The Role of Circulating Biomarkers in the Early Diagnosis of Ovarian Cancer

Ovarian cancer is the leading cause of gynecologic-related cancer death and epithelial ovarian cancer (EOC) is the most lethal sub-type. EOC is usually asymptomatic, and few screening tests are available. Diagnosis of ovarian cancer can be difficult because of the nonspecific symptoms. Despite the various diagnostic methods used, there is no reliable early diagnostic test and it needs to be developed. Specific biomarkers may have potential with the least possible invasive procedure. Biomarkers with a high sensitivity to ovarian cancer should be identified. Circulating biomarkers that are significant tools for non-invasive early diagnosis can be analyzed using circulating tumor cells, exosomes, and circulating nucleic acids. Protein, gene, metabolite, and miRNA-based biomarkers can be used for ovarian cancer diagnosis. As non-coding RNAs, MiRNAs may have an important role in ovarian cancer diagnosis due to their effects on mRNA expression levels. The most recent developments regarding the potential of circulating biomarkers to detect early ovarian cancer is presented in this chapter

Pregnancy as an opportunity to explore brain-immune connections in mental health.

Pregnancys effects on the brain, behavior, and hormones provide a unique opportunity to study how the immune system integrates these adaptations and influences mental health

A WINning Approach: Teaching Science Communication Skills through Small-Group Workshops

Objectives: Research almost always culminates in the communication of findings. Despite the necessity of grant and manuscript writing throughout academic careers, scientific trainees often receive little guided practice in written communication. To fill this gap, we designed, implemented, and evaluated a voluntary writing initiative for biomedical students at a research-intensive (R1) university in the midwestern United States called Writing Initiative in Neuroscience (WIN). Method: WIN consisted of didactic and workshop components. The didactic component included discussions with topic-specific experts on writing grants and manuscripts for the public and for non-academic scientific careers. The workshop component consisted of small group-based peer review of participant writing samples. Student self-enrollment consistently filled all available seats over three separate cohorts, including those formed during the COVID-19 pandemic. Student self-assessments were implemented to determine improvements quantitatively and qualitatively in writing and peer-review across 3 years of WIN programming. Results: Student self-assessment of writing skills before and after programming revealed improved scientific writing competency with medium or large effect sizes. Qualitative self-assessments indicated perceived improvements in writing competency and confidence. Collectively, students who participated in WIN improved their writing and communication skills and gained experience in providing and receiving feedback. Conclusions: Ultimately, peer-led writing initiatives, such as WIN, may enhance scholarly training and lay a foundation for future trainee writing success across scientific disciplines. Implications for Theory or Practice: These results support the utility of a student-centered writing workshop for biomedical students. Our study combined aspects of multiple existing resources, including peer feedback, interdisciplinary student backgrounds, and professional editing guidance. Together, these features formed a flexible and practical writing workshop, which can be used as a template for biomedical training programs

Lents: Alternatives for the Future

This document is the complement to the Issues Analysis. The Issues Analysis looked at the problems and issues which confront the Lents neighborhood. This document proposes actions that can be taken to address the issues identified in the previous analysis. Each section, e.g. Environment, Transportation, etc., has its own goals and subsequent objectives and actions. A goal is a broad statement of what is the desired outcome for the neighborhood. More specific objectives identify what needs to be done to improve things and to remedy the identified problems. The actions are means to achieve an objective. Specific potential implementers are then proposed for each action suggested. Interconnections between different sections exist for many problems and solutions. For example, the light rail alignment is a transportation issue but has ramifications in all aspects of life. Because of the inter-relatedness of the urban system, it was concluded that a unifying vision would be the best vehicle to present the means of addressing the neighborhood\u27s issues. Three distinct visions of potential futures for the neighborhood of Lents are presented below. The time scale for these visions is long, approximately 50 years. This allows for three distinctly different visions for Lents. The three visions are; Status Quo, Urban Villages and Regional Attractor. The visions act to encompass all the linkages and provide direction towards a unified future state of existence for the neighborhood. An urban system, like any system, needs to have connection and continuity between its various parts for it to function efficiently. The visions are a means of achieving this. In the Status Quo vision the neighborhood will continue to move through time without major adjustments to its existing state. The actions for change are congruent with the existing state of the neighborhood. Goals and objectives for this vision relate directly to current neighborhood concerns. The suggested actions work towards alleviating current problems and making the neighborhood a better place to live, work and do business. The land use structure and neighborhood function would be not be altered in any significant way. The Urban Village\u27s fundamental idea is to strive for neighborhood selfsufficiency. The neighborhood is separated into nodes or activity centers. A node or activity center is a relatively small area of diverse and intense activity. The nodes help to define residents\u27 sense of neighborhood. A node might have a public open space, such as a developed park, which would be surrounded by mixed-use development, commercial on the first floor and residential above. The nodes would be linked by pedestrian friendly greenways (streets improved with trees and flora) encouraging walking as the preferred mode of transportation. Density would be increased around the nodes to further encourage pedestrian travel and make businesses economically viable to customers using this mode of travel. Educational facilities would be linked closely to neighborhood needs, and cottage industries would be encouraged. In the Regional Attractor vision, the neighborhood would serve a specialized function to the whole metropolitan region. The focus would switch from mainly residential concerns to primaily employment generating concerns. Industry and business would be the critical elements in this neighborhood vision. Automobile or transit use would be the major modes of travel to ensure the neighborhood has regional accessibility. The neighborhood would serve as a single component within a regional system. This document will explore each of these visions in greater depth and present the means to making the vision a reality. While no single vision of Lents will seem preferable to everyone, the hope in presenting these three distinctly different potential futures for the neighborhood, is to reinforce an understanding of the tradeoffs that must be considered when developing a Lents plan. The intent is not to actually see the implementation of one of these visions, but rather to make the choices that must be made between one action and another more explicit. Our sincere hope is that any dialoque this document provokes will be one in which the interests of all Lents residents, present and future, are considered

