MRI and clinical resolution of a suspected intracranial toxoplasma granuloma with medical treatment in a domestic short hair cat

A two-year-old cat was presented with a left paradoxical vestibular syndrome. MRI of the brain revealed an extra-axial homogenously contrast enhancing mass in the region of the left caudal cerebellar peduncle. Toxoplasma serology was consistent with active infection and the lesion was suspected to be a toxoplasma granuloma. Following eight weeks of tapering oral prednisolone and 11 weeks of oral clindamycin treatment, repeat MRI revealed resolution of the lesion. Eighteen months after initial diagnosis, the cat remained neurologically normal. Differential diagnoses for a solitary, extra-axial, contrast enhancing mass lesion in the feline brain should include toxoplasma granuloma, which can undergo MRI and clinical resolution with medical treatment

CP-violating Supersymmetric Higgs at the Tevatron and LHC

We analyze the prospect for observing the intermediate neutral Higgs boson ($h_2$) in its decay to two lighter Higgs bosons ($h_1$) at the presently operating hadron colliders in the framework of the CP violating MSSM using the PYTHIA event generator. We consider the lepton+ 4-jets+ \met channel from associate $W h_2$ production, with W h_2 \ra W h_1 h_1 \ra \ell \nu_\ell b \bar b b\bar b. We require two, three or four tagged $b$-jets. We explicitly consider all relevant Standard Model backgrounds, treating $c$-jets separately from light flavor and gluon jets and allowing for mistagging. We find that it is very hard to observe this signature at the Tevatron, even with 20 fb$^{-1}$ of data, in the LEP--allowed region of parameter space due to the small signal efficiency, even though the background is manageable. At the LHC, a priori huge SM backgrounds can be suppressed by applying judiciously chosen kinematical selections. After all cuts, we are left with a signal cross section of around 0.5 fb, and a signal to background ratio between 1.2 and 2.9. According to our analysis this Higgs signal should be viable at the LHC in the vicinity of present LEP exclusion once 20 to 50 fb$^{-1}$ of data have been accumulated at $\sqrt{s}=14$ TeV.Comment: 27 pages, 12 figure

Direct and Indirect Detection of Neutralino Dark Matter and Collider Signatures in an SO(10)SO(10) Model with Two Intermediate Scales

We investigate the detectability of neutralino Dark Matter via direct and indirect searches as well as collider signatures of an $SO(10)$ model with two intermediate scales. We compare the direct Dark Matter detection cross section and the muon flux due to neutralino annihilation in the Sun that we obtain in this model with mSUGRA predictions and with the sensitivity of current and future experiments. In both cases, we find that the detectability improves as the model deviates more from mSUGRA. In order to study collider signatures, we choose two benchmark points that represent the main phenomenological features of the model: a lower value of $|\mu|$ and reduced third generation sfermion masses due to extra Yukawa coupling contributions in the Renormalization Group Equations, and increased first and second generation slepton masses due to new gaugino loop contributions. We show that measurements at the LHC can distinguish this model from mSUGRA in both cases, by counting events containing leptonically decaying $Z^0$ bosons, heavy neutral Higgs bosons, or like--sign lepton pairs.Comment: 21 pages, 16 figure

Weighing the universe with accelerators and detectors

Suppose the lightest superpartner (LSP) is observed at colliders, and WIMPs are detected in explicit experiments. We point out that one cannot immediately conclude that cold dark matter (CDM) of the universe has been observed, and we determine what measurements are necessary before such a conclusion is meaningful. We discuss the analogous situation for neutrinos and axions; in the axion case we have not found a way to conclude axions are the CDM even if axions are detected.Comment: 15 pages, 3 figures; minor changes included and typos fixe

SUSY darkmatter at the LHC - 7 TeV

We have analysed the early LHC signatures of the minimal supergravity (mSUGRA) model. Our emphasis is on the 7 - $TeV$ run corresponding to an integrated luminosity of $\sim 1.0 ~fb^{-1}$ although we have also discussed briefly the prospects at LHC-10 $TeV$. We focus on the parameter space yielding relatively light squark and gluinos consistent with the darkmatter relic density data and the LEP bounds on the lightest Higgs scalar mass. This parameter space is only allowed for non-vanishing trilinear soft breaking term $A_0$. A significant region of the parameter space with large to moderate negative values of $A_0$ consistent with the stability of the scalar potential and relic density production via neutralino annihilation and/or neutralino - stau coannihilation yields observable signal via the jets + missing transverse energy channel. The one lepton + jets + missing energy signal is also viable over a smaller but non-trivial parameter space. The ratio of the size of the two signals - free from theoretical uncertainties - may distinguish between different relic density generating mechanisms. With efficient $\tau$-tagging facilities at 7 $TeV$ the discriminating power may increase significantly. We also comment on other dark matter relic density allowed mSUGRA scenarios and variants there of in the context of LHC-7 $TeV$.Comment: Brief comments on signals at 7 TeV in the Higgs funnel region of mSUGRA, models with non universal scalar and gaugino masses have been added. Accepted for publication in PR

