Quantum fluctuations on a thick de Sitter brane

We investigate quantum fluctuations on a de Sitter (dS) brane, which has its own thickness, in order to examine whether or not the finite thickness of the brane can act as a natural cut-off for the Kaluza-Klein (KK) spectrum. We calculate the amplitude of the KK modes and the bound state by using the zeta function method after a dimensional reduction.We show that the KK amplitude is finite for a given brane thickness and in the thin wall limit the standard surface divergent behavior is recovered. The strength of the divergence in the thin wall limit depends on the number of dimensions, e.g., logarithmic on a two dimensional brane and quadratic on a four dimensional brane. We also find that the amplitude of the bound state mode and KK modes depends on the choice of renormalization scale; and for fixed renormalization scales the bound state mode is insensitive to the brane thickness both for two and four-dimensional dS branes.Comment: 23 pages, typos correcte

Pupil light reflex evoked by light-emitting diode and computer screen: methodology and association with need for recovery in daily life

Objectives: Pupil light reflex (PLR) has been widely used as a method for evaluating parasympathetic activity. The first aim of the present study is to develop a PLR measurement using a computer screen set-up and compare its results with the PLR generated by a more conventional setup using light-emitting diode (LED). The parasympathetic nervous system, which is known to control the ‘rest and digest’ response of the human body, is considered to be associated with daily life fatigue. However, only few studies have attempted to test the relationship between self-reported daily fatigue and physiological measurement of the parasympathetic nervous system. Therefore, the second aim of this study was to investigate the relationship between daily-life fatigue, assessed using the Need for Recovery scale, and parasympathetic activity, as indicated by the PLR parameters. Design: A pilot study was conducted first to develop a PLR measurement set-up using a computer screen. PLRs evoked by light stimuli with different characteristics were recorded to confirm the influence of light intensity, flash duration, and color on the PLRs evoked by the system. In the subsequent experimental study, we recorded the PLR of 25 adult participants to light flashes generated by the screen set-up as well as by a conventional LED set-up. PLR parameters relating to parasympathetic and sympathetic activity were calculated from the pupil responses. We tested the split-half reliability across two consecutive blocks of trials, and the relationships between the parameters of PLRs evoked by the two set-ups. Participants rated their need for recovery prior to the PLR recordings. Results: PLR parameters acquired in the screen and LED set-ups showed good reliability for amplitude related parameters. The PLRs evoked by both set-ups were consistent, but showed systematic differences in absolute values of all parameters. Additionally, higher need for recovery was associated with faster and larger constriction of the PLR. Conclusions: This study assessed the PLR generated by a computer screen and the PLR generated by a LED. The good reliability within set-ups and the consistency between the PLRs evoked by the set-ups indicate that both systems provides a valid way to evoke the PLR. A higher need for recovery was associated with faster and larger constricting PLRs, suggesting increased levels of parasympathetic nervous system activity in people experiencing higher levels of need for recovery on a daily basis

Unilateral versus bilateral hearing aids for bilateral hearing impairment in adults

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of bilateral versus unilateral hearing aids in adults with a bilateral hearing impairment

Predictors of entering a hearing aid evaluation period: a prospective study in older hearing-help seekers

This study aimed to determine the predictors of entering a hearing aid evaluation period (HAEP) using a prospective design drawing on the health belief model and the transtheoretical model. In total, 377 older persons who presented with hearing problems to an ENT-specialist (n = 110) or a hearing aid dispenser (n = 267) filled in a baseline questionnaire. After four months, it was determined via a telephone interview whether or not participants had decided to enter a HAEP. Multivariable logistic regression analyses were applied to determine which baseline variables predicted HAEP status. A priori, candidate predictors were divided into ‘likely’ and ‘novel’ predictors based on the literature. The following variables turned out to be significant predictors: more expected hearing aid benefits, greater social pressure, and greater self-reported hearing disability. In addition, greater hearing loss severity and stigma were predictors in women but not in men. Of note, the predictive effect of self-reported hearing disability was modified by readiness such that with higher readiness, the positive predictive effect became stronger. None of the ‘novel’ predictors added significant predictive value. The results support the notion that predictors of hearing aid uptake are also predictive of entering a HAEP. This study shows that some of these predictors appear to be gender-specific or are dependent on a person’s readiness for change. After assuring the external validity of the predictors, an important next step would be to develop prediction rules for use in clinical practice, so that older persons’ hearing help seeking journey can be facilitated

A role for OCRL in glomerular function and disease

Background: Lowe syndrome and Dent-2 disease are caused by mutations in the OCRL gene, which encodes for an inositol 5-phosphatase. The renal phenotype associated with OCRL mutations typically comprises a selective proximal tubulopathy, which can manifest as Fanconi syndrome in the most extreme cases.Methods: Here, we report a 12-year-old male with nephrotic-range proteinuria and focal segmental glomerulosclerosis on renal biopsy. As a glomerular pathology was suspected, extensive investigation of tubular function was not performed.Results: Surprisingly, whole exome sequencing identified a genetic variant in OCRL (c1467-2A&gt;G) that introduced a novel splice mutation leading to skipping of exon 15. In situ hybridisation of adult human kidney tissue and zebrafish larvae showed OCRL expression in the glomerulus, supporting a role for OCRL in glomerular function. In cultured podocytes, we found that OCRL associated with the linker protein IPIP27A and CD2AP, a protein that is important for maintenance of the podocyte slit diaphragm.Conclusion: Taken together, this work suggests a previously under-appreciated role for OCRL in glomerular function and highlights the importance of investigating tubular function in patients with persistent proteinuria.</p

