Risque et TAL : détection, prévention, gestion. Introduction au 1 er atelier

International audienceThis article is the introduction to the first workshop dedicated to Risk and NLP, addressing theuse of natural language processing methods for the detection, prevention and management of risk.The papers presented during the workshop come from both academic and industrial actors. Theycover the most risk-prone domain such as biomedicine (medicine and pharmacology), chemistryand transportation, but also address more transversal issues of human activity such as professionalenvironments and technical documentation and requirements. The works presented also show thevariety of the processed data (intervention reports, social network communications, academic papers,surveys, technical documentation), the objectives of the analyses (extraction of information relatedto the risk, ambiguity control, documentation checking), and of technical solutions (data collection,corpus analysis, resources development).Nous présentons ici le premier atelier Risque et TAL portant sur les méthodes de traitement automa-tiques des langues pour la détection, la prévention et la gestion des risques. Les travaux présentés dans le cadre de cet atelier sont issus de travaux académiques mais aussi d'applications développées par des acteurs industriels. Ils couvrent les principaux domaines pour lesquels la notion de risque est au centre de préoccupations de par l'ampleur des conséquences à éviter : biomédical (médecine et pharmacologie), chimie et transports, mais abordent aussi des aspects plus transversaux de l'activité humaine, comme les environnements professionnels et les spécifications. Ces différents travaux montrent à la fois la diversité des données visées (retours d'expérience, réseaux sociaux, publications scientifiques, enquêtes, documentation technique), les objectifs des analyses (extraire de l'information liée aux risques, contrôler ou vérifier les ambiguïtés) et les solutions techniques (recueil de données, analyse de corpus, développement de ressources)

Time to AIDS from 1992 to 1999 in HIV-1-Infected Subjects with Known Date of Infection.

To estimate the change in AIDS incubation time during three periods characterized by different availability of antiretroviral treatments, data from the French Hospital Database on HIV of 4702 HIV-1-positive subjects with a documented date of infection were analyzed. Times from seroconversion to AIDS were compared in three periods: period 1 from January 1992 to June 1995 (monotherapy); period 2 from July 1995 to June 1996 (dual therapy); and period 3 from July 1996 to June 1999 (triple therapy). Nonparametric survival analyses were performed to account for staggered entries in the database and during each period. From periods 1 to 3, antiretroviral treatments were initiated earlier after infection, more subjects were treated, and the nature of regimens changed (25.6% of subjects were treated with monotherapy in period 1, 34.6% were treated with dual therapy in period 2, and 53.4% were treated with triple therapy in period 3). Compared with period 1, the relative hazard (RH) of AIDS was 0.31 in period 3 (95% confidence interval [CI]: 0.24-0.39). When comparing period 3 with period 2, the RH of AIDS was 0.36 (CI: 0.29-0.45). Assuming a log normal distribution, the median time to AIDS was estimated as 8.0 years in period 1 (CI: 6.0-10.6), 9.8 years in period 2 (CI: 8.5, 11.2), and 20.0 years in period 3 (CI: 17.1-23.3). This lengthening in time to AIDS from 1992 to 1999 was particularly marked in the period after the introduction of triple therapy, including protease inhibitors

...des conférences enfin disons des causeries... Détection automatique de segments en relation de paraphrase dans les reformulations de corpus oraux.

International audienceNotre travail porte sur la détection automatique des segments en relation de reformulation paraphrastique dans les corpus oraux. L'approche proposée est une approche syntagmatique qui tient compte des marqueurs de reformu-lation paraphrastique et des spécificités de l'oral. Les données de référence sont consensuelles. Une méthode automatique fondée sur l'apprentissage avec les CRF est proposée afin de détecter les segments paraphrasés. Différents descripteurs sont exploités dans une fenêtre de taille variable. Les tests effectués montrent que les segments en relation de paraphrase sont assez difficiles à détecter, surtout avec leurs frontières correctes. Les meilleures moyennes atteignent 0,65 de F-mesure, 0,75 de précision et 0,63 de rappel. Nous avons plusieurs perspectives à ce travail pour améliorer la détection des segments en relation de paraphrase et pour étudier les données depuis d'autres points de vue. Abstract. Our work addresses automatic detection of segments with paraphrastic rephrasing relation in spoken corpus. The proposed approach is syntagmatic. It is based on paraphrastic rephrasing markers and the specificities of the spoken language. The reference data used are consensual. Automatic method based on machine learning using CRFs is proposed in order to detect the segments that are paraphrased. Different descriptors are exploited within a window with various sizes. The tests performed indicate that the segments that are in paraphrastic relation are quite difficult to detect. Our best average reaches up to 0.65 F-measure, 0.75 precision, and 0.63 recall. We have several perspectives to this work for improving the detection of segments that are in paraphrastic relation and for studying the data from other points of view

Repérage de relations sémantiques entre termes : sur la piste de la morphologie dérivationnelle

International audienceNotre travail est consacré au repérage de relations sémantiques entre termes. Dans ce contexte de constitution de terminologies structurées, nous nous intéressons en particulier à l'aide que peut apporter une approche basée sur la morphologie au regard d'autres techniques d'acquisition de relations sémantiques en corpus. Parmi les opérations dont dispose la morphologie, nous exploitons l'affixation et la composition. Nous portons également notre attention sur la supplétion des bases. Nous montrons quelques schémas interprétatifs qui se dégagent et indiquons les relations sémantiques qui sont aptes, alors, d'émerger

Incidence of HIV-related anal cancer remains increased despite long-term combined antiretroviral treatment: results from the french hospital database on HIV.

