Optimization of input parameters to a CN neuron model to simulate its activity during and between epileptic absence seizures

Peer reviewe

Pemeriksaan Kekuatan Tanah Dengan Perkuatan Anyaman Kawat (Studi Kasus : Kawasan Tinoor)

Ilmu keteknikan, dalam hal ini geoteknik harus dapat memberi jawaban atas kebutuhan daya dukung tanah yang diinginkan sesuai dengan keperluan konstruksi. Oleh karena itu, berbagai macam metode mulai dikembangkan termasuk metode pemberian perkuatan tanah (soil reinforcement) yaitu dengan menggunakan material geosintetik. Dalam penelitian ini digunakan anyaman kawat dan serat jute sebagai perkuatan. Penelitian ini bertujuan untuk mengetahui kekuatan tanah yang diberi perkuatan anyaman kawat dan serat jute, berapa besar faktor keamanan dan melihat perbedaan faktor keamanan sebelum dan sesudah diberi perkuatan anyaman kawat dan serat jute sampai 5 lapis perkuatan dengan menggunakan program plaxis v.8.2 2D. Dari hasil peneliian, Faktor keamanan meningkat sesuai dengan pemberian jumlah lapis perkuatan yang diberikan terhadap tanah asli berturut- turut hingga 5 lapis perkuatan : 18.70 %, 36.51 %, 52.42 %, 92.75 %, 139.44 %

Nuclear safety policy working group recommendations on nuclear propulsion safety for the space exploration initiative

An interagency Nuclear Safety Working Group (NSPWG) was chartered to recommend nuclear safety policy, requirements, and guidelines for the Space Exploration Initiative (SEI) nuclear propulsion program. These recommendations, which are contained in this report, should facilitate the implementation of mission planning and conceptual design studies. The NSPWG has recommended a top-level policy to provide the guiding principles for the development and implementation of the SEI nuclear propulsion safety program. In addition, the NSPWG has reviewed safety issues for nuclear propulsion and recommended top-level safety requirements and guidelines to address these issues. These recommendations should be useful for the development of the program's top-level requirements for safety functions (referred to as Safety Functional Requirements). The safety requirements and guidelines address the following topics: reactor start-up, inadvertent criticality, radiological release and exposure, disposal, entry, safeguards, risk/reliability, operational safety, ground testing, and other considerations

Combining machine learning and simulations of a morphologically realistic model to study modulation of neuronal activity in cerebellar nuclei

Abstract from 23rd Annual Computational Neuroscience Meeting: CNS 2014 © 2014 Alva et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http:// creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.Epileptic absence seizures are characterized by synchronized oscillatory activity in the cerebral cortex that can be recorded as so-called spike-and-wave discharges (SWDs) by electroencephalogram. Although the cerebral cortex and the directly connected thalamus are paramount to this particular form of epilepsy, several other parts of the mammalian brain are likely to influence this oscillatory activity. We have recently shown that some of the cerebellar nuclei (CN) neurons, which form the main output of the cerebellum, show synchronized oscillatory activity during episodes of cortical SWDs in two independent mouse models of absence epilepsy [1]. The CN neurons that show this significant correlation with the SWDs are deemed to “participate” in the seizure activity and are therefore used in our current study designed to unravel the potential causes of such oscillatory firing patternsPeer reviewe

Analisa Kelelahan Struktur Pada Sambungan Antar Tiang Pancang Akibat Beban Horisontal

Indonesia merupakan salah satu Negara yang memiliki banyak sumber daya alam terutama minyak bumi, hal ini menyebabkan berkembangnya bangunan offshore di Indonesia. Jenis bangunan offshore yang digunakan di Indonesia yaitu jenis jacket platform. Tugas akhir ini bertujuan untuk mendesain jacket, dengan data topside load 1567 ton, tinggi gelombang 4,9987 m, periode gelombang 7 second. Mendesain jacket menggunakan software sap 2000 dimana desainnya berdasarkan peraturan API RP 2A WSD tahun 2002. Untuk analisis fatigue mengunakan tabel peristiwa gelombang (25 tahun). Dimensi tiang pancang yang digunakan sebesar 1,2 m dengan Daya dukung vertikal tiang pancang sebesar 210,835 ton dan Daya dukung horizontal sebesar 253,1879 ton. Dari analisis fatigue di sambungan antar tiang pancang didapat umur bangunan 95,202 tahun sehingga desain jacket aman untuk umur rencana bangunan 40 tahun

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy.

Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications. In advanced cancer, disease burden and cfDNA tumor content are often elevated, yielding unique precision oncology opportunities. We sought to demonstrate the utility of a pan-cancer, rapid, inexpensive, whole genome NGS of cfDNA approach (PRINCe) as a precision oncology screening strategy via ultra-low coverage (~0.01x) tumor content determination through genome-wide copy number alteration (CNA) profiling. We applied PRINCe to a retrospective cohort of 124 cfDNA samples from 100 patients with advanced cancers, including 76 men with metastatic castration-resistant prostate cancer (mCRPC), enabling cfDNA tumor content approximation and actionable focal CNA detection, while facilitating concordance analyses between cfDNA and tissue-based NGS profiles and assessment of cfDNA alteration associations with mCRPC treatment outcomes. Therapeutically relevant focal CNAs were present in 42 (34%) cfDNA samples, including 36 of 93 (39%) mCRPC patient samples harboring AR amplification. PRINCe identified pre-treatment cfDNA CNA profiles facilitating disease monitoring. Combining PRINCe with routine targeted NGS of cfDNA enabled mutation and CNA assessment with coverages tuned to cfDNA tumor content. In mCRPC, genome-wide PRINCe cfDNA and matched tissue CNA profiles showed high concordance (median Pearson correlation = 0.87), and PRINCe detectable AR amplifications predicted reduced time on therapy, independent of therapy type (Kaplan-Meier log-rank test, chi-square = 24.9, p < 0.0001). Our screening approach enables robust, broadly applicable cfDNA-based precision oncology for patients with advanced cancer through scalable identification of therapeutically relevant CNAs and pre-/post-treatment genomic profiles, enabling cfDNA- or tissue-based precision oncology workflow optimization

Relationship Among Self-Esteem, Blame And Guilt, And Sexuality Of Infertile Young Women

This descriptive correlational study purported to ascertain the relationships among self-esteem, blame and guilt, and sexuality of infertile young adult women, and to explore the basis for the study the Roy Adaptation Model (1976) was utilized. The convenience sample was comprised of 31 infertile women with diverse conditions who had undergone medical treatments for at least one year. The Infertility Questionnaire (IFQ) of Bernstein, Potts, and Mattox (1985) and researcher-developed questions were used in data collection to assess adaptation of the women to infertility. Quantitative data were analyzed using Pearson\u27s Product Moment Correlation while content analysis was used to describe the qualitative data. Data were collected at a private infertility clinic for three consecutive weeks. Results of the study supported the three correlational hypotheses. When infertile women experience blame and guilt, self-esteem and sexuality are decreased. Also, as self-esteem is lowered, sexuality is decreased. The main coping strategies used by these women were prayer, hobbies, anger, and crying. Perceived supportiveness of significant others and health care providers was found to decrease emotional distress. Implications for clinical practice and nursing education were suggested, and three recommendations for further research were offered