Research study on instrument unit thermal conditioning heat sink concepts First quarterly progress report, 11 Mar. - 31 May 1966

Water boiler and water sublimator heat sink concepts, visualization test module, and sublimation mechanis

Entdecken symmetrischer Dreieckspyramiden

Die Beschäftigung mit räumlicher Geometrie ist ein wichtiger Aspekt des Mathematikunterrichts, der leider zu wenig Beachtung findet. Die Dreieckspyramiden (allgemeine Tetraeder) sind einfache Körper und können leicht als Kanten-, Flächen-, Vollmodell hergestellt werden. Formbetrachtungen über sie sollten in den Unterricht der Klassenstufe 5/6 Eingang finden. Nachdem im 6. Schuljahr die ebenen Symmetrien behandelt wurden, lassen sich Symmetriebetrachtungen zu Dreieckspyramiden gut anschließen

The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria

The mitochondrial division machinery regulates mitochondrial dynamics and consists of Fis1p, Mdv1p, and Dnm1p. Mitochondrial division relies on the recruitment of the dynamin-related protein Dnm1p to mitochondria. Dnm1p recruitment depends on the mitochondrial outer membrane protein Fis1p. Mdv1p interacts with Fis1p and Dnm1p, but is thought to act at a late step during fission because Mdv1p is dispensable for Dnm1p localization. We identify the WD40 repeat protein Caf4p as a Fis1p-associated protein that localizes to mitochondria in a Fis1p-dependent manner. Caf4p interacts with each component of the fission apparatus: with Fis1p and Mdv1p through its NH2-terminal half and with Dnm1p through its COOH-terminal WD40 domain. We demonstrate that mdv1{Delta} yeast contain residual mitochondrial fission due to the redundant activity of Caf4p. Moreover, recruitment of Dnm1p to mitochondria is disrupted in mdv1{Delta} caf4{Delta} yeast, demonstrating that Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites. Our studies support a revised model for assembly of the mitochondrial fission apparatus

The effects of +/- reasoning demands on L2 oral production during

Màster de Lingüística Aplicada i Adquisició de Llengües en Contextos Multilingües, Departament de Filologia Anglesa i Alemanya, Universitat de Barcelona, Any: 2009, Supervisor: Dr. Roger Gilabert GuerreroThe current study analyses data collected during a decision-making task in order to determine how task complexity, manipulated along the resource directing variable of +/- reasoning demands, affects dimensions of fluency, accuracy and linguistic complexity while the resource dispersing variable of less planning time remained constant. In addition to general measures, three developmentally based, task specific measures derived from results of studies of conjoined clauses and elaborated noun phrases, have been employed in order to determine specific effects of increased task complexity on structural complexity. Overall results indicate that as cognitive complexity increased, structural complexity was positively affected as the intended message was conceptualized in such a way as to effectively meet the demands of the increased reasoning demands. Lexical complexity, accuracy, and fluency were not affected although greater demands along the resource dispersing variable of less planning time may have minimized effects of increased reasoning demands along these dimensions. Task specific measures were successful in identifying instances of structural complexity where general measures were not able to do so

Analysis of a two-dimensional type 6 shock-interference pattern using a perfect-gas code and a real-gas code

Numerical codes were developed to calculate the two dimensional flow field which results when supersonic flow encounters double wedge configurations whose angles are such that a type 4 pattern occurs. The flow field model included the shock interaction phenomena for a delta wing orbiter. Two numerical codes were developed, one which used the perfect gas relations and a second which incorporated a Mollier table to define equilibrium air properties. The two codes were used to generate theoretical surface pressure and heat transfer distributions for velocities from 3,821 feet per second to an entry condition of 25,000 feet per second

Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets

The polyubiquitin receptor Rpn10 targets ubiquitylated Sic1 to the 26S proteasome for degradation. In contrast, turnover of at least one ubiquitin-proteasome system (UPS) substrate, CPY*, is impervious to deletion of RPN10. To distinguish whether RPN10 is involved in the turnover of only a small set of cell cycle regulators that includes Sic1 or plays a more general role in the UPS, we sought to develop a general method that would allow us to survey the spectrum of ubiquitylated proteins that selectively accumulate in rpn10 cells. Polyubiquitin conjugates from yeast cells that express hexahistidine-tagged ubiquitin (H6-ubiquitin) were first enriched on a polyubiquitin binding protein affinity resin. This material was then denatured and subjected to IMAC to retrieve H6-ubiquitin and proteins to which it may be covalently linked. Using this approach, we identified 127 proteins that are candidate substrates for the 26S proteasome. We then sequenced ubiquitin conjugates from cells lacking Rpn10 (rpn10) and identified 54 proteins that were uniquely recovered from rpn10 cells. These include two known targets of the UPS, the cell cycle regulator Sic1 and the transcriptional activator Gcn4. Our approach of comparing the ubiquitin conjugate proteome in wild-type and mutant cells has the resolving power to identify even an extremely inabundant transcriptional regulatory protein and should be generally applicable to mapping enzyme substrate networks in the UPS