Embolization in an adrenocortical carcinoma as palliative therapy

Background: With an annual incidence of 0.2% of new cases per 100,000 inhabitants, adrenocortical carcinoma is rare. In advanced tumor only palliative treatment modalities are practicable. Because of scarcity of the tumor, standard treatment has not been defined. The decision on therapy frequently depends on the individual situation. Tumor embolization and chemotherapy are amongst the possible options. Patient and Methods: We report on a case of a 32-year-old female patient with a large-volume hormonally active adrenocortical carcinoma and hematogenous liver metastases. This carcinoma was confirmed histologically by means of liver biopsy. Owing to the large tumor extent and metastatic spreading and also in view of the poor general condition of the patient, curative surgical therapy was not possible. For this reason, a local approach was chosen primarily with transarterial tumor embolization at the capillary level. Systemic chemotherapy was given afterwards. Results: Improvement of the patient's general condition, especially the pronounced pain symptoms, could be achieved for a short time by the embolization: both, the patient's clinical condition and the laboratory test parameters improved. However, a rapid tumor progression occured under chemotherapy, which was started after embolization. Conclusion: In advanced adrenocortical carcinoma, tumor embolization can lead to a stabilization of the disease and improvement of the symptoms as appraised by palliative criteria in some patients

Superconformal constraints for QCD conformal anomalies

Anomalous superconformal Ward identities and commutator algebra in N = 1 super-Yang-Mills theory give rise to constraints between the QCD special conformal anomalies of conformal composite operators. We evaluate the superconformal anomalies that appear in the product of renormalized conformal operators and the trace anomaly in the supersymmetric spinor current and check the constraints at one-loop order. In this way we prove the universality of QCD conformal anomalies, which define the non-diagonal part of the anomalous dimension matrix responsible for scaling violations of exclusive QCD amplitudes at the next-to-leading order.Comment: 30 pages, 2 figures, LaTe

Enter exitrons

Staiger D, Simpson GG. Enter exitrons. Genome Biology. 2015;16(1): 136.Exitrons are exon-like introns located within protein-coding exons. Removal or retention of exitrons through alternative splicing increases proteome complexity and thus adds to phenotypic diversity

An SU(3) model for octet baryon and meson fragmentation

The production of the octet of baryons and mesons in e^+ e^- collisions is analysed, based on considerations of SU(3) symmetry and a simple model for SU(3) symmetry breaking in fragmentation functions. All fragmentation functions, D_q^h(x, Q^2), describing the fragmentation of quarks into a member of the baryon octet (and similarly for fragmentation into members of the meson octet) are expressed in terms of three SU(3) symmetric functions, \alpha(x, Q^2), \beta(x, Q^2), and \gamma(x, Q^2). With the introduction of an SU(3) breaking parameter, \lambda, the model is successful in describing hadroproduction data at the Z pole. The fragmentation functions are then evolved using leading order evolution equations and good fits to currently available data at 34 GeV and at 161 GeV are obtained.Comment: 24 pages LaTeX file including 11 postscript figure file

GluK2-mediated excitability within the superficial layers of the entorhinal cortex

11 pages, 6 pages.-- PMID: 19440371 [PubMed].-- PMCID: PMC2679203.-- Supporting information available: Figure S1, doi:10.1371/journal.pone.0005576.s001 (0.63 MB TIF).Recent analysis of genetically modified mice deficient in different kainate receptor (KAR) subunits have strongly pointed to a role of the GluK2 subunit, mediating the vulnerability of the brain towards seizures. Research concerning this issue has focused mainly on the hippocampus. However, several studies point to a potential role of other parts of the hippocampal formation, in particular the entorhinal cortex, in the development of epileptic seizures. There is extensive cell death after such seizures in layer III of the medial entorhinal cortex (LIII mEC), making this region of special interest for investigation into related pathological conditions. We therefore characterized KAR mediated currents in LIII mEC pyramidal neurons by several different approaches. Using patch-clamp technique, in combination with glutamate uncaging in horizontal brain slices, we show that LIII mEC neurons exhibit KAR currents. Use of genetically modified mice reveal that these currents are mediated by GluK2 containing KARs. The IV curve indicates the predominant presence of a Ca2+ impermeable and edited form of the KAR. Finally, we show that GluK2 containing kainate receptors are essential for kainate-induced gamma oscillations within the entorhinal cortex.This study has been funded by the SFB 665 grant and P.B. is a member of and funded by the GRK 1123.Peer reviewe

Large-Area Scintillator Hodoscope with 50 ps Timing Resolution Onboard BESS

We describe the design and performance of a large-area scintillator hodoscope onboard the BESS rigidity spectrometer; an instrument with an acceptance of 0.3 m^{2}sr. The hodoscope is configured such that 10 and 12 counters are respectively situated in upper and lower layers. Each counter is viewed from its ends by 2.5 inch fine-mesh photomultiplier tubes placed in a stray magnetic field of 0.2 Tesla. Various beam-test data are presented. Use of cosmic-ray muons at ground-level confirmed 50 ps timing resolution for each layer, giving an overall time-of-flight resolution of 70 ps rms using a pure Gaussian resolution function. Comparison with previous measurements on a similar scintillator hodoscope indicates good agreement with the scaling law that timing resolution is proportional to 1/$\sqrt{N_{\rm pe}}$, where $N_{\rm pe}$ is the effective number of photoelectrons.Comment: 16 pages, 14 figure

