11,190 research outputs found

    Planning for town centre revitalisation in a declining context : a thesis presented in partial fulfilment of the requirements for the degree of Master of Resource and Environmental Planning at Massey University, Palmerston North, New Zealand

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    "This research explored how the Ruapehu District views its declining population and economy, how town centre revitalisation has attempted to address decline in Ohakune, and the outcomes of this revitalisation, with the aim of developing guidelines for local authorities in declining contexts to consider when undertaking revitalisation to address decline. As the Ruapehu District Council is including town centre renewal as part of their aspirations for economic development and reversing decline, this research looks at the effects of revitalisation of town centres in a declining context by asking the question: What should local authorities in declining contexts consider when planning for town centres to enable people and communities to provide for their social, economic, cultural and environmental well-being?"--Research Aim & Question, p.

    Development of a chemical heater for a Mars rough-landing capsule

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    Chemical reaction heater for Mars rough-landing capsul

    Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells.

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    Glucagon is one of the main regulators of blood glucose levels and dysfunctional stimulus secretion coupling in pancreatic A-cells is believed to be an important factor during development of diabetes. However, regulation of glucagon secretion is poorly understood. Recently it has been shown that Na(+)/glucose co-transporter (SGLT) inhibitors used for the treatment of diabetes increase glucagon levels in man. Here, we show experimentally that the SGLT2 inhibitor dapagliflozin increases glucagon secretion at high glucose levels both in human and mouse islets, but has little effect at low glucose concentrations. Because glucagon secretion is regulated by electrical activity we developed a mathematical model of A-cell electrical activity based on published data from human A-cells. With operating SGLT2, simulated glucose application leads to cell depolarization and inactivation of the voltage-gated ion channels carrying the action potential, and hence to reduce action potential height. According to our model, inhibition of SGLT2 reduces glucose-induced depolarization via electrical mechanisms. We suggest that blocking SGLTs partly relieves glucose suppression of glucagon secretion by allowing full-scale action potentials to develop. Based on our simulations we propose that SGLT2 is a glucose sensor and actively contributes to regulation of glucagon levels in humans which has clinical implications

    A Decision Support Tool for Energy-Optimising Railway Timetables Based on Behavioural Data

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    Energy-efficient train operation can reduce operating costsand contribute to a reduction in CO2 emissions. To utilise the fullpotential of energy-efficient driving, energy-efficient timetabling is crucial.To address this problem, we propose a decision support tool togive timetable planners insight into energy consumption for a giventimetable. The decision support tool uses a recommendation based onquadratic optimisation of a given timetable. Differently to previous work,the optimisation uses actual data from the train operation, which is preprocessed by data reduction, outlier detection, and second-degree regression modelling. With this approach, our results show that the optimisedtimetables can save up to 33.07% energy on a single section and up to6.23% for a complete timetable. Solutions are computed in less than amicrosecond

    LF-PPL: A Low-Level First Order Probabilistic Programming Language for Non-Differentiable Models

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    We develop a new Low-level, First-order Probabilistic Programming Language (LF-PPL) suited for models containing a mix of continuous, discrete, and/or piecewise-continuous variables. The key success of this language and its compilation scheme is in its ability to automatically distinguish parameters the density function is discontinuous with respect to, while further providing runtime checks for boundary crossings. This enables the introduction of new inference engines that are able to exploit gradient information, while remaining efficient for models which are not everywhere differentiable. We demonstrate this ability by incorporating a discontinuous Hamiltonian Monte Carlo (DHMC) inference engine that is able to deliver automated and efficient inference for non-differentiable models. Our system is backed up by a mathematical formalism that ensures that any model expressed in this language has a density with measure zero discontinuities to maintain the validity of the inference engine.Comment: Published in the proceedings of the 22nd International Conference on Artificial Intelligence and Statistics (AISTATS

    Persuasive Technology for Learning in Business Context

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    "Persuasive Design is a relatively new concept which employs general principles of persuasion that can be implemented in persuasive technology. This concept has been introduced by BJ Fogg in 1998, who since then has further extended it to use computers for changing attitudes and behaviour. Such principles can be applied very well in learning and teaching: in traditional human-led learning, teachers always have employed persuasion as one of the elements of teaching. Persuasive technology moves these principles into the digital domain, by focusing on technology that inherently stimulates learners to learn more quickly and effectively. This is very relevant for the area of Business Management in several aspects: Consumer Behavior, Communications, Human Resource, Marketing & Advertising, Organisational Behavior & Leadership. The persuasive principles identified by BJ Fogg are: reduction, tunnelling, tailoring, suggestion, self-monitoring, surveillance, conditioning, simulation, social signals. Also relevant is the concept of KAIROS, which means the just-in-time, at the right place provision of information/stimulus. In the EuroPLOT project (2010-2013) we have developed persuasive learning objects and tools (PLOTs) in which we have applied persuasive designs and principles. In this context, we have developed a pedagogical framework for active engagement, based on persuasive design in which the principles of persuasive learning have been formalised in a 6-step guide for persuasive learning. These principles have been embedded in two tools – PLOTmaker and PLOTLearner – which have been developed for creating persuasive learning objects. The tools provide specific capability for implementing persuasive principles at the very beginning of the design of learning objects. The feasibility of employing persuasive learning concepts with these tools has been investigated in four different case studies with groups of teachers and learners from realms with distinctly different teaching and learning practices: Business Computing, language learning, museum learning, and chemical substance handling. These case studies have involved the following learner target groups: school children, university students, tertiary students, vocational learners and adult learners. With regards to the learning context, they address archive-based learning, industrial training, and academic teaching. Alltogether, these case studies include participants from Sweden, Africa (Madagascar), Denmark, Czech Republic, and UK. One of the outcomes of this investigation was that one cannot apply a common set of persuasive designs that would be valid for general use in all situations: on the contrary, the persuasive principles are very specific to learning contexts and therefore must be specifically tailored for each situation. Two of these case studies have a direct relevance to education in the realm of Business Management: Business Computing and language learning (for International Business). In this paper we will present the first results from the evaluation of persuasive technology driven learning in these two relevant areas.
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