876 research outputs found
Security in Wireless Sensor Networks: Issues and Challenges
Wireless Sensor Network (WSN) is an emerging technology that shows great
promise for various futuristic applications both for mass public and military.
The sensing technology combined with processing power and wireless
communication makes it lucrative for being exploited in abundance in future.
The inclusion of wireless communication technology also incurs various types of
security threats. The intent of this paper is to investigate the security
related issues and challenges in wireless sensor networks. We identify the
security threats, review proposed security mechanisms for wireless sensor
networks. We also discuss the holistic view of security for ensuring layered
and robust security in wireless sensor networks.Comment: 6 page
Peacock Bundles: Bundle Coloring for Graphs with Globality-Locality Trade-off
Bundling of graph edges (node-to-node connections) is a common technique to
enhance visibility of overall trends in the edge structure of a large graph
layout, and a large variety of bundling algorithms have been proposed. However,
with strong bundling, it becomes hard to identify origins and destinations of
individual edges. We propose a solution: we optimize edge coloring to
differentiate bundled edges. We quantify strength of bundling in a flexible
pairwise fashion between edges, and among bundled edges, we quantify how
dissimilar their colors should be by dissimilarity of their origins and
destinations. We solve the resulting nonlinear optimization, which is also
interpretable as a novel dimensionality reduction task. In large graphs the
necessary compromise is whether to differentiate colors sharply between locally
occurring strongly bundled edges ("local bundles"), or also between the weakly
bundled edges occurring globally over the graph ("global bundles"); we allow a
user-set global-local tradeoff. We call the technique "peacock bundles".
Experiments show the coloring clearly enhances comprehensibility of graph
layouts with edge bundling.Comment: Appears in the Proceedings of the 24th International Symposium on
Graph Drawing and Network Visualization (GD 2016
Meso-Scale Process Modelling Strategies for Pultrusion of Unidirectional Profiles
The resin injection pultrusion is an automated composite manufacturing method in which the resin is injected in a chamber. The flow and the thermo chemical mechanical (TCM) models have been studied for the pultrusion process to improve the reliability of the final products. Flow models are needed to understand and describe the fiber impregnation, filling time and presence of dry spots or voids. Also pressure field in the injection chamber can be estimated with flow models. TCM models are needed to predict residual stress distributions and to optimize the process conditions. A non-uniform fiber distribution strongly affects the results of both types of models. In this study, different strategies are carried out to implement non-uniform fiber distributions into the models. The cross-sectional image and fiber distribution of a 19×19 mm glass fiber reinforced polyester unidirectional pultruded composite is used. Non-uniform fiber distribution is observed and implemented into the flow model by means of permeability variations. The results of this study are compared with uniform fiber distribution results. In the TCM model, the non-uniform fiber volume content is implemented within different sized patches. The results show that the non-uniform fiber fraction should be taken into account for the process models of composites in order to capture the local process induced stresses and probability of dry spots or voids due to poor fiber impregnation
Turner syndrome and associated problems in turkish children: A multicenter study
Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in humans1-3. Recently, ADCY3 (adenylyl cyclase 3) gene mutations have been implicated in obesity4,5. ADCY3 localizes to the primary cilia of neurons 6 , organelles that function as hubs for select signaling pathways. Mutations that disrupt the functions of primary cilia cause ciliopathies, rare recessive pleiotropic diseases in which obesity is a cardinal manifestation 7 . We demonstrate that MC4R colocalizes with ADCY3 at the primary cilia of a subset of hypothalamic neurons, that obesity-associated MC4R mutations impair ciliary localization and that inhibition of adenylyl cyclase signaling at the primary cilia of these neurons increases body weight. These data suggest that impaired signaling from the primary cilia of MC4R neurons is a common pathway underlying genetic causes of obesity in humans
Perspectives on care and communication involving incurably ill Turkish and Moroccan patients, relatives and professionals: a systematic literature review
<p>Abstract</p> <p>Background</p> <p>Our aim was to obtain a clearer picture of the relevant care experiences and care perceptions of incurably ill Turkish and Moroccan patients, their relatives and professional care providers, as well as of communication and decision-making patterns at the end of life. The ultimate objective is to improve palliative care for Turkish and Moroccan immigrants in the Netherlands, by taking account of socio-cultural factors in the guidelines for palliative care.</p> <p>Methods</p> <p>A systematic literature review was undertaken. The data sources were seventeen national and international literature databases, four Dutch journals dedicated to palliative care and 37 websites of relevant national and international organizations. All the references found were checked to see whether they met the structured inclusion criteria. Inclusion was limited to publications dealing with primary empirical research on the relationship between socio-cultural factors and the health or care situation of Turkish or Moroccan patients with an oncological or incurable disease. The selection was made by first reading the titles and abstracts and subsequently the full texts. The process of deciding which studies to include was carried out by two reviewers independently. A generic appraisal instrument was applied to assess the methodological quality.