and preservation of health of specialists of the economic sphere is offered, which is implemented as a theoretical and methodological strategy of a systematic and holistic process of ensuring the achievement of the result of professional activity. The practical significance. New ideas about a healthy person who responsibly manages his own health and realizes himself in society, the image of a specialist who independently sets the goals of formation and preservation of occupational health, chooses the best ways and means of their achievement.UK: Мета. Метою статті є нове рішення проблеми створення психосоціальних основ професійного здоров’я фахівців економічної сфери з позицій поведінкової економіки. Методика. Виокремлено методичні принципи формування та розвитку професійного здоров'я фахівців: етапи, закономірності, динаміка. Результати. Розкрито психосоціальну специфіку дослідження та рівні сформованості та збереження здоров’я фахівців економічної сфери. Визначено сутність, види, компоненти та критерії охорони праці фахівців економічної сфери. Наукова новизна. Запропоновано концептуальну модель формування та збереження здоров’я фахівців економічної сфери, яка реалізована як теоретико-методологічна стратегія систематичного та цілісного процесу забезпечення досягнення результату професійної діяльності. Практична значимість. Нові уявлення про здорову особистість, яка відповідально керує власним здоров’ям та реалізує себе в суспільстві, імідж фахівця, який самостійно ставить цілі формування та збереження професійного здоров’я, обирає найкращі шляхи та засоби їх досягнення.RU: Цель. Целью статьи является новое решение проблемы создания психосоциальных основ профессионального здоровья специалистов экономической сферы с позиций поведенческой экономики. Методика. Выделены методические принципы формирования и развития профессионального здоровья специалистов: этапы, закономерности, динамика. Результаты. Раскрыто психосоциальную специфику исследования и уровни сформированности и сохранения здоровья специалистов экономической сферы. Определена сущность, виды, компоненты и критерии охраны труда специалистов экономической сферы. Научная новизна. Предложена концептуальная модель формирования и сохранения здоровья специалистов экономической сферы, которая реализована как теоретико-методологическая стратегия систематического и целостного процесса обеспечения достижения результата профессиональной деятельности. Практическая значимость. Новые представления о здоровой личности, ответственном руководстве собственным здоровьем и реализации себя в обществе, имидж специалиста, который самостоятельно ставит цели формирования и сохранения профессионального здоровья, выбирает лучшие пути и средства их достижения

A Goddess for the Second Millennium: Transgression and Transformation in the Hindu Tantric Worship of Tripurasundar?

In religious and secular spaces, rituals structure time and place, distinguish the special from the mundane, and shape individual and communal identities. But what makes rituals endure? Why do some ritual systems vanish, while others thrive? And what allows traditions to adapt to cultural change? Reading tantras and commentaries “against the grain,” as products of historical actors, I have traced the early history of the cult of Tripurasundarī to answer these questions, highlighting innovation and continuity in ritual practice and doctrine. Analyzing the earliest texts relevant to the worship of Tripurasundarī, I find four distinct stages in its early development: the Nityā Cult, the classical or mature cult, the Kashmirian reinterpretation, and the south Indian exegesis. In the Nityā cult, the principal Goddess was surrounded by an unelaborated retinue of subordinate goddesses with Kāmadeva, the god of love, as her consort. The Vāmakeśvarīmata described the ritual configuration of the classical cult, including an addition of a vast retinue of subordinate goddesses within the Śrīcakra, the principal ritual diagram of this tradition. The classical cult also added a new system of tantric (non-Vedic) mantras and mudrās (ritual gestures) and Tripurasundarī became associated with Śiva. In the Yoginīhṛdaya, yogic and meditative practices were grafted onto the existing ritual and mantric system. Thirteenth-century exegetes further adapted this tradition to its new environments by reinterpreting it in light of Śaiva non-dualism and Pratyabhijñā philosophy in Kashmir. In south India, the exotericization and Vedāntization brought the cult of Tripurasundarī into the heart of Hindu temple worship, while the devotional (bhakti) practice of chanting carried its most treasured hymns to the forefront of private religious life. Four factors contributed to this success: the non-threatening and pleasing nature of Tripurasundarī and her associations with love magic; the visually stunning Śrīcakra and the complementary mantra system, both viewed as exceedingly powerful; the tremendous range of practices from external ritual to yogic visualizations built upon a rich foundation of ritual and mantra system; and, finally, a history of creative and skillful exegesis, repeatedly adapting this tradition to its changing environments.2022-08-0