Experimental results of superconducting magnet behaviour during discharging into the external load

The basic part of every SMES (Superconducting magnetic energy storage) system is a superconducting magnet. All eventsof electrical nature which happen during its charging,, bypassing and discharging are transient. The article deals with experimentalresults of the superconducting magnet behaviour, especially during the period of its discharging into the prepared external load

Detection of Elliott Waves Using Neural Networks

Bakalářská práce se zabývá využitím umělých neuronových sítí pro detekci Elliottových vln ve statické časové řadě. Použitá je konkrétně jednoduchá committee machine sestávající z vícevrtsvých perceptronů, trénovaných pomocí algoritmu pružného zpětného šíření chyby. Práce obsahuje návrh a implementaci apikace pro detekci impulzních vln na vstupních datech.This thesis deals with application of artificial neural networks for detection of Elliott waves in static time-series. It is focused mainly on use of simple committee machine consisting of multilayer perceptrons trained by resillient propagation algorithm. Thesis contains design and implementation of application for detection of impulsive waves on input signal.

Characteristics of orange-whey fermented beverages

The aim of the present work was to determine the populations of ABT culture microorganisms in orange and orangewhey drinks after fermentation and during 28-day storage. The evaluation involved fermented fruit drinks without whey or with added acid or sweet (rennet) whey. The Streptococcus thermophilus and Bifidobacteria counts were initially 3.5×105–8.3×105 CFU cm−3 and 2.4×106–5.9×106 CFU cm−3, respectively, and did not increase during fermentation. However, an increase was observed in the Lb. acidophilus count, which amounted to 3.0×106–2.4×107 CFU cm−3 after fermentation. During storage, the Str. thermophilus and Lb. acidophilus counts remained constant, but that for Bifidobacteria fell to 103 CFU cm−3 after 28 days. Bacteria survivability was higher in drinks containing whey than in non-whey orange drinks. In 100 cm3, antioxidant activity against ABTS/DPPH radicals varied between 260 and 550 μmol TE; vitamin C content was in the range of 15.7–17.6 mg; polyphenols were 26.6–34.4 mg (+)catechin. In the sensory evaluation the best results were obtained for non-whey drinks and those containing 50% acid whey

Working memory related brain network connectivity in individuals with schizophrenia and their siblings

A growing number of studies have reported altered functional connectivity in schizophrenia during putatively “task-free” states and during the performance of cognitive tasks. However, there have been few systematic examinations of functional connectivity in schizophrenia across rest and different task states to assess the degree to which altered functional connectivity reflects a stable characteristic or whether connectivity changes vary as a function of task demands. We assessed functional connectivity during rest and during three working memory loads of an N-back task (0-back, 1-back, 2-back) among: (1) individuals with schizophrenia (N = 19); (2) the siblings of individuals with schizophrenia (N = 28); (3) healthy controls (N = 10); and (4) the siblings of healthy controls (N = 17). We examined connectivity within and between four brain networks: (1) frontal–parietal (FP); (2) cingulo-opercular (CO); (3) cerebellar (CER); and (4) default mode (DMN). In terms of within-network connectivity, we found that connectivity within the DMN and FP increased significantly between resting state and 0-back, while connectivity within the CO and CER decreased significantly between resting state and 0-back. Additionally, we found that connectivity within both the DMN and FP was further modulated by memory load. In terms of between network connectivity, we found that the DMN became significantly more “anti-correlated” with the FP, CO, and CER networks during 0-back as compared to rest, and that connectivity between the FP and both CO and CER networks increased with memory load. Individuals with schizophrenia and their siblings showed consistent reductions in connectivity between both the FP and CO networks with the CER network, a finding that was similar in magnitude across rest and all levels of working memory load. These findings are consistent with the hypothesis that altered functional connectivity in schizophrenia reflects a stable characteristic that is present across cognitive states

