Simulation experiments for performance analysis of multiple-bus multiprocessor systems with nonexponential service times

A simulation model (program) is constructed for performance analysis of multiple-bus multiprocessor systems with shared memories. It is assumed that the service time of the common memory is either hypo- or hyperexponentially distributed. Process ing efficiency is used as the performance index. To investigate the effects of different service time distributions on the system perfor mance, comparative results are obtained for a large set of input parameters. The simulation results show that the error in approx imating the memory access time by an exponentially distributed random variable is less than 6% if the coefficient of variation is less than 1, but it increases drastically with this factor if it is greater than 1.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68518/2/10.1177_003754978905200104.pd

Off-axis Hartmann wavefront sensing for the GMT-Consortium Large Earth Finder (G-CLEF) red camera optics

The Hartmann test is a method used to measure the wavefront error in a focal optical system, wherein a mask with a pattern of small holes is placed at the system's aperture stop. By taking an image at a defocused plane, the differences between the ideal and real positions of the reimaged holes (called the transverse ray aberrations) can be measured, which can then be used to estimate the wavefront error. However, the Hartmann test is usually used with an on-axis field. In this paper, we present a wavefront sensing method which generalizes the classical Hartmann test for off-axis field angles and arbitrary reference wavefronts. Our method involves taking images at two defocused planes, and then using the real reimaged hole positions on both planes to estimate the trajectories of rays from the system's exit pupil, at which the reference wavefront is situated. We then propagate the rays forward from the reference wavefront to one of the two defocused planes, in order to find the ideal reimaged hole positions, from which we can compute transverse ray aberrations. We derive and solve a pair of nonlinear partial differential equations relating transverse ray aberrations to wavefront error, using Zernike decomposition and nonlinear least squares. Our method has been verified on simulated data from the 7-lens f/2.25 red camera system of the GMT-Consortium Large Earth Finder (G-CLEF), a high resolution optical echelle spectrograph which will be a first light instrument for the Giant Magellan Telescope (GMT).Comment: 18 pages, 23 figures, SPIE Astronomical Telescopes + Instrumentation 202

Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release

Micelles are colloidal particles with a size around 5–100 nm which are currently under investigation as carriers for hydrophobic drugs in anticancer therapy. Currently, five micellar formulations for anticancer therapy are under clinical evaluation, of which Genexol-PM has been FDA approved for use in patients with breast cancer. Micelle-based drug delivery, however, can be improved in different ways. Targeting ligands can be attached to the micelles which specifically recognize and bind to receptors overexpressed in tumor cells, and chelation or incorporation of imaging moieties enables tracking micelles in vivo for biodistribution studies. Moreover, pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release. The combination of these approaches will further improve specificity and efficacy of micelle-based drug delivery and brings the development of a ‘magic bullet’ a major step forward

Thiostrepton-Nanomedicine, a TLR9 Inhibitor, Attenuates Sepsis-Induced Inflammation in Mice

Sepsis is a life-threatening clinical condition caused by infection and transposition of pathogens and pathogen-associated molecular patterns (PAMPs) into the host bloodstream. During sepsis, activation of toll-like receptors (TLRs) on immune cells triggers the release of pro-inflammatory cytokines and overstimulates the production of vasodilatory mediators such as nitric oxide (NO). These vascular changes lead to widespread inflammation, tissue damage, multiple organ failure, and often death. New therapeutic options are urgently needed. To this end, thiostrepton (TST) has emerged as a candidate for sepsis treatment due to its action as an antibiotic and anti-inflammatory molecule (TLR7-9 inhibitor). Reports in the literature suggest that TLR9 inhibition substantially suppresses the excessive host inflammatory response and attenuates sepsis-induced mortality in the cecal ligation and puncture (CLP) murine model of sepsis. However, to the best of our knowledge, TST has never been directly tested as a therapeutic option for the management of sepsis, possibly due to its low water solubility and drug delivery issues. These facts prompted us to test the central hypothesis that TST encapsulated in phospholipid sterically stabilized micelles (TST-SSM) could be developed into a novel treatment for sepsis. Thus, using our published method of encapsulating the hydrophobic antibiotic TST-SSM, we evaluated the in vivo efficacy of TST-SSM nanomedicine in the murine model of polymicrobial sepsis. We found that TST-SSM increased the median survival of CLP-induced septic mice from 31 to 44 hr by reducing the bacterial burden in the blood and peritoneal lavage. Moreover, plasma levels of pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor-alpha) and NO derivatives were also reduced, whereas renal and hepatic function biomarkers creatinine and aspartate transferase were significantly improved. In conclusion, we identified that TST-SSM nanomedicine has significant potential as a therapeutic agent for sepsis management, primarily due to its anti-inflammatory and antibiotic properties