Radiopharmaceutical and clinical aspects of sentinel lymph node procedures in breast cancer patients

Teule, G.J.J. [Promotor]Waard, J.W.D. de [Copromotor

True, false, paranormal, and 'designated'? : a reply to Jenkins

PostprintPeer reviewe

Механізм управління інвестиційною діяльністю на підприємствах харчової промисловості

Статья посвящена исследованию экономического механизма управления инвестиционной деятельностью на предприятиях пищевой промышленности. Проанализировано современное состояние инвестиционного обеспечения отрасли, выделены основные составляющие экономического механизма управления инвестиционной деятельностью, в частности, рычаги государственного регулирования, методологическая, законодательная и информационная базы управления инвестиционной деятельностью. Выделены основные проблемы функционирования эффективного механизма управления и предложены пути их решения.Стаття присвячена дослідженню економічного механізму управління інвестиційною діяльністю на підприємствах харчової промисловості. Проаналізовано сучасний стан інвестиційного забезпечення галузі, виділено основні складові економічного механізму управління інвестиційною діяльністю, зокрема, важелі державного регулювання, методологічна, законодавча і інформаційна бази. Виділено проблеми функціонування ефективного механізму управління і запропоновано шляхи їх подолання.This article is dedicate to researching of economic mechanism of investment activities management on food industry enterprises. Analyzed nowadays conditions of providing of the brunch with investments, marked out the main components of economic mechanism of investment activities management, particularly, leverage of state regulation, methodological, legislative and information bases of investment activities management. Marked out the main problems of functioning effective management mechanism and proposed the ways of their salvations

Synthesis of Meso‐Substituted Subphthalocyanine–Subporphyrin Hybrids: Boron Subtribenzodiazaporphyrins

The first syntheses of hybrid structures that lie between SubPhthalocyanines and SubPorphyrins are reported. The versatile, single-step synthetic protocol uses a preformed aminoisoindolene to provide the bridging methine unit and its substituent, while trialkoxyborates simultaneously act as Lewis acid/template and provider of the apical substituent. Selection of each component therefore allows controlled formation of diverse, differentially functionalised systems. The new hybrids are isolated as robust, pure materials that display intense absorption and emission in the mid-visible region. They are further characterised in solution and solid state by variable temperature NMR spectroscopy and X-ray crystallography respectivel

The effect of homocysteine-lowering with B-vitamins on osteoporotic fractures in patients with cerebrovascular disease: substudy of VITATOPS, a randomised placebo-controlled trial

10.1186/1471-2318-13-88BMC Geriatrics131

Особливості планування інвестиційних проектів з відтворення виробничої потужності збиткових вуглевидобувних підприємств

Розкрито особливості планування інвестиційних проектів з відтворення виробничої потужності на збиткових вуглевидобувних підприємствах. Запропоновано алгоритм розрахунку ефективності інвестиційного проекту. Ключові слова: інвестиції, вугільна галузь, шахта, відтворення потужності, проект, очисний вибій, ефективність, собівартість, термін окупності, дисконтування.Раскрыты особенности планирования инвестиционных проектов по воспроизводству производственной мощности на убыточных угледобывающих предприятиях. Предложен алгоритм расчета эффективности инвестиционного проекта. Ключевые слова: инвестиции, угольная отрасль, шахта, воспроизводство мощности, проект, очистной забой, эффективность, себестоимость, срок окупаемости, дисконтирование.The planning of investment projects on reproduction of production capacity of unprofitable coal-mining enterprises is described. The algorithm for calculating the efficiency of the investment project is offered. Its economic efficiency has been proven. Keywords: investments, coal industry, mine, reproduction of capacity, project, stope, efficiency, prime price, period of recoupment, discounting

An assessment of the Hua Oranga outcome instrument and comparison to other outcome measures in an intervention study with Maori and Pacific people following stroke

