Perivascular adipose tissue and inflammation

Comment in: Response to "Perivascular adipose tissue and inflammation. [Obesity (Silver Spring). 2016] Comment on: Disconnect between adipose tissue inflammation and cardiometabolic dysfunction in Ossabaw pigs. [Obesity (Silver Spring). 2015

The Globalization of the Rural Swazi Weaver: Lavumisa Women in the Commercial Handicraft Industry, 1981- 2013

From the Women and Development (WAD) theory perspective, this study explores the development of women’s handicraft industry in Lavumisa, a drought prone area in southeastern Swaziland. Women-dominated handicraft production in Lavumisa occurred within the context of land alienation and male labour migration under colonialism, and later, economic and HIV related problems in post-colonial Swaziland. State controlled marketing of handicraft started in 1962. The prevalence of faith-based non-governmental organizations and the United States Peace Corps during the 1980s witnessed the introduction of women’s group handicraft production as well as the expansion of the handicraft industry. Meanwhile, the economic recession of the 1990s and the HIV related social problems culminated in the increase in female-headed households. The resultant socio-economic problems saw Gone Rural, a women- oriented Non-Governmental Organization (NGO), taking centre stage in facilitating handicraft production through the provision of raw material, training facilities, new international designs and international marketing facilities for the craft wares. Not only were the Lavumisa women incorporated into the international commercial “mass craft”; they experienced a socio-economic transformation where they became household breadwinners and constituted a women’s petty bourgeois class within their community

Understanding the effect of seams on the aerodynamics of an association football

The aerodynamic properties of an association football were measured using a wind tunnel arrangement. A third scale model of a generic football (with seams) was used in addition to a 'mini-football'. As the wind speed was increased, the drag coefficient decreased from 0.5 to 0.2, suggesting a transition from laminar to turbulent behaviour in the boundary layer. For spinning footballs, the Magnus effect was observed and it was found that reverse Magnus effects were possible at low Reynolds numbers. Measurements on spinning smooth spheres found that laminar behaviour led to a high drag coefficient for a large range of Reynolds numbers, and Magnus effects were inconsistent, but generally showed reverse Magnus behaviour at high Reynolds number and spin parameter. Trajectory simulations of free kicks demonstrated that a football that is struck in the centre will follow a near straight trajectory, dipping slightly before reaching the goal, whereas a football that is struck off centre will bend before reaching the goal, but will have a significantly longer flight time. The curving kick simulation was repeated for a smooth ball, which resulted in a longer flight time, due to increased drag, and the ball curving in the opposite direction, due to reverse Magnus effects. The presence of seams was found to encourage turbulent behaviour, resulting in reduced drag and more predictable Magnus behaviour for a conventional football, compared with a smooth ball. © IMechE 2005

Biogenic gas nanostructures as ultrasonic molecular reporters.

Ultrasound is among the most widely used non-invasive imaging modalities in biomedicine, but plays a surprisingly small role in molecular imaging due to a lack of suitable molecular reporters on the nanoscale. Here, we introduce a new class of reporters for ultrasound based on genetically encoded gas nanostructures from microorganisms, including bacteria and archaea. Gas vesicles are gas-filled protein-shelled compartments with typical widths of 45-250 nm and lengths of 100-600 nm that exclude water and are permeable to gas. We show that gas vesicles produce stable ultrasound contrast that is readily detected in vitro and in vivo, that their genetically encoded physical properties enable multiple modes of imaging, and that contrast enhancement through aggregation permits their use as molecular biosensors

Formation of cortical plasticity in older adults following tDCS and motor training

Neurodegeneration accompanies the process of natural aging, reducing the ability to perform functional daily activities. Transcranial direct current stimulation (tDCS) alters neuronal excitability and motor performance; however its beneficial effect on the induction of primary motor cortex (M1) plasticity in older adults is unclear. Moreover, little is known as to whether the tDCS electrode arrangement differentially affects M1 plasticity and motor performance in this population. In a double-blinded, cross-over trial, we compared unilateral, bilateral and sham tDCS combined with visuomotor tracking, on M1 plasticity and motor performance of the non-dominant upper limb, immediately post and 30 min following stimulation. We found (a) unilateral and bilateral tDCS decreased tracking error by 12–22% at both time points; with sham decreasing tracking error by 10% at 30 min only, (b) at both time points, motor evoked potentials (MEPs) were facilitated (38–54%) and short-interval intracortical inhibition was released (21–36%) for unilateral and bilateral conditions relative to sham, (c) there were no differences between unilateral and bilateral conditions for any measure. These findings suggest that tDCS modulated elements of M1 plasticity, which improved motor performance irrespective of the electrode arrangement. The results provide preliminary evidence indicating that tDCS is a safe non-invasive tool to preserve or improve neurological function and motor control in older adults