Analysis of underground excavations in strain softening rock masses

Imperial Users onl

Change, Transformation And Quality 4.0 With Scientific Approaches

Avcı toplayıcılıktan tarım üretimine geçerek takası, ticareti öğrenen, parayı bu amaçla standart araç olarak kullanan insanoğlu, rasyonel düşünmesi sayesinde neredeyse son 250 yılda 4 sanayileşme hamlesi gerçekleştirmiştir. Birincisi İngiltere’ den JameHumankind who have gone from hunting, gathering to agriculTurkishal production, learn to trade , to swap and use money as a standard tool for this purpose have realized 4 industrialization bumps in the last 250 years thanks to their rational thinking.

The role of the placenta-brain axis in psychoneuroimmune programming

Gestational exposures have enduring impacts on brain and neuroimmune development and function. Perturbations of pregnancy leading to placental structure/function deficits, cell stress, immune activation, and endocrine changes (metabolic, growth factors, etc.) all increase neuropsychiatric risk in offspring. The existing literature links obstetric diseases with placental involvement to offspring neuroimmune outcomes and neurodevelopmental risk. Psychoneuroimmune outcomes in offspring brain include changes to microglia, cytokine/chemokine production, cell stress, and long-term immunoreactivity. These outcomes are altered by structural, anti-angiogenic/hypoxic, inflammatory, and metabolic diseases of the placenta. This fetal programming occurs via direct placental passage or production of factors which can act directly on fetal brain substrates, or indirectly via action of circulating factors on intermediates in the placenta. Placental neuroendocrine, vascular/angiogenic, immune, and extracellular vesicular mechanisms are detailed. These mechanisms interact within various placental and pregnancy conditions. An increased understanding of the placental origins of psychoneuroimmunology will yield dividends for human health. Identifying maternal and placental biomarkers for fetal neuroimmune health may also revolutionize early diagnosis and precision psychiatry, empowering patients to make the best healthcare decisions for their families. Targeting placental mechanisms may be a valuable approach for the prevention and mitigation of intergenerational, lifelong neuropathology

G.722 WIDEBAND SPEECH CODEC IMPLEMENTATION ON BF-533 DSP

The technological developments in digital communication systems increase the usable bandwidth of sound signals which results in increased intelligibility and naturalness of the signal. The emerging digital communication systems enable the use of wideband speech codec in a wide area of applications. Recognizing the need of high quality wide band speech codec, several standardization activities have been recently conducted. G.722 is one of the first wideband speech codec standards implemented in the telecommunication systems. In this thesis, after examining the G.722 wideband speech codec theoretically, a real time implementation of G.722 wideband speech codec has been developed on Blackfin BF533 DSP development kit from Analog Devices. Also, G.722 Codec is optimized by using assembler for BF533. As a result to the thesis, very good speech performance is obtained in real time implementation of G.722 and optimization increases the eciency of Blackfin BF533 DSP drastically

A Model Proposal And Implementation Concerning Occupational Health And Safety Within The Framework Of World Class Manufacturkishing

Her uygulama ve operasyonda en iyi olmayı ve içinde barındırdığı her stratejiyi mükemmel düzeyde gerçekleştirmeyi hedefleyen yaklaşım son yıllarda Dünya Klasmanında Üretim (WCM) olarak anılmaktadır. WCM'nin içinde barındırdığı uygulama ve stratejilerin siThe approach, which aims at becoming the best in every application and operation realizing every strategy that it has at a perfect level, has been referred to as World Class ManufacTurkishing (WCM). The synergic effect of WCM inherent in application and