The Hua Oranga instrument, developed for Maori people with mental illness, showed good responsiveness and adequate psychometric properties in Maori and Pacific people after stroke. Its simplicity, relative brevity, minimal cost and adequate psychometric properties should favour its use in future studies with both Maori and Pacific people. Suggestions are made for refinements to the measure. These should be tested in a new population before Hua Oranga is recommended for general use in a clinical setting. Abstract Aim Health outcomes research for Maori has been hampered by the lack of adequately validated instruments that directly address outcomes of importance to Maori, framed by a Maori perspective of health. Hua Oranga is an outcome instrument developed for Maori with mental illness that uses a holistic view of Maori health to determine improvements in physical, mental, spiritual and family domains of health. Basic psychometric work for Hua Oranga is lacking. We sought to explore the psychometric properties of the instrument and compare its responsiveness alongside other, more established tools in an intervention study involving Maori and Pacific people following acute stroke. Method Randomised 2x2 controlled trial of Maori and Pacific people following acute stroke with two interventions aimed at facilitating self-directed rehabilitation, and with follow-up at 12 months after randomisation. Primary outcome measures were the Physical Component Summary (PCS) and Mental Component Summary (MCS) of the Short Form 36 (SF36) at 12 months. Hua Oranga was used as a secondary outcome measure for participants at 12 months and for carers and whanau (extended family). Psychometric properties of Hua Oranga were explored using plots and correlation coefficients, principal factors analysis and scree plots. Results 172 participants were randomised, of whom 139 (80.8%) completed follow-up. Of these, 135 (97%) completed the Hua Oranga and 117 (84.2%) completed the PCS and MCS of the SF36. Eighty-nine carers completed the Hua Oranga. Total Hua Oranga scores and PCS improved significantly for one intervention group but not the other. Total Hua Oranga scores for carers improved significantly for both interventions. Total Hua Oranga score correlated moderately with the PCS (correlation coefficient 0.55, p<0.001). Factor analysis suggested that Hua Oranga measures two and not four factors; one 'physical-mental' and one 'spiritual-family'. Conclusion The Hua Oranga instrument, developed for Maori people with mental illness, showed good responsiveness and adequate psychometric properties in Maori and Pacific people after stroke. Its simplicity, relative brevity, minimal cost and adequate psychometric properties should favour its use in future studies with both Maori and Pacific people. Suggestions are made for refinements to the measure. These should be tested in a new population before Hua Oranga is recommended for general use in a clinical setting

Liquid metals as electrodes in polymer light emitting diodes

We demonstrate that liquid metals can be used as cathodes in light emitting diodes (pLEDs). The main difference between the use of liquid cathodes and evaporated cathodes is the sharpness of the metal–polymer interface. Liquid metal cathodes result in significantly sharper metal–organic interfaces than vapor deposited cathodes, due to the high surface energy of the metals. The sharper interface in pLEDs with liquid metal cathodes is observed by neutral impact collision ion scattering spectroscopy and low energy ion scattering spectroscopy measurements. The influence of interface sharpness on device performance was studied by comparing current–voltage-light characteristics of devices with OC1C10 paraphenylenevinylene (PPV) as electroluminescent polymer and indium tin oxide (ITO) as hole injection electrode, and different cathodes. Comparison of devices using a liquid Ga cathode and an evaporated Al cathode showed that light emission for the liquid Ga cathode is two orders of magnitude larger than for the evaporated Al cathode, and that the external light efficiency is increased by an order of magnitude. Since the work function of Ga and Al is nearly the same, the poor performance for evaporated Al LEDs is attributed to the formation of an interfacial layer where Al has diffused into, and reacted with, the PPV. This interfacial layer has poor electrical conduction compared to pure PPV, and contains quenching sites which reduce light emission. Low work function liquid metal cathodes were studied by using liquid Ca and Ba amalgams. The improved performance of liquid amalgam pLEDs is attributed to the different structure of the metal–polymer interface. The enormous increase in light and current through the amalgam devices compared to those using pure Hg demonstrate that less than 1 ML of a metal with a low work function at the polymer-cathode interface can have a dramatic effect on the performance of the devices. Devices with a liquid Ca amalgam cathode showed an increase of the current (by 50%) and brightness (80%) compared to devices with an evaporated Ca cathode, which is ascribed to reduced diffusion of Ca into the emissive PPV laye