Transfemoral amputation after failure of knee arthroplasty:A nationwide register-based study

Transfemoral amputation is considered the last treatment option for failed knee arthroplasty. The extent to which this procedure is performed is not well known. The purpose of this study was to identify the incidence and causes of amputation following failure of knee arthroplasty in a nationwide population. Methods: Data were extracted from the Danish Civil Registration System, the Danish National Patient Register, and the Danish Knee Arthroplasty Register. With use of individual data linkage, 92,785 primary knee arthroplasties performed from 1997 to 2013 were identified. Of these, 258 were followed by amputation. Hospital records of all identified cases were reviewed. A competing-risk model was used to estimate the cumulative incidence of amputation. Differences in cumulative incidences were analyzed with use of the Gray test. Results: A total of 115 amputations were performed for causes related to failed knee arthroplasty. The 15-year cumulative incidence of amputation was 0.32% (95% confidence interval [CI], 0.23% to 0.48%). The annual incidence of amputation following arthroplasties performed from 1997 to 2002 was 0.025% compared with 0.018% following arthroplasties performed from 2008 to 2013 (p = 0.06). The causes of the amputation were periprosthetic infection in 95 cases (83%), soft-tissue deficiency in 26 (23%), severe bone loss in 21 (18%), extensor mechanism disruption in 11 (10%), intractable pain in 11 (10%), periprosthetic fracture in 10 (9%), and vascular complications in 9 (8%). In 92 (80%) of the cases, there were ≥2 indications for amputation. Conclusions: The cumulative incidence of amputation within 15 years after primary knee arthroplasty was 0.32%, with a tendency toward a decreasing incidence in the last part of the study period.</p

"Hört einmal auf zu plaudern und merkt auf die Predigt." Evangelisch in Regensburg von 1517 bis heute

Am 15.Oktober 1542 wurde erstmals in der Neupfarrkirche das Abendmahl mit Brot und Wein gefeiert und damit die Reformation in der Reichsstadt Regensburg eingeführt. Daneben blieben aber innerhalb der Stadtmauer mehrere katholische Reichsstände bestehen. So wurde Regensburg zum idealen Ort für den Immerwährenden Reichstag und Zufluchtsort für evangelische Glaubensflüchtlinge. Heute steht das konfessionelle Miteinander im Mittelpunkt. Das vorliegende Heft geht zurück auf eine Vortragsreihe der Neupfarr-Kirchengemeinde zum Reformationsjubiläum. Die Autorin ist die Leiterin des Evang.-Luth. Kirchenarchivs Regensburg

On the generalization of agricultural drought classification from climate data

Climate change is expected to increase the likelihood of drought events, with severe implications for food security. Unlike other natural disasters, droughts have a slow onset and depend on various external factors, making drought detection in climate data difficult. In contrast to existing works that rely on simple relative drought indices as ground-truth data, we build upon soil moisture index (SMI) obtained from a hydrological model. This index is directly related to insufficiently available water to vegetation. Given ERA5-Land climate input data of six months with land use information from MODIS satellite observation, we compare different models with and without sequential inductive bias in classifying droughts based on SMI. We use PR-AUC as the evaluation measure to account for the class imbalance and obtain promising results despite a challenging time-based split. We further show in an ablation study that the models retain their predictive capabilities given input data of coarser resolutions, as frequently encountered in climate models

1,2,3,4-Tetra­methyl­cyclo­pent-2-ene-1,4-diol

The title compound, C9H16O2, crystallizes with two mol­ecules in the asymmetric unit. The structure displays inter­molecular O—H⋯O hydrogen bonding

The Renaissance of Non-Aqueous Uranium Chemistry

Prior to the year 2000, non-aqueous uranium chemistry mainly involved metallocene and classical alkyl, amide, or alkoxide compounds as well as established carbene, imido, and oxo derivatives. Since then, there has been a resurgence of the area, and dramatic developments of supporting ligands and multiply bonded ligand types, small-molecule activation, and magnetism have been reported. This Review 1) introduces the reader to some of the specialist theories of the area, 2) covers all-important starting materials, 3) surveys contemporary ligand classes installed at uranium, including alkyl, aryl, arene, carbene, amide, imide, nitride, alkoxide, aryloxide, and oxo compounds, 4) describes advances in the area of single-molecule magnetism, and 5) summarizes the coordination and activation of small molecules, including carbon monoxide, carbon dioxide, nitric oxide, dinitrogen, white phosphorus, and alkanes