Discovery of an Isolated Compact Object at High Galactic Latitude

We report discovery of a compact object at high Galactic latitude. The object was initially identified as a ROSAT All-Sky Survey Bright Source Catalog X-ray source, 1RXS J141256.0+792204, statistically likely to possess a high X-ray to optical flux ratio. Further observations using {\em Swift}, Gemini-North, and the Chandra X-ray Observatory refined the source position and confirmed the absence of any optical counterpart to an X-ray to optical flux ratio of F_X/F_V > 8700 (3 sigma). Interpretation of 1RXS J141256.0+792204 -- which we have dubbed Calvera -- as a typical X-ray-dim isolated neutron star would place it at z ~ 5.1 kpc above the Galactic disk -- in the Galactic halo -- implying that it either has an extreme space velocity (v_z >~ 5100 km s-1) or has failed to cool according to theoretical predictions. Interpretations as a persistent anomalous X-ray pulsar, or a ``compact central object'' present conflicts with these classes' typical properties. We conclude the properties of Calvera are most consistent with those of a nearby (80 to 260 pc) radio pulsar, similar to the radio millisecond pulsars of 47 Tuc, with further observations required to confirm this classification. If it is a millisecond pulsar, it has an X-ray flux equal to the X-ray brightest millisecond pulsar (and so is tied for highest flux); is the closest northern hemisphere millisecond pulsar; and is potentially the closest known millisecond pulsar in the sky, making it an interesting target for X-ray-study, a radio pulsar timing array, and LIGO.Comment: ApJ, in press. We are grateful to the anonymous referee, who pointed us toward a better XRT response matrix which changes our quantitative conclusions somewha

A systems biology analysis of brain microvascular endothelial cell lipotoxicity.

BackgroundNeurovascular inflammation is associated with a number of neurological diseases including vascular dementia and Alzheimer's disease, which are increasingly important causes of morbidity and mortality around the world. Lipotoxicity is a metabolic disorder that results from accumulation of lipids, particularly fatty acids, in non-adipose tissue leading to cellular dysfunction, lipid droplet formation, and cell death.ResultsOur studies indicate for the first time that the neurovascular circulation also can manifest lipotoxicity, which could have major effects on cognitive function. The penetration of integrative systems biology approaches is limited in this area of research, which reduces our capacity to gain an objective insight into the signal transduction and regulation dynamics at a systems level. To address this question, we treated human microvascular endothelial cells with triglyceride-rich lipoprotein (TGRL) lipolysis products and then we used genome-wide transcriptional profiling to obtain transcript abundances over four conditions. We then identified regulatory genes and their targets that have been differentially expressed through analysis of the datasets with various statistical methods. We created a functional gene network by exploiting co-expression observations through a guilt-by-association assumption. Concomitantly, we used various network inference algorithms to identify putative regulatory interactions and we integrated all predictions to construct a consensus gene regulatory network that is TGRL lipolysis product specific.ConclusionSystem biology analysis has led to the validation of putative lipid-related targets and the discovery of several genes that may be implicated in lipotoxic-related brain microvascular endothelial cell responses. Here, we report that activating transcription factors 3 (ATF3) is a principal regulator of TGRL lipolysis products-induced gene expression in human brain microvascular endothelial cell

Use of ordination and classification procedures to evaluate phytoplankton communities during Superflux II

Cluster analysis and an ordination procedure were performed on two data matrices to investigate real and environmental spatial relationships. Multiple regression analysis was used to relate the measured environmental variables to the phytoplankton community changes. Qualitative type phytoplankton data proved to be less structured in both of these spaces, relative to the biomass data. The salinity gradients of the northern transects covaried significantly with the phytoplankton association changes. In the southern transects the light variable was most important in explaining the variance in the ordination axes. These data suggest the close relationships between phytoplankton community changes and the physical hydrology of the area

Chandra Observations of 1RXS J141256.0+792204 (Calvera)