</p> <p>Results</p> <p>Fifty-seven studies were found that reported findings for the countries of origin (mainly Turkey) and the immigrant host countries (mainly the Netherlands). The central themes were experiences and perceptions of family care, professional care, end-of-life care and communication. Family care is considered a duty, even when such care becomes a severe burden for the main female family caregiver in particular. Professional hospital care is preferred by many of the patients and relatives because they are looking for a cure and security. End-of-life care is strongly influenced by the continuing hope for recovery. Relatives are often quite influential in end-of-life decisions, such as the decision to withdraw or withhold treatments. The diagnosis, prognosis and end-of-life decisions are seldom discussed with the patient, and communication about pain and mental problems is often limited. Language barriers and the dominance of the family may exacerbate communication problems.</p> <p>Conclusions</p> <p>This review confirms the view that family members of patients with a Turkish or Moroccan background have a central role in care, communication and decision making at the end of life. This, in combination with their continuing hope for the patient’s recovery may inhibit open communication between patients, relatives and professionals as partners in palliative care. This implies that organizations and professionals involved in palliative care should take patients’ socio-cultural characteristics into account and incorporate cultural sensitivity into care standards and care practices<it>.</it></p
High-K volcanism in the Afyon region, western Turkey: from Si-oversaturated to Si-undersaturated volcanism
Volcanic rocks of the Afyon province (eastern
part of western Anatolia) make up a multistage potassic and ultrapotassic alkaline series dated from 14 to 12 Ma. The early-stage Si-oversaturated volcanic rocks around the Afyon city and further southward are trachyandesitic volcanic activity (14.23 ± 0.09 Ma). Late-stage Si-undersaturated volcanism in the southernmost part of the Afyon volcanic province took place in three episodes inferred from their stratigraphic relationships and ages. Melilite–
leucitites (11.50 ± 0.03 Ma), spotted rachyandesites, tephryphonolites and lamproites (11.91 ± 0.13 Ma) formed in the first episode; trachyandesites in the second episode and finally phonotephrites, phonolite, basaltic trachyandesites and nosean-bearing trachyandesites during the last episode.
The parameter Q [normative q-(ne + lc + kls + ol)] of western Anatolia volcanism clearly decreased southward with time becoming zero in the time interval 10–15 Ma.
The magmatism experienced a sudden change in the extent of Si saturation after 14 Ma, during late-stage volcanic activity of Afyon volcanic province at around 12 Ma, though there was some coexistence of Si-oversaturated and Si-undersaturated magmas during the whole life of Afyon volcanic province
Evolving Neural Networks Applied to Predator-Evader Problem
The creation of strategies to meet abstract goals is an important behavior exhibited by natural organisms. A situation requiring the development of such strategies is the predator-evader problem. To study this problem, Khepera robots are chosen as the competing agents. Using computer simulations the evolution of the adaptive behavior is studied in a predator-evader interaction. A bilaterally symmetrical multilayer perceptron neural network architecture with evolvable weights is used to model the “brains” of the agents. Evolutionary programming is employed to evolve the predator for developing adaptive strategies to meet its goals. To study the effect of learning on evolution a self-organizing map (SOM) is added to the architecture, it is trained continuously and all the predators can access its weights. The results of these two different approaches are compared
Unsteady Flow Produced by Oscillations of Eccentric Rotating Disks
While the disks are initially rotating eccentrically, the unsteady flow caused by their oscillations in their own planes and in the opposite directions is studied. The analytical solutions to the problem are obtained for both small and large times, and thus the velocity field is determined for every value of time. The variations of all the parameters on the flow are scrutinized by means of the graphical representations. In particular, the effect of the ratio of the frequency of oscillation to the angular velocity of the disks is analyzed. The dependence of the oscillations in both - and -directions on the flow is examined. The influence of the Reynolds number is also investigated
A Review on the Mechanical Modeling of Composite Manufacturing Processes
The increased usage of fiber reinforced polymer composites in load bearing applications requires a detailed understanding of the process induced residual stresses and their effect on the shape distortions. This is utmost necessary in order to have more reliable composite manufacturing since the residual stresses alter the internal stress level of the composite part during the service life and the residual shape distortions may lead to not meeting the desired geometrical tolerances. The occurrence of residual stresses during the manufacturing process inherently contains diverse interactions between the involved physical phenomena mainly related to material flow, heat transfer and polymerization or crystallization. Development of numerical process models is required for virtual design and optimization of the composite manufacturing process which avoids the expensive trial-and-error based approaches. The process models as well as applications focusing on the prediction of residual stresses and shape distortions taking place in composite manufacturing are discussed in this study. The applications on both thermoset and thermoplastic based composites are reviewed in detail
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