In-flight friction and wear mechanism

A unique mechanism developed for conducting friction and wear experiments in orbit is described. The device is capable of testing twelve material samples simultaneously. Parameters considered critical include: power, weight, volume, mounting, cleanliness, and thermal designs. The device performed flawlessly in orbit over an eighteen month period and demonstrated the usefulness of this design for future unmanned spacecraft or shuttle applications

DETECTING EVIDENCE OF NON-COMPLIANCE IN SELF-REPORTED POLLUTION EMISSIONS DATA: AN APPLICATION OF BENFORD'S LAW

The paper introduces Digital Frequency Analysis (DFA) based on Benford's Law as a new technique for detecting non-compliance in self-reported pollution emissions data. Public accounting firms are currently adopting DFA to detect fraud in financial data. We argue that DFA can be employed by environmental regulators to detect fraud in self-reported pollution emissions data. The theory of Benford's Law is reviewed, and statistical justifications for its potentially widespread applicability are presented. Several common DFA tests are described and applied to North Carolina air pollution emissions data in an empirical example.Benford, digital frequency analysis, pollution monitoring, pollution regulation, enforcement, Environmental Economics and Policy, Q25, Q28,

Complex permeability of soft magnetic ferrite polyester resin composites at frequencies above 1 MHz

Composite soft magnetic materials consist of magnetic particles in a non-magnetic matrix. The properties of such materials can be modelled using effective medium theory. Measurements have been made of the complex permeability of composites produced using ferrite powder and polyester resin. The success of various effective medium expressions in predicting the variation of complex permeability with composition has been assessed

The translational potential of human induced pluripotent stem cells for clinical neurology: The translational potential of hiPSCs in neurology

The induced pluripotent state represents a decade-old Nobel prize-winning discovery. Human-induced pluripotent stem cells (hiPSCs) are generated by the nuclear reprogramming of any somatic cell using a variety of established but evolving methods. This approach offers medical science unparalleled experimental opportunity to model an individual patient's disease "in a dish." HiPSCs permit developmentally rationalized directed differentiation into any cell type, which express donor cell mutation(s) at pathophysiological levels and thus hold considerable potential for disease modeling, drug discovery, and potentially cell-based therapies. This review will focus on the translational potential of hiPSCs in clinical neurology and the importance of integrating this approach with complementary model systems to increase the translational yield of preclinical testing for the benefit of patients. This strategy is particularly important given the expected increase in prevalence of neurodegenerative disease, which poses a major burden to global health over the coming decades

Classification of pain and its treatment at an intensive care rehabilitation clinic

Introduction Treatment in an Intensive Care Unit (ICU) often necessitates uncomfortable and painful procedures for patients throughout their admission. There is growing evidence to suggest that chronic pain is becoming increasingly recognised as a long term problem for patients following an ICU admission [1]. Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) is a five week rehabilitation programme for patients and their caregivers after ICU discharge at Glasgow Royal Infirmary. This study investigated the incidence and location of chronic pain in patients discharged from ICU and classified the analgesics prescribed according to the World Health Organization analgesic Methods The InS:PIRE programme involved individual sessions for patients and their caregivers with a physiotherapist and a pharmacist along with interventions from medical, nursing, psychology and community services. The physiotherapist documented the incidence and pain location during the assessment. The pharmacist recorded all analgesic medications prescribed prior to admission and at their clinic visit. The patient’s analgesic medication was classified according to the WHO pain ladder from zero to three, zero being no pain medication and three being treatment with a strong opioid. Data collected was part of an evaluation of a quality improvement initiative, therefore ethics approval was waived. Results Data was collected from 47 of the 48 patients who attended the rehabilitation clinic (median age was 52 (IQR, 44-57) median ICU LOS was 15 (IQR 9-25), median APACHE II was 23 (IQR 18-27) and 32 of the patients were men (67 %)). Prior to admission to ICU 43 % of patients were taking analgesics and this increased to 81 % at the time of their clinic visit. The number of patients at step two and above on the WHO pain ladder also increased from 34 % to 56 %. Conclusions Of the patients seen at the InS:PIRE clinic two-thirds stated that they had new pain since their ICU admission. Despite the increase in the number and strength of analgesics prescribed, almost a quarter of patients still complained of pain at their clinic visit. These results confirm that pain continues to be a significant problem in this patient group. Raising awareness in primary care of the incidence of chronic pain and improving its management is essential to the recovery process following an ICU admission

Physical outcome measure for critical care patients following intensive care discharge

Introduction: The aim of this study was to evaluate the most suitable physical outcome measures to be used with critical care patients following discharge. ICU survivors experience physical problems such as reduced exercise capacity and intensive care acquired weakness. NICE guideline ‘Rehabilitation after critical illness’ (1) recommends the use of outcome measures however does not provide any specific guidance. A recent Cochrane review noted wide variability in measures used following ICU discharge (2). Methods: Discharged ICU patients attended a five week multidisciplinary programme. Patients’ physical function was assessed during the programme, at 6 months and 12 months post discharge. Three outcome measures were included in the initial two cohorts. The Six Minute Walk Test (6MWT) and the Incremental Shuttle Walk test (ISWT) were chosen as they have been used within the critical care follow up setting (2). The Chester Step Test (CST) is widely thought to be a good indicator of ability to return to work (one of the programmes primary aims). Ethics approval was waived as the programme was part of a quality improvement initiative. Results: Data was collected for the initial patients attending the programme (n = 13), median age was 52 (IQR = 38-72), median ICU LOS was 19 days (IQR = 4-91), median APACHE II was 23 (IQR = 19-41) and 11 were men. One patient was so physically debilitated that the CST or ISWT could not be completed however a score was achieved using the 6MWT. Another patient almost failed to achieve level 1 of the ISWT. Subsequent patients for this project (total n = 47) have all therefore been tested using the 6MWT. Good inter-rater and intrarater reliability and validity have been reported for the 6MWT (3). Conclusions: Exercise capacity measurement is not achievable for some patients with either the ISWT or the CST due to the severity of their physical debilitation. Anxiety, post-traumatic stress disorder and depression are common psychological problems post discharge (4), therefore using a test with a bleep is not appropriate. Therefore, the 6MWT is the most appropriate physical outcome measure to be used with critical care patients post discharge

