Comparative morphometric analysis of bloodstream and lymph forms of Trypanosoma (T.) brucei brucei grown in vitro and in vivo

The fine structure of bloodstream forms of Trypanosoma brucei cultivated in vitro, and of trypanosomes from lymph and blood of mammalian hosts, was compared morphometrically. The cell volume, quantitative parameters of the mitochondrion and of glycosomes were mainly investigated. A Coulter Channelyzer was used for the first time to measure the mean cell volume of living parasites. In vitro, the monomorphic trypanosomes between the feeder layer cells showed lower values for mitochondrial parameters than the slightly pleomorphic forms from the supernatant medium. Trypanosomes in culture were very similar morphologically to forms from lymph nodes of rats. Despite some morphometric differences between cultivated blood stream forms and those grown in vivo, the similarity of both populations was clear. Both populations, however, differed significantly from stages found in the vector or from procyclic culture form

Performance and evaluation of two liquid-metal pumps for sodium-potassium service

Performance tests on liquid metal pumps for sodium potassium loop

Hyperfine, rotational and Zeeman structure of the lowest vibrational levels of the 87^{87}Rb2_2 \tripletex state

We present the results of an experimental and theoretical study of the electronically excited \tripletex state of $^{87}$Rb$_2$ molecules. The vibrational energies are measured for deeply bound states from the bottom up to $v'=15$ using laser spectroscopy of ultracold Rb$_2$ Feshbach molecules. The spectrum of each vibrational state is dominated by a 47\,GHz splitting into a \cog and \clg component caused mainly by a strong second order spin-orbit interaction. Our spectroscopy fully resolves the rotational, hyperfine, and Zeeman structure of the spectrum. We are able to describe to first order this structure using a simplified effective Hamiltonian.Comment: 10 pages, 7 figures, 2 table

The effects of donepezil in Alzheimer's disease - Results from a multinational trial

Donepezil has been shown to be well tolerated and to improve cognition and global function in patients with mild to moderately severe Alzheimer's disease (AD). The current trial was undertaken to investigate further the efficacy and safety of donepezil, in a multinational setting, in patients with mild to moderately severe AD. This 30-week, placebo-controlled, parallel-group study consisted of a 24-week, double-blind treatment phase followed by a 6-week, single-blind, placebo washout. Eight hundred and eighteen patients with mild to moderately severe AD were randomly allocated to treatment with single, daily doses of 5 or 10 mg donepezil, or placebo. The two primary efficacy measures were: a cognitive performance test, the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) and a global evaluation, the Clinician's Interview-Based Impression of Change with caregiver input (CIBIC plus). Secondary outcome measures included the Sum of the Boxes of the Clinical Dementia Rating Scale (CDR-SB), a modified Interview for Deterioration in Daily living activities in Dementia (IDDD) and a patient-rated quality of life assessment. Statistically significant improvements in cognitive and global function were observed, as evaluated by ADAS-cog and CIBIC plus, respectively, in both the 5 and 10 mg/day donepezil groups, compared with placebo. Treatment-associated changes were also observed in functional skills, as shown by improved scores on the CDR-SB and the complex-tasks component of the IDDD. A dose-response effect was evident, with the 10 mg/day donepezil group demonstrating greater benefits in all outcome measures than the 5 mg/day group. Donepezil was well tolerated by this patient population and did not produce any clinically significant laboratory test abnormalities. The results of this study confirm that donepezil is effective and well tolerated in treating the symptoms of mild to moderately severe AD

Characterization of Trypanosoma brucei isolated from lymph nodes of rats

Forms of Trypanosoma brucei isolated from lymph nodes of cyclically or intravenously infected rats, at different stages of infection, were morphologically compared with the corresponding bloodstream forms. Unlike the pleomorphic bloodstream trypanosome population, the lymph node trypanosome population was essentially monomorphic and resembled the slender forms of the bloodstream. Values for the morphometric parameters indicated a position between the slender and the stumpy forms. The number of trypanosomes/ml of blood showed the well-known periodic fluctuations while the number of trypanosomes/g of lymph node remained fairly constant. Serology revealed that lymph node trypanosome populations differed antigenically from the trypanosome populations isolated simultaneously from the bloodstrea

Atom-molecule dark states in a Bose-Einstein condensate

We have created a dark quantum superposition state of a Rb Bose-Einstein condensate (BEC) and a degenerate gas of Rb$_2$ ground state molecules in a specific ro-vibrational state using two-color photoassociation. As a signature for the decoupling of this coherent atom-molecule gas from the light field we observe a striking suppression of photoassociation loss. In our experiment the maximal molecule population in the dark state is limited to about 100 Rb$_2$ molecules due to laser induced decay. The experimental findings can be well described by a simple three mode model.Comment: 4 pages, 6 figure

Collective oscillations of a Fermi gas in the unitarity limit: Temperature effects and the role of pair correlations

We present detailed measurements of the frequency and damping of three different collective modes in an ultracold trapped Fermi gas of $^6$Li atoms with resonantly tuned interactions. The measurements are carried out over a wide range of temperatures. We focus on the unitarity limit, where the scattering length is much greater than all other relevant length scales. The results are compared to theoretical calculations that take into account Pauli blocking and pair correlations in the normal state above the critical temperature for superfluidity. We show that these two effects nearly compensate each other and the behavior of the gas is close to the one of a classical gas.Comment: 8 pages, 5 figure

Long Distance Transport of Ultracold Atoms using a 1D optical lattice

We study the horizontal transport of ultracold atoms over macroscopic distances of up to 20 cm with a moving 1D optical lattice. By using an optical Bessel beam to form the optical lattice, we can achieve nearly homogeneous trapping conditions over the full transport length, which is crucial in order to hold the atoms against gravity for such a wide range. Fast transport velocities of up to 6 m/s (corresponding to about 1100 photon recoils) and accelerations of up to 2600 m/s2 are reached. Even at high velocities the momentum of the atoms is precisely defined with an uncertainty of less than one photon recoil. This allows for construction of an atom catapult with high kinetic energy resolution, which might have applications in novel collision experiments.Comment: 15 pages, 8 figure