Combination GLP-1 and Insulin Treatment Fails to Alter Myocardial Fuel Selection Versus Insulin Alone in Type 2 Diabetes

Context Glucagon-like peptide-1 (GLP-1) and the clinically available GLP-1 agonists have been shown to exert effects on the heart. It is unclear whether these effects occur at clinically used doses in vivo in humans, possibly contributing to CVD risk reduction. Objective To determine whether liraglutide at clinical dosing augments myocardial glucose uptake alone or in combination with insulin compared to insulin alone in metformin-treated Type 2 diabetes mellitus. Design Comparison of myocardial fuel utilization after 3 months of treatment with insulin detemir, liraglutide, or combination detemir+liraglutide. Setting Academic hospital Participants Type 2 diabetes treated with metformin plus oral agents or basal insulin. Interventions Insulin detemir, liraglutide, or combination added to background metformin Main Outcome Measures Myocardial blood flow, fuel selection and rates of fuel utilization evaluated using positron emission tomography, powered to demonstrate large effects. Results We observed greater myocardial blood flow in the insulin-treated groups (median[25th, 75th percentile]: detemir 0.64[0.50, 0.69], liraglutide 0.52[0.46, 0.58] and detemir+liraglutide 0.75[0.55, 0.77] mL/g/min, p=0.035 comparing 3 groups and p=0.01 comparing detemir groups to liraglutide alone). There were no evident differences between groups in myocardial glucose uptake (detemir 0.040[0.013, 0.049], liraglutide 0.055[0.019, 0.105], detemir+liraglutide 0.037[0.009, 0.046] µmol/g/min, p=0.68 comparing 3 groups). Similarly there were no treatment group differences in measures of myocardial fatty acid uptake or handling, and no differences in total oxidation rate. Conclusions These observations argue against large effects of GLP-1 agonists on myocardial fuel metabolism as mediators of beneficial treatment effects on myocardial function and ischemia protection

Magnetic Particle Imaging tracks the long-term fate of in vivo neural cell implants with high image contrast.

We demonstrate that Magnetic Particle Imaging (MPI) enables monitoring of cellular grafts with high contrast, sensitivity, and quantitativeness. MPI directly detects the intense magnetization of iron-oxide tracers using low-frequency magnetic fields. MPI is safe, noninvasive and offers superb sensitivity, with great promise for clinical translation and quantitative single-cell tracking. Here we report the first MPI cell tracking study, showing 200-cell detection in vitro and in vivo monitoring of human neural graft clearance over 87 days in rat brain

Spatio-temporal metrics that distinguish plays in field hockey : a pilot study

In team invasion sports, tactical behaviour can be examined using spatio-temporal data, i.e. the position of the players at a given time. A review of the spatio-temporal metrics used in team invasion sports performance analysis indicated that thousands of variations of metrics being used. Information about the distribution of metrics' individual effects can inform us of the best variable-selection method. The aim of this pilot study was to estimate the distribution of strong marginal effects of spatio-temporal metrics of field hockey plays. With institutional ethical approval, the Womens’ and Mens’ gold medal games from the EuroHockey 2015 field hockey tournament were recorded. Best, acceptable and worst-case outcomes for plays were described by 1,837 spatio-temporal metrics. Each metric's marginal effects were estimated using Cramér's V, Mutual Information and the I-score. Values for Cramér's V of 0.2 and 0.4 to mark the boundaries of small, moderate and large effects. Less than 1% of metrics show large effects with > 87% of all metrics showing small effects as per the Cramér's V thresholds. These large effect metrics where all within the 98th percentile of Mutual Information values and within the 96th percentile of the I-score values, which supports the Cramér's V distribution of marginal effects. Therefore, according to the recommendations of Tibshirani (1996), univariate variable-selection methods will be the most appropriate for selecting important metrics