Using MRI devices for the energy storage purposes

It is well known, that the electrical energy storage in the large scale is basically a difficult process. Such a process is connected with energy losses, as most frequently it is the conversion of electrical energy into another form, for example mechanical, and then back to the primal electrical form. Though, the SMES technology offers the energy storage in an unchanged form, which is advantageous primarily in the achieved efficiency. The magnetic resonance imaging (MRI) devices, commonly used in the medical facilities are based on the basis of superconducting magnet. After its rejection from operation, (basically caused only by its „software fustiness“ and not by functional faults), there is a possibility of using such devices for the energy storage purposes. Additionally, such a technology of storage is also ecological. A research project is running at the Faculty of Mining, Ecology, Process Control and Geotechnologies (F BERG), the Department of Business and Management, in the field of using rejected MRI for energy storage purposes

Quantitative Methods for Tracking Cognitive Change 3 Years After Coronary Artery Bypass Surgery

Background: The analysis and interpretation of change in cognitive function test scores after Coronary Artery Bypass Grafting (CABG). Longitudinal studies with multiple outcomes present considerable statistical challenges. Application of hierarchical linear statistical models can estimate the effects of a surgical intervention on the time course of multiple biomarkers. Methods: We use an analyze then summarize approach whereby we estimate the intervention effects separately for each cognitive test and then pool them, taking appropriate account of their statistical correlations. The model accounts for dropouts at follow-up, the chance of which may be related to past cognitive score, by implicitly imputing the missing data from individuals’ past scores and group patterns. We apply this approach to a study of the effects of CABG on the time course of cognitive function as measured by 16 separate neuropsychological test scores, clustered into 8 cognitive domains. The study includes measurements on 140 CABG patients and 92 nonsurgical controls at baseline, and 3, 12, and 36 months. Including a nonsurgical control group allows comparison of changes in cognition over time between the surgery group and patients with similar risk factors, controlling for potential effects of aging and vascular disease. Results: We find that CABG patients have very longitudinal changes from baseline in cognitive function similar to those observed for nonsurgical controls. Any small differences tend to favor greater improvement in CABG patients than in the nonsurgical controls. Conclusions: The methods used have application to a wide range of intervention studies in which multiple biomarkers are followed over time to quantify health effects. Software to implement the methods in commonly used statistical packages is available from the authors at http://www.biostat.jhsph.edu/research/software.shtml

Comparison of the miRNA profiles in HPV-positive and HPV-negative tonsillar tumors and a model system of human keratinocyte clones

Background Better insights into the molecular changes involved in virus-associated and -independent head and neck cancer may advance our knowledge of HNC carcinogenesis and identify critical disease biomarkers. Here we aimed to characterize the expression profiles in a matched set of well-characterized HPV-dependent and HPV-independent tonsillar tumors and equivalent immortalized keratinocyte clones to define potential and clinically relevant biomarkers of HNC of different etiology. Methods Fresh frozen tonsillar cancer tissues were analyzed together with non-malignant tonsillar tissues and compared with cervical tumors and normal cervical tissues. Furthermore, relative miRNAs abundance levels of primary and immortalized human keratinocyte clones were evaluated. The global quantitation of miRNA gene abundance was performed using a TaqMan Low Density Array system. The confirmation of differentially expressed miRNAs was performed on a set of formalin-fixed paraffin-embedded tumor samples enriched for the tumor cell fraction by macrodissection. Results We defined 46 upregulated and 31 downregulated miRNAs characteristic for the HPV-positive tonsillar tumors and 42 upregulated miRNAs and 42 downregulated miRNAs characteristic for HPV-independent tumors. In comparison with the expression profiles in cervical tumors, we defined miR-141-3p, miR-15b-5p, miR-200a-3p, miR-302c-3p, and miR-9-5p as specific for HPV induced malignancies. MiR-335-5p, miR-579-3p, and miR-126-5p were shared by the expression profiles of HPV-positive tonsillar tumors and of the HPV immortalized keratinocyte clones, whereas miR-328-3p, miR-34c-3p, and miR-885-5p were shared by the miRNA profiles of HPV-negative tonsillar tumors and the HPV-negative keratinocytes. Conclusions We identified the miRNAs characteristic for HPV-induced tumors and tonsillar tumors of different etiology, and the results were compared with those of the model system. Our report presents the basis for further investigations leading to the identification of clinically relevant diagnostic and/or therapeutic biomarkers for tumors of viral and non-viral etiology