MTSS1 is a critical epigenetically regulated tumor suppressor in CML

Chronic myeloid leukemia (CML) is driven by malignant stem cells that can persist despite therapy. We have identified Metastasis suppressor 1 (Mtss1/MIM) to be downregulated in hematopoietic stem and progenitor cells from leukemic transgenic SCLtTA/Bcr-Abl mice and in patients with CML at diagnosis, and Mtss1 was restored when patients achieved complete remission. Forced expression of Mtss1 decreased clonogenic capacity and motility of murine myeloid progenitor cells and reduced tumor growth. Viral transduction of Mtss1 into lineage depleted SCLtTA/Bcr-Abl bone marrow cells decreased leukemic cell burden in recipients, and leukemogenesis was reduced upon injection of Mtss1 overexpressing murine myeloid 32D cells. Tyrosine kinase inhibitor (TKI) therapy and reversion of Bcr-Abl expression increased Mtss1 expression but failed to restore it to control levels. CML patient samples revealed higher DNA methylation of specific Mtss1 promoter CpG sites that contain binding sites for Kaiso and Rest transcription factors. In summary, we identified a novel tumor suppressor in CML stem cells that is downregulated by both Bcr-Abl kinase-dependent and -independent mechanisms. Restored Mtss1 expression markedly inhibits primitive leukemic cell biology in vivo, providing a therapeutic rationale for the Bcr-Abl-Mtss1 axis to target TKI resistant CML stem cells in patients

Pion and Kaon Production in e+e−e^+e^- and epep Collisions at Next-to-Leading Order

We present new sets of fragmentation functions for charged pions and kaons, both at leading and next-to-leading order. They are fitted to data on inclusive charged-hadron production in $e^+e^-$ annihilation taken by TPC at PEP ($\sqrt s=29$~GeV) and to similar data by ALEPH at LEP, who discriminated between events with charm, bottom, and light- flavour fragmentation in their charged-hadron sample. We treat all partons independently and to properly incorporate the charm and bottom thresholds. Due to the sizeable energy gap between PEP and LEP, we are sensitive to the scaling violation in the fragmentation process, which allows us to extract a value for the asymptotic scale parameter of QCD, $\Lambda$. Recent data on inclusive charged-hadron production in tagged three-jet events by OPAL and similar data for longitudinal electron polarization by ALEPH allow us to pin down the gluon fragmentation functions. Our new fragmentation functions lead to an excellent description of a multitude of other $e^+e^-$ data on inclusive charged-hadron production, ranging from $\sqrt s=5.2$~GeV to LEP energy. In addition, they agree nicely with the transverse-momentum spectra of single charged hadrons measured by H1 and ZEUS in photoproduction at the $ep$ collider HERA, which represents a nontrivial check of the factorization theorem of the QCD-improved parton model.Comment: 22 pages, latex, 13 compressed ps figures in separate fil

Определение состояния атмосферного воздуха в зоне воздействия Сорского горно-обогатительного комбината на основе оценки показателей состояния снежного покрова (Республика Хакасия)

SummaryAlthough prothrombin complex concentrate (PCC) is increasingly used for the treatment of trauma-induced coagulopathy, few studies have investigated the impact and safety of PCC for this indication. The present study was performed to assess PCC for treatment of coagulopathy after blunt liver injury under severe hypothermia. Coagulopathy in 14 anaesthetised pigs was induced by haemodilution. Subsequently, standardised blunt liver injury was induced under severe hypothermia (32.8–33.2°C). Animals were randomised to receive either PCC (35 IU kg-1) or saline (control). Coagulation was assessed over the following 2 hours by thromboelastometry and thrombin generation. Internal organs were examined to determine presence of emboli. The administration of PCC showed a significant reduction in blood loss (p=0.002 vs. controls) and a significant increase in the rate of survival (p=0.022 vs. controls). Plasma thrombin generation in the PCC group increased considerably above baseline levels, with significant increases in peak thrombin levels and endogenous thrombin potential versus controls throughout the follow-up period. In addition, PT decreased significantly in the PCC group versus the control group. However, only slight improvements in thromboelastometry variables were observed. Histology showed an equal degree of liver injury in both groups, and no thromboembolism. In severely hypothermic pigs, the application of PCC corrected trauma-induced coagulopathy and reduced blood loss. Thus, the infusion of PCC might be a reasonable approach to reduce the need for blood cell transfusion in trauma. Furthermore, the impact and safety of PCC application can be monitored through thrombin generation and thromboelastometry under hypothermia.Note: This study was performed at the RWTH Aachen University Hospital, Pauwelsstrasse 30, D-52074 Aachen, Germany.</jats:p