Pharmacy intervention at an intensive care rehabilitation clinic

Introduction: During an intensive care stay, patients often have their chronic medications withheld for a variety of reasons and new drugs commenced [1]. As patients are often under the care of a number of different medical teams during their admission there is potential for these changes to be inadvertently continued [2]. Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) is a five week rehabilitation programme for patients and their caregivers after ICU (Intensive Care Unit) discharge at Glasgow Royal Infirmary. Within this programme a medication review by the critical care pharmacist provided an opportunity to identify and resolve any pharmaceutical care issues and also an opportunity to educate patients and their caregivers about changes to their medication. Methods: During the medication review we identified ongoing pharmaceutical care issues which were communicated to the patient’s primary care physician (GP) by letter or a telephone call. The patients were also encouraged to discuss any issues raised with their GP. The significance of the interventions was classified from those not likely to be of clinical benefit to the patient, to those which prevented serious therapeutic failure. Results: Data was collected from 47 of the 48 patients who attended the clinic (median age was 52 (IQR, 44-57) median ICU LOS was 15 (IQR 9-25), median APACHE II was 23 (IQR 18-27) and 32 of the patients were men (67%). The pharmacist made 69 recommendations; including 20 relating to drugs which had been withheld and not restarted, dose adjustments were suggested on 13 occasions and new drug recommendations were made for 10 patients. Duration of treatment for new medications started during hospital admission was clarified on 12 occasions. Lastly adverse drug effects were reported on 4 occasions and the incorrect drug was prescribed on 2 occasions. Of the interventions made 58% were considered to be of moderate to high impact. Conclusions: The pharmacist identified pharmaceutical care issues with 18.6% of the prescribed medications. Just over half of the patients reported that they were not made aware of any alterations to their prescribed medication on discharge. Therefore a pharmacy intervention is an essential part of an intensive care rehabilitation programme to address any medication related problems, provide education and to ensure patients gain optimal benefit from their medication

A study to explore the experiences of patient and family volunteers in a critical care environment: a phenomenological analysis

Introduction: ICU survivors suffer persistent physical, psychological and social problems in the months and years after discharge from critical care (1). Caregivers of these patients also suffer similar problems (2). As a result, an innovative, peer supported rehabilitation programme- Intensive Care Syndrome: Promoting Independence and Return to Employment (InS:PIRE) was created in Glasgow Royal Infirmary. This 5 week multi disciplinary programme, which is co facilitated by patient and family volunteers further along the recovery trajectory, aims to empower patients and caregivers to take control of their health and wellbeing. The objective of this study was to explore the experiences of the volunteers who participated in InS:PIRE. It also sought to identify the support required by volunteers from healthcare professionals involved in the project. Methods: Six in depth semi structured interviews were undertaken with volunteers (both patients and family members) involved in the InS:PIRE clinic by an assistant psychologist. A predetermined topic guide was utilised to guide interviews. Interviews were audio recorded and transcribed verbatim. Interpretative Phenomenological Analysis was used to analyse the transcripts (3). Peer Review was undertaken to ensure credibility of the findings. Results: Findings: Six key themes were identified from these interviews: the social impact of volunteering, shared experiences; supporting others; personal boundaries; support needs and personal gain. The importance of peer support and having a shared understanding of participants needs were key themes for the volunteers. Volunteers described the need for further support in areas such as: confidentiality; listening skills and understanding boundaries. Conclusions: The use of peer volunteers in this ICU rehabilitation service has been successful within this local context. Further, larger scale research studies, which explore further the impact of volunteering for ICU survivors are required

Real Lives: findings from the All-Ireland Gay Men’s Sex Surveys, 2003 and 2004

Duration: March 2000 - September 2010 Sigma Research has been working with Ireland's Gay Health Network (GHN) since 2000. GHN is an umbrella organisation working towards gay men's health and HIV prevention. GHN instigated a community-based, self-completion survey to take place across The Republic of Ireland and Northern Ireland during the summer of 2000 and commissioned Sigma Research to work with them. This large-scale community research project was the third such survey among gay men in Ireland, and built on previous findings. After the development and piloting of the survey, recruitment commenced at Dublin Pride in June 2000 and continued throughout the summer at similar events in Belfast, Derry, Galway, Limerick and Waterford. Recruitment in bars and clubs took place in Dublin and Cork, and social groups in more rural area were sent copies of the questionnaire and a request to distribute them to their members. 1,290 questionnaires were returned by gay men (81%), bisexual men (11%) and other homosexually active men living in Ireland. 19% of all respondents lived in Northern Ireland. A full survey report, including implications for HIV prevention planning is available to download. Since 2003 Gay Health Network members - particularly The Gay Men's Health Service (Health Services Executive) and the Rainbow Project, Northern Ireland - have collaborated with our online UK version of the Gay Men’s Sex Survey (Vital Statistics) by promoting it to men in Ireland via community websites and postcards distributed on the gay scene