Fray Andrés de Carvajal: un alcantareño, segundo arzobispo de Santo Domingo. Primado de Indias

El artículo presenta la figura de Fray Andrés de Carvajal, misionero franciscano original de Alcántara, representa un ejemplo insigne de la naturaleza evangélica de la Edad de Oro español.The article brings forward the figure of Friar Andrew of Carvajal, a franciscan missionary who comes from Alcántara. He represents a distinguished example of the nature of evangelisation during the Spanish Golden Age

The Prime number theorem for L-functions of elliptic curves with CM

A través de un ejemplo de curva elíptica con CM, definimos L(E,s), su función L asociada. Luego, veremos cómo esta función proviene de un caracter de Hecke, y tras un breve estudio de las funciones L en un contexto general, se probarán resultados que nos conducen finalmente al Teorema del Número Primo para L(E,s).. El objetivo de la tesis es demostrar la distribución en media sobre primos p, de los autovalores del Frobenius en p para una curva eliptica concreta con multiplicación compleja. A partir del numero de puntos sobre cuerpos primos, usando sumas de Jacobi y el caracter sextico se ve la función L como la función asociada a un caracter de Hecke del cuerpo cuadratico imaginario de CM. Después, siguiendo la demostración clasica del número primo, demostrando ecuación funcional y región libre de ceros, se termina la demostración del teorema

Estudio del déficit habitacional de vivienda del barrio Oriente Quiteño, parroquia Eloy Alfaro (provincia de Pichincha)

El presente trabajo de investigación tiene como objetivo examinar las condiciones habitacionales de las personas que habitan el Barrio Oriente Quiteño, busca también caracterizar el entorno en el que se ubican dichas viviendas, identificar si cuentan con los servicios básicos adecuados, áreas verdes apropiadas, calles en buen estado, servicio de salud eficiente, seguridad con equipamiento necesario, espacios suficientes e independientes para cada núcleo de hogar para garantizar su bienestar. El trabajo identifica un conjunto de programas de financiamiento para vivienda y/o mejoramiento de las mismas y los relaciona con la capacidad económica que tienen los moradores del sector. Por último, presenta un conjunto de recomendaciones que podrían ayudar a solucionar los problemas identificados a lo largo de la investigaciónThis research has the aim of analyzing the conditions in which people live (their houses) in “ Oriente Quiteño ” neighborhood . It also is intended to characterize, and describe the environment, conditions and surroundings of those houses to see wether they have the proper basic services, green areas, streets in good conditions, efficient health care service, proper and well equipped crime patrol service, appropriate and independent space for every family and its well- being. This research identifies a set of financing programs for housing (buying) and / or improvements of the houses and analyzes if they are designed according to the economic level of the inhabitants of that community. Finally, This study is intended to present a set of recommendations that could help to solve the problems identified throughout this investigation. So, this is not only an investigation

Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.

Obsessive-compulsive disorder (OCD) is a psychiatric condition characterized by intrusive thoughts and urges and repetitive, intentional behaviors that cause significant distress and impair functioning. The OCD Collaborative Genetics Association Study (OCGAS) is comprised of comprehensively assessed OCD patients with an early age of OCD onset. After application of a stringent quality control protocol, a total of 1065 families (containing 1406 patients with OCD), combined with population-based samples (resulting in a total sample of 5061 individuals), were studied. An integrative analyses pipeline was utilized, involving association testing at single-nucleotide polymorphism (SNP) and gene levels (via a hybrid approach that allowed for combined analyses of the family- and population-based data). The smallest P-value was observed for a marker on chromosome 9 (near PTPRD, P=4.13 × 10(-)(7)). Pre-synaptic PTPRD promotes the differentiation of glutamatergic synapses and interacts with SLITRK3. Together, both proteins selectively regulate the development of inhibitory GABAergic synapses. Although no SNPs were identified as associated with OCD at genome-wide significance level, follow-up analyses of genome-wide association study (GWAS) signals from a previously published OCD study identified significant enrichment (P=0.0176). Secondary analyses of high-confidence interaction partners of DLGAP1 and GRIK2 (both showing evidence for association in our follow-up and the original GWAS study) revealed a trend of association (P=0.075) for a set of genes such as NEUROD6, SV2A, GRIA4, SLC1A2 and PTPRD. Analyses at the gene level revealed association of IQCK and C16orf88 (both P<1 × 10(-)(6), experiment-wide significant), as well as OFCC1 (P=6.29 × 10(-)(5)). The suggestive findings in this study await replication in larger samples

Training for professors at universities

Las instituciones educativas de nivel superior están conformadas por profesionales de diferentes disciplinas, que requieren estar capacitados, para promover la generación del conocimiento y lograr el aprendizaje significativo en el alumno. Actualmente, considerando que la educación está basada en competencias, los profesores deben estar capacitados en el manejo de herramientas tecnológicas, de investigación y en las mismas competencias profesionales. Así mismo, hoy en día los alumnos a los que se enfrenta presentan diferentes tipos de problemáticas, por lo que otra área de capacitación importante es la inteligencia emocional. Esto con la finalidad de brindar una educación de mayor calidadUniversities are conformed by professionals from different disciplines who need to be trained to promote the generation of knowledge and achieve meaningful learning in students. Currently, considering that education is based on educational skills, professors must be trained in the use of technological tools, research and the professional skills. Actually students have to face different kinds of problems, so another important area of training is emotional intelligence, in order to provide higher quality educatio

Whole-genome association analysis of treatment response in obsessive-compulsive disorder.

