Pion Interferometry From A Relativistic Fluid With A First Order Phase Transition In CERN-SPS 158 GeV/A Pb+Pb Collisions

We investigate pion source sizes through the Yano-Koonin-Podgoretski\u{\i} (YKP) parametrization for the Hanbury-Brown Twiss (HBT) effect in the CERN-SPS 158 GeV/A central collisions. We calculate two-particle correlation functions numerically based on a (3+1)-dimensional relativistic hydrodynamics with a first order phase transition and analyze the pair momentum dependence of the HBT radii extracted from the YKP parametrization in detail. We find that even in the case of a first order phase transition, expansion and the surface dominant freeze-out make the source in the hydrodynamical model opaque significantly. Consequently, the interpretation of the temporal radius parameter as the time duration becomes unavailable for the hydrodynamical model.Comment: 5 pages, LaTeX with six eps figures, Contribution to 'International Workshop XXVIII on Gross Properties of Nuclei And Nuclear Excitations'. Hirchegg, Austria, Jan 16-22, 200

Knowledge management and human trafficking: using conceptual knowledge representation, text analytics and open-source data to combat organized crime

Globalization, the ubiquity of mobile communications and the rise of the web have all expanded the environment in which organized criminal entities are conducting their illicit activities, and as a result the environment that law enforcement agencies have to police. This paper triangulates the capability of open-source data analytics, ontological knowledge representation and the wider notion of knowledge management (KM) in order to provide an effective, interdisciplinary means to combat such threats, thus providing law enforcement agencies (LEA’s) with a foundation of competitive advantage over human trafficking and other organized crime

Charmonium properties in hot quenched lattice QCD

We study the properties of charmonium states at finite temperature in quenched QCD on large and fine isotropic lattices. We perform a detailed analysis of charmonium correlation and spectral functions both below and above $T_c$. Our analysis suggests that both S wave states ($J/\psi$ and $\eta_c$) and P wave states ($\chi_{c0}$ and $\chi_{c1}$) disappear already at about $1.5 T_c$. The charm diffusion coefficient is estimated through the Kubo formula and found to be compatible with zero below $T_c$ and approximately $1/\pi T$ at $1.5 T_c\lesssim T\lesssim 3 T_c$.Comment: 32 pages, 19 figures, typo corrected, discussions on isotropic vs anisotropic lattices expanded, published versio

Analysis of one- and two-particle spectra at RHIC based on a hydrodynamical model

We calculate the one-particle hadronic spectra and correlation functions of pions based on a hydrodynamical model. Parameters in the model are so chosen that the one-particle spectra reproduce experimental results of $\sqrt{s}=130A$GeV Au+Au collisions at RHIC. Based on the numerical solution, we discuss the space-time evolution of the fluid. Two-pion correlation functions are also discussed. Our numerical solution suggests the formation of the quark-gluon plasma with large volume and low net baryon density.Comment: LaTeX, 4pages, 4 figures. To appear in the proceedings of Fourth International Conference on Physics and Astrophysics of Quark-Gluon Plasma (ICPAQGP-2001), Nov 26-30, 2001, Jaipur, Indi

Live imaging of whole mouse embryos during gastrulation : migration analyses of epiblast and mesodermal cells

During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan. The precise details of these movements, however, are sometimes elusive, because of the limitations in live imaging. To overcome this problem, we developed techniques to enable observation of living mouse embryos with digital scanned light sheet microscope (DSLM). The achieved deep and high time-resolution images of GFP-expressing nuclei and following 3D tracking analysis revealed the following findings: (i) Interkinetic nuclear migration (INM) occurs in the epiblast at embryonic day (E)6 and 6.5. (ii) INM-like migration occurs in the E5.5 embryo, when the epiblast is a monolayer and not yet pseudostratified. (iii) Primary driving force for INM at E6.5 is not pressure from neighboring nuclei. (iv) Mesodermal cells migrate not as a sheet but as individual cells without coordination

Progression of myopathology in Kearns-Sayre syndrome

We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy

Organizational impact of evidence-informed decision making training initiatives : a case study comparison of two approaches

Background The impact of efforts by healthcare organizations to enhance the use of evidence to improve organizational processes through training programs has seldom been assessed. We therefore endeavored to assess whether and how the training of mid- and senior-level healthcare managers could lead to organizational change. Methods We conducted a theory-driven evaluation of the organizational impact of healthcare leaders’ participation in two training programs using a logic model based on Nonaka’s theory of knowledge conversion. We analyzed six case studies nested within the two programs using three embedded units of analysis (individual, group and organization). Interviews were conducted during intensive one-week data collection site visits. A total of 84 people were interviewed. Results We found that the impact of training could primarily be felt in trainees’ immediate work environments. The conversion of attitudes was found to be easier to achieve than the conversion of skills. Our results show that, although socialization and externalization were common in all cases, a lack of combination impeded the conversion of skills. We also identified several individual, organizational and program design factors that facilitated and/or impeded the dissemination of the attitudes and skills gained by trainees to other organizational members. Conclusions Our theory-driven evaluation showed that factors before, during and after training can influence the extent of skills and knowledge transfer. Our evaluation went further than previous research by revealing the influence—both positive and negative—of specific organizational factors on extending the impact of training programs

Apm4, the mu subunit of yeast AP-2 interacts with Pkc1, and mutation of the Pkc1 consensus phosphorylation site Thr176 inhibits AP-2 recruitment to endocytic sites.

The AP-2 endocytic adaptor has been extensively characterized in mammalian cells and is considered to play a role both in cargo binding and in formation of endocytic sites. However, despite our detailed knowledge of mechanistic aspects of endocytic complex assembly and disassembly in the model organism Saccharomyces cerevisiae, no function of AP-2 had been described in wild-type yeast under normal growth conditions. A recent study however revealed that disruption of the complex caused by deletion of the gene encoding its mu subunit (APM4) caused defects in cell polarity such that responses to pheromone, nutritional status and cell wall damage were affected. Furthermore, a homozygous deletion of the mu subunit gene in Candida albicans affected its ability to grow hyphae. Direct binding to the yeast cell wall stress sensor Mid2 was detected, and in an apm4 deletion strain Mid2 showed reduced re-localization to the mother bud neck region following cell wall damage with calcofluor or to the mating projection tip. Here we demonstrate an interaction between Apm4 and the yeast cell wall integrity pathway component Pkc1 and show that mutation of the predicted Pkc1 site in the Apm4 hinge region affects recruitment of the AP-2 complex to endocytic sites

Hydrodynamical evolution near the QCD critical end point

Hydrodynamical calculations have been successful in describing global observables in ultrarelativistic heavy ion collisions, which aim to observe the production of the quark-gluon plasma. On the other hand, recently, a lot of evidence that there exists a critical end point (CEP) in the QCD phase diagram has been accumulating. Nevertheless, so far, no equation of state with the CEP has been employed in hydrodynamical calculations. In this paper, we construct the equation of state with the CEP on the basis of the universality hypothesis and show that the CEP acts as an attractor of isentropic trajectories. We also consider the time evolution in the case with the CEP and discuss how the CEP affects the final state observables, such as the correlation length, fluctuation, chemical freezeout, kinetic freezeout, and so on. Finally, we argue that the anomalously low kinetic freezeout temperature at the BNL Relativistic Heavy Ion Collider suggests the possibility of the existence of the CEP.Comment: 13 pages, 12 figures, accepted for publication in Physical Review