Synthesis of perbromates

Salts of heptavalent bromine were synthesized by a hot atom process, the beta decay of radioactive selenium-83 incorporated into a selenate. Formation of an unreactive perbromate ion led to preparation of macro amounts of perborate. A rubidium salt was isolated

Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C

Recurrent HCV infection following liver transplantation can lead to accelerated allograft injury that is difficult to treat with interferon. The aim of this study is to describe the first ever use of an interferon‐free, all oral regimen in a liver transplant recipient with severe recurrent HCV. A 54‐year‐old male with HCV genotype 1b developed severe cholestatic HCV at 6 months posttransplant with ascites, AST 503 IU/mL, alkaline phosphatase of 298 IU/mL, HCV RNA of 12 000 000 IU/mL, and histological cholestasis with pericellular fibrosis. Sofosbuvir, an HCV polymerase inhibitor (400 mg/day), and daclatasvir, an HCV NS5A replication complex inhibitor (60 mg/day), were co‐administered for 24 weeks. Within 4 weeks of initiating treatment, serum HCV RNA levels became undetectable and liver biochemistries normalized with concomitant resolution of ascites. The patient achieved a sustained virological response with undetectable HCV RNA at 9 months posttreatment. During and following treatment, the daily dose and blood level of tacrolimus remained stable and unchanged. The rapid and sustained suppression of HCV replication in this liver transplant recipient provides great promise for the use of combination oral antiviral regimens in other immunosuppressed and interferon refractory HCV patients. A patient with severe cholestatic hepatitis C virus genotype 1b infection at nine months after liver transplantation was successfully treated with a six‐month course of oral sofosbuvir in combination with daclatasvir and remains HCV RNA negative during posttreatment follow‐up with improved liver biochemistries and health.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98302/1/ajt12209.pd

A production trial with layers of four hybrids under different environmental conditions in the Eastern Province of Saudi Arabia.

161 Australorp X Rhode Island Red (RIR) X New Hampshire (NH) and 166 White Leghorn (WL) imported fowls were kept in insulated housing; 161 Australorp X RIR X NH, 166 WL, 154 RIR X WL and 148 RIR X NH X RIR fowls were kept in open houses. In the 6 groups resp., live weight at 126 days of age averaged 1602, 1227, 1578, 1234, 1397 and 1539 g, food consumption 4.02, 4.49, 4.03, 4.47, 4.25 and 4.17 kg/kg gain, overall laying percentage 56.6, 56.4, 52.5, 53.4, 55.0 and 37.5, egg production/hen 202, 201, 188, 191, 196 and 134, and egg weight 56.3, 56.3, 55.0, 55.8, 55.0 and 57.5 g. Egg mass averaged 1335, 1323, 1191, 1151, 1126 and 796 kg and food consumed/kg eggs produced 3.68, 3.53, 3.71, 3.25, 3.37 and 4.74 kg. Live weight at 16 mth of age averaged 2894, 2040, 2665, 1874, 2132 and 2517 g, and mortality 12.8, 11.1, 33.6, 43.5, 52.8 and 50.4%. (Abstract retrieved from CAB Abstracts by CABI’s permission

Feeding layers with different levels of energy and protein in the Eastern Province of Saudi Arabia.

Three hundred day-old Single Comb White Leghorn hybrid chicks were kept in insulated units with ventilators and 930 in traditional open-air units under a corrugated galvanised sheet roof in Saudi Arabia. All were fed on a standard diet. Growth in both groups was almost equal, but feed conversion was slightly more favourable in the insulated house. Overall mortality was considered to be favourable. The remaining 995 pullets, when of laying age, were divided into 8 groups, 2 of which were kept in the insulated units, and the rest in open-air units. During the laying period, 4 groups were fed on a high-energy (HC) mash and 4 on low-energy (LC) mash. A 17-h lighting schedule was maintained. Feed intake and energy and protein conversion were higher in the LC groups, while gross feed conversion was better in the HC group and the hens tended to be slightly heavier. There was no difference in egg production between feed groups, but that of hens in insulated units was higher than that of hens in open units. Mortality was higher in the HC group, the main cause being visceral lymphomatosis, and higher in the open housed groups, where 33 died from heat stroke in July, than in the insulated units. The authors conclude that the favourable aspects of the HC feeding were offset by the higher mortality and the higher feeding costs, and so the LC mash might be more profitable. I. F. la C. (Abstract retrieved from CAB Abstracts by CABI’s permission

Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis

Background Ultrasound (US) has largely replaced contrast venography as the definitive diagnostic test for deep vein thrombosis (DVT). We aimed to derive a definitive estimate of the diagnostic accuracy of US for clinically suspected DVT and identify study-level factors that might predict accuracy. Methods We undertook a systematic review, meta-analysis and meta-regression of diagnostic cohort studies that compared US to contrast venography in patients with suspected DVT. We searched Medline, EMBASE, CINAHL, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, Database of Reviews of Effectiveness, the ACP Journal Club, and citation lists (1966 to April 2004). Random effects meta-analysis was used to derive pooled estimates of sensitivity and specificity. Random effects meta-regression was used to identify study-level covariates that predicted diagnostic performance. Results We identified 100 cohorts comparing US to venography in patients with suspected DVT. Overall sensitivity for proximal DVT (95% confidence interval) was 94.2% (93.2 to 95.0), for distal DVT was 63.5% (59.8 to 67.0), and specificity was 93.8% (93.1 to 94.4). Duplex US had pooled sensitivity of 96.5% (95.1 to 97.6) for proximal DVT, 71.2% (64.6 to 77.2) for distal DVT and specificity of 94.0% (92.8 to 95.1). Triplex US had pooled sensitivity of 96.4% (94.4 to 97.1%) for proximal DVT, 75.2% (67.7 to 81.6) for distal DVT and specificity of 94.3% (92.5 to 95.8). Compression US alone had pooled sensitivity of 93.8 % (92.0 to 95.3%) for proximal DVT, 56.8% (49.0 to 66.4) for distal DVT and specificity of 97.8% (97.0 to 98.4). Sensitivity was higher in more recently published studies and in cohorts with higher prevalence of DVT and more proximal DVT, and was lower in cohorts that reported interpretation by a radiologist. Specificity was higher in cohorts that excluded patients with previous DVT. No studies were identified that compared repeat US to venography in all patients. Repeat US appears to have a positive yield of 1.3%, with 89% of these being confirmed by venography. Conclusion Combined colour-doppler US techniques have optimal sensitivity, while compression US has optimal specificity for DVT. However, all estimates are subject to substantial unexplained heterogeneity. The role of repeat scanning is very uncertain and based upon limited data

Een onderzoek naar een aantal veiligheidsrisico's met betrekking tot de schietsport in Nederland

In the past two years various organizations have conducted investigations into the tragic shooting incidient in Alphen aan de Rijn in the spring of 2011. In that incident, a 24-year old man with a license for three firearms took the lives of six people and his own. This study is based on the following problem statement: What potential safety risks can be distinguished in the shooting sports with regard to commercial interests, storage and transport of legal weapons and ammunition, and allowing shooting without a license?Naar aanleiding van het schietincident in Alphen aan den Rijn op 9 april 2011 heeft de Onderzoeksraad voor de Veiligheid een onderzoek ingesteld naar het Nederlandse systeem ter beheersing van het legaal wapenbezit en of het systeem voldoende functioneert. De minister van Veiligheid en Justitie heeft, mede namens de minister van Volksgezondheid, Welzijn en Sport (VWS), het rapport van de Onderzoeksraad op 29 september 2011 aan de Tweede Kamer aangeboden. In dit onderzoek staat de volgende probleemstelling centraal: 'Welke mogelijke veiligheidsrisico's zijn er binnen de schietsport te onderkennen aan 1) commerciële belangen, 2) opslag en vervoer van legale wapens en munitie en 3) het laten schieten zonder wapenverlof?' INHOUD: 1. Een onderzoek naar de schietsport in Nederland 2. Kenmerken en achtergronden van de schietsport in Nederland 3. Commerciële belangen 4. Opslag en vervoer van legale vuurwapens en munitie 5. Schieten zonder verlof 6. Conclusie 7. Samenvattin

A Study of the Correlation between Endoscopic and Histological Diagnoses in Gastroduodenitis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72433/1/j.1572-0241.1987.tb01777.x.pd

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases

We recently reported that differential gene expression and DNA methylation profiles in blood leukocytes of apparently healthy smokers predicts with remarkable efficiency diseases and conditions known to be causally associated with smoking, suggesting that blood-based omic profiling of human populations may be useful for linking environmental exposures to potential health effects. Here we report on the sex-specific effects of tobacco smoking on transcriptomic and epigenetic features derived from genome-wide profiling in white blood cells, identifying 26 expression probes and 92 CpG sites, almost all of which are affected only in female smokers. Strikingly, these features relate to numerous genes with a key role in the pathogenesis of cardiovascular disease, especially thrombin signaling, including the thrombin receptors on platelets F2R (coagulation factor II (thrombin) receptor; PAR1) and GP5 (glycoprotein 5), as well as HMOX1 (haem oxygenase 1) and BCL2L1 (BCL2-like 1) which are involved in protection against oxidative stress and apoptosis, respectively. These results are in concordance with epidemiological evidence of higher female susceptibility to tobacco-induced cardiovascular disease and underline the potential of blood-based omic profiling in hazard and risk assessment