Impact of stimulus-related factors and hearing impairment on listening effort as indicated by pupil dilation

Previous research has reported effects of masker type and signal-to-noise ratio (SNR) on listening effort, as indicated by the peak pupil dilation (PPD) relative to baseline during speech recognition. At about 50% correct sentence recognition performance, increasing SNRs generally results in declining PPDs, indicating reduced effort. However, the decline in PPD over SNRs has been observed to be less pronounced for hearing-impaired (HI) compared to normal-hearing (NH) listeners. The presence of a competing talker during speech recognition generally resulted in larger PPDs as compared to the presence of a fluctuating or stationary background noise. The aim of the present study was to examine the interplay between hearing-status, a broad range of SNRs corresponding to sentence recognition performance varying from 0 to 100% correct, and different masker types (stationary noise and single-talker masker) on the PPD during speech perception. Twenty-five HI and 32 age-matched NH participants listened to sentences across a broad range of SNRs, masked with speech from a single talker (−25 dB to +15 dB SNR) or with stationary noise (−12 dB to +16 dB). Correct sentence recognition scores and pupil responses were recorded during stimulus presentation. With a stationary masker, NH listeners show maximum PPD across a relatively narrow range of low SNRs, while HI listeners show relatively large PPD across a wide range of ecological SNRs. With the single-talker masker, maximum PPD was observed in the mid-range of SNRs around 50% correct sentence recognition performance, while smaller PPDs were observed at lower and higher SNRs. Mixed-model ANOVAs revealed significant interactions between hearing-status and SNR on the PPD for both masker types. Our data show a different pattern of PPDs across SNRs between groups, which indicates that listening and the allocation of effort during listening in daily life environments may be different for NH and HI listeners

Wightman function and Casimir densities on AdS bulk with application to the Randall-Sundrum braneworld

Positive frequency Wightman function and vacuum expectation value of the energy-momentum tensor are computed for a massive scalar field with general curvature coupling parameter subject to Robin boundary conditions on two parallel plates located on $D+1$ - dimensional AdS background. The general case of different Robin coefficients on separate plates is considered. The mode summation method is used with a combination of a variant of the generalized Abel-Plana formula for the series over zeros of combinations of cylinder functions. This allows us to extract manifestly the parts due to the AdS spacetime without boundaries and boundary induced parts. The asymptotic behavior of the vacuum densities near the plates and at large distances is investigated. The vacuum forces acting on the boundaries are presented as a sum of the self-action and interaction forces. The first one contains well-known surface divergences and needs further regularization. The interaction forces between the plates are attractive for Dirichlet scalar. We show that threre is a region in the space of parameters defining the boundary conditions in which the interaction forces are repulsive for small distances and attractive for large distances. An application to the Randall-Sundrum braneworld with arbitrary mass terms on the branes is discussed.Comment: 26 pages, 6 figures, discussions and figure labels added, accepted for publication in Nuclear Physics

Cognitive mediators of the effect of peer victimization on loneliness

The impact of stress on psychological adjustment may be mediated by cognitive interpretations (i.e., appraisals) of events for individuals. Defining characteristics of loneliness suggest that appraisals of blame, threat, and perceived control may be particularly important in this domain. AIMS: To evaluate the extent to which cognitive appraisals (perceived control, threat, and blame) can mediate the effect of peer victimization on loneliness. SAMPLE: One hundred and ten children (54 boys, 56 girls) aged 8-12 years attending mainstream schools in Scotland. METHOD: Self-report measures of peer victimization, appraisal, and loneliness. RESULTS: Perceived control partially mediated the effects of peer victimization on loneliness, but neither blame nor threat were mediators. All three measures of control were significantly associated with loneliness at the bivariate level, but only perceived control was significant when the appraisals were entered as predictors in a hierarchical multiple linear regression. CONCLUSIONS: The results highlight the importance of research designs assessing multiple categories of appraisal. Furthermore, they suggest that intervention efforts aiming to combat feelings of loneliness within a peer victimization context should address children's appraisals of perceived control

The Casimir Effect in the Presence of Compactified Universal Extra Dimensions

The Casimir force in a system consisting of two parallel conducting plates in the presence of compactified universal extra dimensions (UXD) is analyzed. The Casimir force with UXDs differs from the force obtained without extra dimensions. A new power law for the Casimir force is derived. By comparison to experimental data the size R of the universal extra dimensions can be restricted to R < 10 nm for one extra dimension.Comment: 4 pages, 1 figure, error in polarizations corrected, Casimir Effect in 4D-limit reproduce