Inversion using a new low-dimensional representation of complex binary geological media based on a deep neural network

Efficient and high-fidelity prior sampling and inversion for complex geological media is still a largely unsolved challenge. Here, we use a deep neural network of the variational autoencoder type to construct a parametric low-dimensional base model parameterization of complex binary geological media. For inversion purposes, it has the attractive feature that random draws from an uncorrelated standard normal distribution yield model realizations with spatial characteristics that are in agreement with the training set. In comparison with the most commonly used parametric representations in probabilistic inversion, we find that our dimensionality reduction (DR) approach outperforms principle component analysis (PCA), optimization-PCA (OPCA) and discrete cosine transform (DCT) DR techniques for unconditional geostatistical simulation of a channelized prior model. For the considered examples, important compression ratios (200 - 500) are achieved. Given that the construction of our parameterization requires a training set of several tens of thousands of prior model realizations, our DR approach is more suited for probabilistic (or deterministic) inversion than for unconditional (or point-conditioned) geostatistical simulation. Probabilistic inversions of 2D steady-state and 3D transient hydraulic tomography data are used to demonstrate the DR-based inversion. For the 2D case study, the performance is superior compared to current state-of-the-art multiple-point statistics inversion by sequential geostatistical resampling (SGR). Inversion results for the 3D application are also encouraging

Corak Pemikiran Dan Gerakan Aktivis Perempuan (Melacak Pandangan Keagamaan Aisyiyah Periode 1917–1945)

This paper discusses the patterns of religious thought of the women activistsin the early period of Aisyiyah. The women activists are Siti Walidah, Siti Bariyah, SitiAisyah, Siti Badilah, Siti Munjiyah, Siti Badilah, Siti Hayyinah, dan Siti Umniyah.Through ahistorical approach, the author founds a link between colonialism that occurin Muslim countries and the revival of the spirit of women activists in mobilizing theMuslims society. The author also asserts that the thought of Aisyiyah leaders includingin the Islamic modernism that mean are Islamists a progresive religion, Islam is areligion of liberation, enlighten and advance. This understanding is very influential inthe development of Aisyiyah recently. The formers of Aisyiyah aware of the importanceof women\u27s participation and role in Islamic Da\u27wah join with men to accelerate therealization of a prosperous society.Key words: Thought, women activists, AisyiyahMakalah ini membahas tentang corak pemikiran keagamaan perempuan aktivisgerakan Aisyiyah pada periode awal. Mereka adalah Siti Walidah, Siti Bariyah, SitiAisyah, Siti Badilah, Siti Munjiyah, Siti Badilah, Siti Hayyinah, dan Siti Umniyah.Melalui pendekatan historis, penulis menemukan kaitan antara gelombang kolonialismeyang terjadi di negara-negara muslim dengan semangat kebangkitan kaum perempuandalam menggerakkan kaum muslim khususnya kaum perempuan. Penulis jugamenegaskan bahwa pemikiran para tokoh Aisyiyah termasuk paham modernisme Islamyaitu Islam sebagai agama yang berkemajuan, agama dengan ajaran yang membebaskan,mencerahkan dan memajukan. Pemahaman ini sangat berpengaruh dalamperkembangan dakwah ‘Aisyiyah ke depan. Para tokoh Aisyiyah menyadari akanpentingnya perempuan berpartisipasi dan berperan dalam Dakwah Islam bersamasamadengan laki-laki untuk mempercepat terwujudnya masyarakat sejahtera

Notching early repolarization pattern in inferior leads increases risk of ventricular tachyarrhythmias in patients with acute myocardial infarction: a meta-analysis.

The aim of this of this meta-analysis was to examine the potential association between certain early repolarization (ER) characteristics and ventricular tachyarrhythmias (VTAs) in patients with acute myocardial infarction (AMI). We searched PubMed, Embase and Web of Science databases for records published until December 2014. Of the 658 initially identified records, 7 studies with a total of 1,565 patients (299 with ER and 1,266 without ER) were finally analyzed. Overall, patients with ER displayed a higher risk of VTAs following AMI compared to patients without ER [odds ratio (OR): 3.75, 95% CI: 2.62-5.37, p \u3c 0.00001]. Subgroup analyses showed that the diagnosis of ER prior to AMI onset is a better predictor of VTAs (OR: 5.70, p \u3c 0.00001) compared to those diagnosed after AMI onset (OR: 2.60, p = 0.00001). Remarkably, a notching morphology was a significant predictor of VTAs compared to slurring morphology (OR: 3.85, p = 0.002). Finally, an inferior ER location (OR: 8.85, p \u3c 0.00001) was significantly associated with increased risk of VTAs in AMI patients. In conclusion, our meta-analysis suggests that ER pattern is associated with greater risk of VTAs in patients with AMI. A notched ER pattern located in inferior leads confers the highest risk for VTAs in AMI

Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses

CRISPR/Cas9 derived from the bacterial adaptive immunity pathway is a powerful tool for genome editing, but the safety profiles of in vivo delivered Cas9 (including host immune responses to the bacterial Cas9 protein) have not been comprehensively investigated in model organisms. Nonalcoholic steatohepatitis (NASH) is a prevalent human liver disease characterized by excessive fat accumulation in the liver. In this study, we used adenovirus (Ad) vector to deliver a Streptococcus pyogenes–derived Cas9 system (SpCas9) targeting Pten, a gene involved in NASH and a negative regulator of the PI3K-AKT pathway, in mouse liver. We found that the Ad vector mediated efficient Pten gene editing even in the presence of typical Ad vector-associated immunotoxicity in the liver. Four months after vector infusion, mice receiving the Pten gene-editing Ad vector showed massive hepatomegaly and features of NASH, consistent with the phenotypes following Cre-loxP-induced Pten deficiency in mouse liver. We also detected induction of humoral immunity against SpCas9 and the potential presence of an SpCas9-specific cellular immune response. Our findings provide a strategy to model human liver diseases in mice and highlight the importance considering Cas9-specific immune responses in future translational studies involving in vivo delivery of CRISPR/Cas9

Loop effects and non-decoupling property of SUSY QCD in gb→tH−g b\to tH^{-}

One-loop SUSY QCD radiative correction to $gb \to tH^{-}$ cross section is calculated in the Minimal Supersymmetric Standard Model. We found that SUSY QCD is non-decoupling if the gluino mass and the parameter $\mu$, $A_t$ or $A_b$ are at the same order and get large. The non-decoupling contribution can be enhanced by large $\tan\beta$ and therefore large corrections to the hadronic production rates at the Tevatron and LHC are expected in the large $\tan\beta$ limit. The fundamental reason for such non-decoupling behavior is found to be some couplings in the loops being proportional to SUSY mass parameters.Comment: 15 pages, 5 PS figures. A proof of non-decouplings of SUSY-QCD, Comments on corresponding QCD correction and references adde

Systematic review and meta-analysis of chronic kidney disease as predictor of atrial fibrillation recurrence following catheter ablation

Background: Recent observational studies have shown that patients with chronic kidney disease (CKD) have higher risk of atrial fibrillation (AF) recurrence and, therefore, the value of catheter ablation therapy in patients with CKD has been doubted. The purpose of this meta-analysis was to systematically analyze the effect of CKD on recurrence of AF following catheter ablation.Methods: PubMed and Cochrane clinical trials databases were searched until August 2012. Of the 1966 initially identified studies, 4 observational studies with 1379 patients were analyzed.Results: The meta-analysis of these studies showed that CKD was associated with higher AF recurrence rate following single catheter ablation (HR = 1.96, 95% CI 1.35–2.85, p = 0.0004) while there were significant differences between individual trials (p = 0.07 and I2 = 58%). Sensitivity analysis suggested that this outcome was stable. A subgroup analysis showed that CKD has higher recurrent risk in patients with 100% paroxysmal AF (HR = 2.45, 95% CI 1.28–4.70, p = 0.007) than in patients with non 100% paroxysmal AF (HR = 1.65, 95% CI 1.15–2.36, p = 0.006).Conclusions: CKD was associated with higher AF recurrence rate following single catheter ablation. In addition, patients with 100% paroxysmal AF have higher risk than patients with non 100% paroxysmal AF that merits special consideration when evaluating patients for catheter-based AF ablation. Given that the CKD prevalence is rapidly increasing, there is an imperative need for better risk stratification of catheter ablation candidates.

An Algorithmic Study of Fully Dynamic Independent Sets for Map Labeling

Map labeling is a classical problem in cartography and geographic information systems (GIS) that asks to place labels for area, line, and point features, with the goal to select and place the maximum number of independent, i.e., overlap-free, labels. A practically interesting case is point labeling with axis-parallel rectangular labels of common size. In a fully dynamic setting, at each time step, either a new label appears or an existing label disappears. Then, the challenge is to maintain a maximum cardinality subset of pairwise independent labels with sub-linear update time. Motivated by this, we study the maximal independent set (MIS) and maximum independent set (Max-IS) problems on fully dynamic (insertion/deletion model) sets of axis-parallel rectangles of two types - (i) uniform height and width and (ii) uniform height and arbitrary width; both settings can be modeled as rectangle intersection graphs. We present the first deterministic algorithm for maintaining a MIS (and thus a 4-approximate Max-IS) of a dynamic set of uniform rectangles with amortized sub-logarithmic update time. This breaks the natural barrier of ( ) update time (where is the maximum degree in the graph) for vertex updates presented by Assadi et al. (STOC 2018). We continue by investigating Max-IS and provide a series of deterministic dynamic approximation schemes. For uniform rectangles, we first give an algorithm that maintains a 4-approximate Max-IS with O(1) update time. In a subsequent algorithm, we establish the trade-off between approximation quality 2(1 + 1 k ) and update time O(k2 log n), for k 2 N. We conclude with an algorithm that maintains a 2-approximate Max-IS for dynamic sets of unit-height and arbitrary-width rectangles with O(! log n) update time, where ! is the maximum size of an independent set of rectangles stabbed by any horizontal line. We have implemented our algorithms and report the results of an experimental comparison exploring the trade-off between solution quality and update time for synthetic and real-world map labeling instances