Up to 30% of patients with obsessive-compulsive disorder (OCD) exhibit an inadequate response to serotonin reuptake inhibitors (SRIs). To date, genetic predictors of OCD treatment response have not been systematically investigated using genome-wide association study (GWAS). To identify specific genetic variations potentially influencing SRI response, we conducted a GWAS study in 804 OCD patients with information on SRI response. SRI response was classified as 'response' (n=514) or 'non-response' (n=290), based on self-report. We used the more powerful Quasi-Likelihood Score Test (the MQLS test) to conduct a genome-wide association test correcting for relatedness, and then used an adjusted logistic model to evaluate the effect size of the variants in probands. The top single-nucleotide polymorphism (SNP) was rs17162912 (P=1.76 × 10(-8)), which is near the DISP1 gene on 1q41-q42, a microdeletion region implicated in neurological development. The other six SNPs showing suggestive evidence of association (P<10(-5)) were rs9303380, rs12437601, rs16988159, rs7676822, rs1911877 and rs723815. Among them, two SNPs in strong linkage disequilibrium, rs7676822 and rs1911877, located near the PCDH10 gene, gave P-values of 2.86 × 10(-6) and 8.41 × 10(-6), respectively. The other 35 variations with signals of potential significance (P<10(-4)) involve multiple genes expressed in the brain, including GRIN2B, PCDH10 and GPC6. Our enrichment analysis indicated suggestive roles of genes in the glutamatergic neurotransmission system (false discovery rate (FDR)=0.0097) and the serotonergic system (FDR=0.0213). Although the results presented may provide new insights into genetic mechanisms underlying treatment response in OCD, studies with larger sample sizes and detailed information on drug dosage and treatment duration are needed

Fascitis eosinofílica. A propósito de 13 casos

Es tracta de la descripció d'una sèrie de 13 pacients amb fascitis eosinofílica diagnosticats en un hospital universitari entre 1989 i 2009. És una síndrome esclerodermiforme que es caracteritza per induració cutània i engruiximent i inflamació de la fàscia profunda. Es descriuen les característiques clíniques, el tractament rebut i l'evolució de 9 homes i 4 dones, amb una edat mitjana de 50 anys. Es va realitzar biòpsia profunda en tots els casos i els canvis van ser compatibles amb fascitis eosinofílica. Les característiques descrites en aquesta sèrie no difereixen de les descrites per altres autors.Se trata de la descripción de una serie de 13 pacientes con fascitis eosinofílica diagnosticados en un hospital universitario entre 1989 y 2009. Es un síndrome esclerodermiforme que se caracteriza por induración cutánea y engrosamiento e inflamación de la fascia profunda. Se describen las características clínicas, el tratamiento recibido y la evolución de 9 hombres y 4 mujeres cuya edad media era de 50 años. Se realizó biopsia profunda en todos los casos y los cambios fueron compatibles con fascitis eosinofílica. Las características descritas en la presente serie no difieren de las de otros autores

Virtual Antenna™ for Open-Source Hardware Platforms: IoT Smart-Tracking Applications

In this project it has been searched a headliner IoT device and then, studied the applications and the bands which could be covered with a Virtual AntennaTMfrom Fractus Antennas Technology embedded into the selected device. To achieve the main goal,first it has been defined theoperating bands compatible with the chosen deviceneeded to cover. Once the device and the frequency range to cover have been decided it has been studied various scenarios contemplating diverse antennas and designs.The searched of the final solution it has had as a first step the electromagnetic simulation of a lot of set-upswhich it helped to focalize in one direction and then, the physically implementation of the best performance set-ups simulated has been done in order to choose the better set-upfor theembedding. The conclusions obtained as a result of the study will allow to have an idea of the Virtual AntennaTMperformance in an already commercialized deviceand the process to follow when the implementing of an embedded antenna is wanted in a small IoT device

Rare Copy Number Variants in \u3cem\u3eNRXN1\u3c/em\u3e and \u3cem\u3eCNTN6\u3c/em\u3e Increase Risk for Tourette Syndrome

Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (\u3c 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an enrichment of global CNV burden that was prominent for large (\u3e 1 Mb), singleton events (OR = 2.28, 95% CI [1.39–3.79], p = 1.2 × 10−3) and known, pathogenic CNVs (OR = 3.03 [1.85–5.07], p = 1.5 × 10−5). We also identified two individual, genome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 20.3, 95% CI [2.6–156.2]; CNTN6 duplications, OR = 10.1, 95% CI [2.3–45.4]). Approximately 1% of TS cases carry one of these CNVs, indicating that rare structural variation contributes significantly to the genetic architecture of TS