Brownian Dynamics of a Sphere Between Parallel Walls

We describe direct imaging measurements of a colloidal sphere's diffusion between two parallel surfaces. The dynamics of this deceptively simple hydrodynamically coupled system have proved difficult to analyze. Comparison with approximate formulations of a confined sphere's hydrodynamic mobility reveals good agreement with both a leading-order superposition approximation as well as a more general all-images stokeslet analysis.Comment: 4 pages, 3 figures, REVTeX with PostScript figure

Configurational temperatures and interactions in charge-stabilized colloid

We demonstrate that the configurational temperature formalism can be derived from the classical hypervirial theorem, and introduce a hierarchy of hyperconfigurational temperature definitions, which are particularly well suited for experimental studies. We then use these analytical tools to probe the electrostatic interactions in monolayers of charge-stabilized colloidal spheres confined by parallel glass surfaces. The configurational and hyperconfigurational temperatures, together with a novel thermodynamic sum rule, provide previously lacking self-consistency tests for interaction measurements based on digital video microscopy, and thereby cast new light on controversial reports of confinement-induced like-charge attractions. We further introduce a new method for measuring the pair potential directly that uses consistency of the configurational and hyperconfigurational temperatures as a set of constraints for a model-free search.Comment: 15 pages, 12 figures, submitted to J. Chem. Phy

Current drainage to a high voltage probe in a dilute plasma

Electron drainage current from dilute plasma through holes in high voltage dielectric probe

Playing “Sherlock Holmes”: Enhancing students’ understanding of prejudice and stereotyping

A very simple, innovative classroom exercise designed to heighten students\u27 understanding of stereotyping and prejudice is described. Students\u27 evaluation of the exercise was very positive. Students reported greater awareness and understanding of their own and others’ stereotypes and prejudice and of the negative effects of prejudice, with females more than males reporting enhanced awareness of others’ stereotyping. Students also rated the exercise as very enjoyable. There was a trend among Non-White more than White students to report that the exercise helped show them how to reduce stereotypes and more Non-White than White students offered solutions for reducing prejudice that involved actively reaching out and interacting with others different from themselves. Additional suggestions for instructors are discussed

Anomalous interactions in confined charge-stabilized colloid

Charge-stabilized colloidal spheres dispersed in weak 1:1 electrolytes are supposed to repel each other. Consequently, experimental evidence for anomalous long-ranged like-charged attractions induced by geometric confinement inspired a burst of activity. This has largely subsided because of nagging doubts regarding the experiments' reliability and interpretation. We describe a new class of thermodynamically self-consistent colloidal interaction measurements that confirm the appearance of pairwise attractions among colloidal spheres confined by one or two bounding walls. In addition to supporting previous claims for this as-yet unexplained effect, these measurements also cast new light on its mechanism.Comment: 8 pages, 5 figures, RevTeX4. Conference proceedings for CODEF-04, Colloidal Dispersions in External Fields, March 29 - April 1, 200

Measured current drainage through holes in various dielectrics up to 2 kilovolts in a dilute plasma

The electron current drained from a plasma through approximately 0.05 cm diameter holes in eight possible space applicable dielectrics placed on a probe biased at voltages up to 2000 V dc have been determined both theoretically and experimentally. The dielectrics tested were Parylene C and N, Teflon FEP type C, Teflon TFE, Nomex, quartz 7940 Corning Glass, Mylar A, and Kapton H polymide film. A Laplace field was used to predict an upper limit for the drainage current. The measured current was less than the computed current for quartz, Teflon FEP, and the 0.0123 cm thick sample of Parylene N for all voltages tested. The drainage current through the other dielectrics became equal to or greater than the computed current at a voltage below 2000 V. The magnitudes of the currents were between 0.1 and 10 microamperes for most of the dielectrics

The Computational Complexity of the Game of Set and its Theoretical Applications

The game of SET is a popular card game in which the objective is to form Sets using cards from a special deck. In this paper we study single- and multi-round variations of this game from the computational complexity point of view and establish interesting connections with other classical computational problems. Specifically, we first show that a natural generalization of the problem of finding a single Set, parameterized by the size of the sought Set is W-hard; our reduction applies also to a natural parameterization of Perfect Multi-Dimensional Matching, a result which may be of independent interest. Second, we observe that a version of the game where one seeks to find the largest possible number of disjoint Sets from a given set of cards is a special case of 3-Set Packing; we establish that this restriction remains NP-complete. Similarly, the version where one seeks to find the smallest number of disjoint Sets that overlap all possible Sets is shown to be NP-complete, through a close connection to the Independent Edge Dominating Set problem. Finally, we study a 2-player version of the game, for which we show a close connection to Arc Kayles, as well as fixed-parameter tractability when parameterized by the number of rounds played

Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking

Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment. In the present study, we undertook two approaches to determine the significance of plasticity involving system xc−. First, we examined whether the cysteine prodrug N-acetylcysteine attenuates cocaine-primed reinstatement by targeting system xc−. Rats were trained to self-administer cocaine (1 mg/kg/200 μl, i.v.) under extended access conditions (6 h/day). After extinction training, cocaine (10 mg/kg, i.p.) primed reinstatement was assessed in rats pretreated with N-acetylcysteine (0–60 mg/kg, i.p.) in the presence or absence of the system xc− inhibitor (S)-4-carboxyphenylglycine (CPG; 0.5 μM; infused into the nucleus accumbens). N-acetylcysteine attenuated cocaine-primed reinstatement, and this effect was reversed by co-administration of CPG. Secondly, we examined whether reduced system xc− activity is necessary for cocaine-primed reinstatement. To do this, we administered N-acetylcysteine (0 or 90 mg/kg, i.p.) prior to 12 daily self-administration sessions (1 mg/kg/200 μl, i.v.; 6 h/day) since this procedure has previously been shown to prevent reduced activity of system xc−. On the reinstatement test day, we then acutely impaired system xc− in some of the rats by infusing CPG (0.5 μM) into the nucleus accumbens. Rats that had received N-acetylcysteine prior to daily self-administration sessions exhibited diminished cocaine-primed reinstatement; this effect was reversed by infusing the cystine–glutamate exchange inhibitor CPG into the nucleus accumbens. Collectively these data establish system xc− in the nucleus accumbens as a key mechanism contributing to cocaine-primed reinstatement