A Rating-Based Integrated Recommendation Framework with Improved Collaborative Filtering Approaches

Collaborative filtering (CF) approach is successfully applied in the rating prediction of personal recommendation. But individual information source is leveraged in many of them, i.e., the information derived from single perspective is used in the user-item matrix for recommendation, such as user-based CF method mainly utilizing the information of user view, item-based CF method mainly exploiting the information of item view. In this paper, in order to take full advantage of multiple information sources embedded in user-item rating matrix, we proposed a rating-based integrated recommendation framework of CF approaches to improve the rating prediction accuracy. Firstly, as for the sparsity of the conventional item-based CF method, we improved it by fusing the inner similarity and outer similarity based on the local sparsity factor. Meanwhile, we also proposed the improved user-based CF method in line with the user-item-interest model (UIIM) by preliminary rating. Second, we put forward a background method called user-item-based improved CF (UIBCF-I), which utilizes the information source of both similar items and similar users, to smooth itembased and user-based CF methods. Lastly, we leveraged the three information sources and fused their corresponding ratings into an Integrated CF model (INTE-CF). Experiments demonstrate that the proposed rating-based INTE-CF indeed improves the prediction accuracy and has strong robustness and low sensitivity to sparsity of dataset by comparisons to other mainstream CF approaches

Ti3C2Tx on copper and nickel foams with improved electrochemical performance produced via solution processing for supercapacitor

Herein, we demonstrate the fabrication of Ti3C2Tx electrodes using solution processing. Two-dimensional (2D) nanometer Ti3C2Tx flakes are site-aggregated on copper and nickel foam papers with a reconstituted threedimensional (3D) structure consisting of overlapping and open-pore 2D flakes. When Ti3C2Tx was used as electrochemical capacitor electrodes in 1 M Na2SO4 solution, the capacitances were comparable to literature values. There is a quantitative linear relationship between the capacitance and foam thicknesses. Given the process scalability and the morphological control that is possible, these results provide a promising road map for convenient and economical supercapacitors

SPTBN1 overexpression ameliorates atherosclerosis by inhibiting oxidative stress and inflammation via regulating the TRIM37/TRAF2/NF-κB pathway

Abstract Background Endothelial cell apoptosis and oxidative stress are pivotal drivers of atherosclerosis (AS) progression. It was revealed that spectrin beta, non-erythrocytic 1 (SPTBN1) levels were remarkably decreased in the atherosclerotic plaque vessels of advanced lesions. This study aimed to elucidate the roles of SPTBN1 in endothelial dysfunction during AS progression. Methods SPTBN1 levels in the plasma samples of AS patients and aortic tissues of AS mouse model were tested. Human umbilical vein endothelial cells (HUVECs) were stimulated with oxidized low-density lipoprotein (ox-LDL) to mimic atherosclerotic conditions. After transfection of SPTBN1 overexpression plasmids, cell viability, apoptosis, oxidative stress marker including reactive oxygen species (ROS), malondialdehyde (MDA), and superoxide dismutase (SOD), and inflammatory molecules including vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were examined. Then, the interaction of SPTBN1 and methyltransferase-like 14 (METTL14) was examined using co-immunoprecipitation assay. The m6A methylation level of tripartite motif-containing 37 (TRIM37) was determined using methylated RNA immunoprecipitation-qPCR (MeRIP-qPCR). Additionally, the effects of SPTBN1 overexpression on atherosclerotic plaque formation were assessed in a high-fat diet-induced AS mouse model. Results SPTBN1 was downregulated in plasma samples of AS patients andaortic tissues of AS mouse model. SPTBN1 overexpression suppressed apoptosis, oxidative stress, and inflammation in ox-LDL-treated HUVECs. Mechanistically, SPTBN1 inhibited TRIM37 expression by promoting METTL14-mediated TRIM37 m6A methylation. TRIM37 overexpression abolished the protective effects of SPTBN1 on ox-LDL-treated HUVECs. TRIM37 promoted K63-linked ubiquitination of tumor necrosis factor receptor-associated factor 2 (TRAF2) and activated the NF-κB pathway in HUVECs. Furthermore, SPTBN1 overexpression alleviated atherosclerotic plaque formation, arterial lesions and inflammation in AS mice. Conclusion SPTBN1 overexpression suppressed apoptosis, oxidative stress, and inflammation in ox-LDL-treated HUVECs by regulating the TRIM37/TRAF2/NF-κB pathway, thereby inhibiting AS development in mice. Our findings advance understanding of the molecular basis of endothelial homeostasis and identify a potential therapeutic target for AS

Postoperative serum mir-28-5p level has predictive value for the prognosis after endovascular abdominal aortic aneurysm repair

Abstract Background We explored the clinical significance of miR-28-5p pre- and post-endovascular abdominal aortic aneurysm repair (EVAR) in abdominal aortic aneurysm (AAA) patients. Methods Subjects included AAA patients receiving EVAR and non-AAA people without statistical differences from AAA patient in comorbidities/Framingham risk score. Fasting elbow venous blood (4 mL) was collected in the morning of the day of EVAR surgery and in the morning of 3 months post-EVAR. Pre-/post-EVAR serum miR-28-5p expression, AAA maximum diameter alterations, CD3+/CD4+/CD8+/TC/TG pre-/post-EVAR, and the correlations between miR-28-5p and AAA maximum diameter were investigated. Prediction of miR-28-5p on post-EVAR mortality, prognosis, and independent factors of post-EVAR death were analyzed using receiver operating characteristic curve (ROC)/Kaplan-Meier curve/univariable and multivariable Cox regression. According to the cut-off value of ROC curve for postoperative miR-28-5p was the cut-off value, and the patients were classified into the miR-28-5p high- and low-expression groups. The survival or death of both groups were compared after 48-month follow-up. Results Serum miR-28-5p levels in AAA patients dropped post-EVAR. AAA patients showed notable differences in CD3+/CD4+/CD8+/TC/TG levels pre-/post-EVAR. The miR-28-5p low-expression group exhibited higher CD3+/CD4+ and lower CD8+/TC/TG levels. We observed a positive correlation between post-EVAR miR-28-5p and AAA maximum diameter and between the pre-/post-EVAR miR-28-5p fold change and the AAA maximum diameter change. Postoperative miR-28-5p demonstrated good predictive value for postoperative death. Hypertension, Framingham risk score, TC, TG, and miR-28-5p were independent influencing factors of post-EVAR death. Conclusion EVAR decreased serum miR-28-5p expression in AAA patients. Post-operative miR-28-5p level and pre-/post-operative fold change level are positively-correlated with AAA diameter