PURPOSE: To study recent trends in the incidence of anal cancer in HIV-infected patients receiving long-term combined antiretroviral treatment (cART) compared with the general population. PATIENTS AND METHODS: From the French Hospital Database on HIV, we identified 263 cases of invasive anal squamous cell carcinoma confirmed histologically between 1992 and 2008. We compared incidence rates of anal cancer across four calendar periods: 1992-1996 (pre-cART period), 1997-2000 (early cART period), and 2001-2004 and 2005-2008 (recent cART periods). Standardized incidence ratios (SIRs) were calculated by using general population incidence data from the French Network of Cancer Registries. RESULTS: In HIV-infected patients, the hazard ratio (HR) in the cART periods versus the pre-cART period was 2.5 (95% CI, 1.28 to 4.98). No difference was observed across the cART calendar periods (HR, 0.9; 95% CI, 0.6 to 1.3). In 2005-2008, HIV-infected patients compared with the general population had an excess risk of anal cancer, with SIRs of 109.8 (95% CI, 84.6 to 140.3), 49.2 (95% CI, 33.2 to 70.3), and 13.1 (95% CI, 6.8 to 22.8) for men who have sex with men (MSM), other men, and women, respectively. Among patients with CD4 cell counts above 500/μL for at least 2 years, SIRs were 67.5 (95% CI, 41.2 to 104.3) when the CD4 nadir was less than 200/μL for more than 2 years and 24.5 (95% CI, 17.1 to 34.1) when the CD4 nadir was more than 200/μL. CONCLUSION: Relative to that in the general population, the risk of anal cancer in HIV-infected patients is still extremely high, even in patients with high current CD4 cell counts. cART appears to have no preventive effect on anal cancer, particularly in MSM

Recherche d'information médicale pour le patient Impact de ressources terminologiques

National audienceABSTRACT. The right of patients to access their clinical health record is granted by the code of Santé Publique. Yet, this content remain difficult to understand. We propose an experience, in which we use queries defined by patients in order to find relevant documents. We utilise the Indri search engine, based on statistical language modeling and semantic resources. We stress the point related to the terminological variation (e.g. synonyms, abbreviations) to make the link between expert and patient languages. Various combinations of resources and Indri settings are explored, mostly based on query expansion. Our system shows up to 0.7660 P@10 and up to 0.6793 [email protected]ÉSUMÉ. Le droit d'accès au dossier clinique par les patients est inscrit dans le code de Santé Publique. Cependant, ce contenu reste difficile à comprendre. Nous proposons une expérience, où les requêtes des patients sont utilisées pour retrouver les documents pertinents. Nous util-isons le moteur de recherche Indri, basé sur le modèle statistique de la langue, et des ressources sémantiques. L'accent est mis sur la variation terminologique (e.g. synonymes, abréviations) pour faire le lien entre la langue des experts et des patients. Différentes combinaisons de ressources et du paramétrage de Indri sont testées, essentiellement à travers l'expansion des requêtes. Notre système montre jusqu'à 0,7660 de P@10 et 0,6793 de NDCG@10

The use of funnel plots with regression as a tool to visually compare HIV treatment outcomes between centres adjusting for patient characteristics and size: a UK Collaborative HIV Cohort study

OBJECTIVES: A measure used for assessing the effectiveness of HIV care and comparing clinical centres is the proportion of people starting antiretroviral therapy (ART) with viral suppression (VS) after 1 year. We propose a method that adjusts for patients' demographic characteristics, and visually compares this measure between different sites accounting for centre size. METHODS: We analysed viral load measurements for UK Collaborative HIV Cohort (UK CHIC) patients starting ART between 2006 and 2013. We used logistic regression to estimate the proportion with VS after 1 year of ART adjusted for patient mix (in terms of age and a combined gender/ethnicity/acquisition mode variable) and calendar year. We compared outcomes between centres using funnel plots which account for centre size. RESULTS: The overall proportion of the cohort with VS 1 year after starting ART was 90% and increased from 83% to 93% between 2006 and 2013. VS was lower in younger individuals. White men who have sex with men (MSM) had the highest (94%), and black African (81%) and white (82%) heterosexual women the lowest proportions achieving VS. Comparing the unadjusted funnel plot with the adjusted, there were movements of some centres from outside to inside the 95% contour limits, which was largely explained by the patient mix of these centres. CONCLUSIONS: VS 1 year after ART start was associated with demographic characteristics and centre size; therefore, to compare the performances of centres, adjustment for these factors is required. Adjusted funnel plot is an effective tool which accounts for both the demographic characteristics and the centre size. Social factors, rather than treatment decisions within the control of the centres, may drive differences in outcomes