Mitigation of the LHC Inverse Problem

The LHC inverse problem refers to the difficulties in determining the parameters of an underlying theory from data (to be) taken by the LHC experiments: if they find signals of new physics, and an underlying theory is assumed, could its parameters be determined uniquely, or do different parameter choices give indistinguishable experimental signatures? This inverse problem was studied before for a supersymmetric Standard Model with 15 free parameters. This earlier study found 283 indistinguishable pairs of parameter choices, called degenerate pairs, even if backgrounds are ignored. We can resolve all but 23 of those pairs by constructing a true \chi^2 distribution using mostly counting observables. The elimination of systematic errors would even allow separating the residual degeneracies. Taking the Standard Model background into account we still can resolve 237 of the 283 "degenerate" pairs. This indicates that (some of) our observables should also be useful for the purpose of determining the values of SUSY parameters.Comment: 32 pages, 13 figures, typo in (3.6) corrected, version to appear in Phys. Rev.

Comparison of clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with acute non compressive nucleus pulposus extrusion

Abstract OBJECTIVE To compare clinical signs and outcomes between dogs with presumptive ischemic myelopathy and dogs with presumptive acute noncompressive nucleus pulposus extrusion (ANNPE). DESIGN Retrospective study. ANIMALS 51 dogs with ischemic myelopathy and 42 dogs with ANNPE examined at 1 referral hospital. PROCEDURES Medical records and MRI sequences were reviewed for dogs with a presumptive antemortem diagnosis of ischemic myelopathy or ANNPE. Information regarding signalment, clinical signs at initial examination, and short-term outcome was retrospectively retrieved from patient records. Long-term outcome information was obtained by telephone communication with referring or primary-care veterinarians and owners. RESULTS Compared with the hospital population, English Staffordshire Bull Terriers and Border Collies were overrepresented in the ischemic myelopathy and ANNPE groups, respectively. Dogs with ANNPE were significantly older at disease onset and were more likely to have a history of vocalization at onset of clinical signs, have spinal hyperesthesia during initial examination, have a lesion at C1-C5 spinal cord segments, and be ambulatory at hospital discharge, compared with dogs with ischemic myelopathy. Dogs with ischemic myelopathy were more likely to have a lesion at L4-S3 spinal cord segments and have long-term fecal incontinence, compared with dogs with ANNPE. However, long-term quality of life and outcome did not differ between dogs with ischemic myelopathy and dogs with ANNPE. CONCLUSIONS AND CLINICAL RELEVANCE Results revealed differences in clinical signs at initial examination between dogs with ischemic myelopathy and dogs with ANNPE that may aid clinicians in differentiating the 2 conditions.</jats:p

Electroweak Contributions to Squark Pair Production at the LHC

In this paper we compute electroweak contributions to the production of squark pairs at hadron colliders. These include the exchange of electroweak gauge bosons in the s-channel as well as electroweak gaugino exchange in the t- and/or u-channel. In many cases these can interfere with the dominant QCD contributions. As a result, we find sizable contributions to the production of two SU(2) doublet squarks. At the LHC, they amount to 10 to 20% for typical mSUGRA (or CMSSM) scenarios, but in more general scenarios they can vary between -40 and +55%, depending on size and sign of the SU(2) gaugino mass. The electroweak contribution to the total squark pair production rate at the LHC is about 3.5 times smaller.Comment: 28 pages, 9 figure

Exploring compressed supersymmetry with same-sign top quarks at the Large Hadron Collider

In compressed supersymmetry, a light top squark naturally mediates efficient neutralino pair annihilation to govern the thermal relic abundance of dark matter. I study the LHC signal of same-sign leptonic top-quark decays from gluino and squark production, which follows from gluino decays to top plus stop followed by the stop decaying to a charm quark and the LSP in these models. Measurements of the numbers of jets with heavy-flavor tags in the same-sign lepton events can be used to confirm the origin of the signal. Summed transverse momentum observables provide an estimate of an effective superpartner mass, which is correlated with the gluino mass. Measurements of invariant mass endpoints from the visible products of gluino decays do not allow direct determination of superpartner masses, but can place constraints on them, including lower bounds on the gluino mass as a function of the top-squark mass.Comment: 22 pages. v2: Discussion of competition between 2-body and 4-body stop decays corrected. References adde