We report the results of a 30 ks Chandra ACIS-S observation of the isolated compact object 1RXS J141256.0+792204 (Calvera). The X-ray spectrum is adequately described by an absorbed neutron star hydrogen atmosphere model with an effective temperature at infinity of 88.3 +/- 0.8 eV and radiation radius at infinity of 4.1 +/- 0.1 km/kpc. The best-fit blackbody spectrum yields parameters consistent with previous measurements; although the fit itself is not statistically acceptable, systematic uncertainties in the pile-up correction may contribute to this. We find marginal evidence for narrow spectral features in the X-ray spectrum between 0.3 and 1.0 keV. In one interpretation, we find evidence at 81%-confidence for an absorption edge at 0.64 (+0.08) (-0.06) keV with an equivalent width of ~70 eV; if this feature is real, it is reminiscent of features seen in the isolated neutron stars RX J1605.3+3249, RX J0720.4-3125, and 1RXS J130848.6+212708 (RBS 1223). In an alternative approach, we find evidence at 88%-confidence for an unresolved emission line at energy 0.53 +/- 0.02 keV, with an equivalent width of ~28 eV; the interpretation of this feature, if real, is uncertain. We search for coherent pulsations up to the Nyquist frequency of 1.13 Hz and set an upper limit of 8.0% rms on the strength of any such modulation. We derive an improved position for the source and set the most rigorous limits to-date on any associated extended emission on arcsecond scales. Our analysis confirms the basic picture of Calvera as the first isolated compact object in the ROSAT/Bright Source Catalog discovered in six years, the hottest such object known, and an intriguing target for multiwavelength study.Comment: Submitted to ApJ. AASTeX, 19 pages, 2 figure

Microlensing of gamma ray bursts by stars and MACHOs

The microlensing interpretation of the optical afterglow of GRB 000301C seems naively surprising, since a simple estimate of the stellar microlensing rate gives less than one in four hundred for a flat Omega_Lambda=0.7 cosmology, whereas one event was seen in about thirty afterglows. Considering baryonic MACHOs making up half of the baryons in the universe, the microlensing probability per burst can be roughly 5% for a GRB at redshift z=2. We explore two effects that may enhance the probability of observing microlensed gamma-ray burst afterglows: binary lenses and double magnification bias. We find that the consideration of binary lenses can increase the rate only at the ~15% level. On the other hand, because gamma-ray bursts for which afterglow observations exist are typically selected based on fluxes at widely separated wavebands which are not necessarily well correlated (e.g. localization in X-ray, afterglow in optical/infrared), magnification bias can operate at an enhanced level compared to the usual single-bias case. We find that existing estimates of the slope of the luminosity function of gamma-ray bursts, while as yet quite uncertain, point to enhancement factors of more than three above the simple estimates of the microlensing rate. We find that the probability to observe at least one microlensing event in the sample of 27 measured afterglows can be 3-4% for stellar lenses, or as much as 25 Omega_lens for baryonic MACHOs. We note that the probability to observe at least one event over the available sample of afterglows is significant only if a large fraction of the baryons in the universe are condensed in stellar-mass objects. (ABRIDGED)Comment: 22 pages, 4 figures, 2 table

The X-ray Spectrum and Light Curve of Supernova 1995N

We report on multi-epoch X-ray observations of the Type IIn (narrow emission line) supernova SN 1995N with the ROSAT and ASCA satellites. The January 1998 ASCA X-ray spectrum is well fitted by a thermal bremsstrahlung (kT~10 keV, N_H~6e20 cm^-2) or power-law (alpha~1.7, N_H~1e21 cm^-2) model. The X-ray light curve shows evidence for significant flux evolution between August 1996 and January 1998: the count rate from the source decreased by 30% between our August 1996 and August 1997 ROSAT observations, and the X-ray luminosity most likely increased by a factor of ~2 between our August 1997 ROSAT and January 1998 ASCA observations, although evolution of the spectral shape over this interval is not ruled out. The high X-ray luminosity, L_X~1e41 erg/sec, places SN 1995N in a small group of Type IIn supernovae with strong circumstellar interaction, and the evolving X-ray luminosity suggests that the circumstellar medium is distributed inhomogeneously.Comment: MNRAS accepted. 6 pages, 2 figures; uses mn.sty and psfi

The X-ray Spectrum of the Rapid Burster using the Chandra HETGS

We present observations of the Rapid Burster (RB, also known as MXB 1730-335) using the Chandra High Energy Transmission Grating Spectrometer. The average interval between type II (accretion) bursts was about 40 s. There was one type I (thermonuclear flash) burst and about 20 "mini-bursts" which are probably type II bursts whose peak flux is 10-40% of the average peak flux of the other type II bursts. The time averaged spectra of the type II bursts are well fit by a blackbody with a temperature of kT = 1.6 keV, a radius of 8.9 km for a distance of 8.6 kpc, and an interstellar column density of 1.7e22 per sq. cm. No narrow emission or absorption lines were clearly detected. The 3 sigma upper limits to the equivalent widths of any features are < 10 eV in the 1.1-7.0 keV band and as small as 1.5 eV near 1.7 keV. We suggest that Comptonization destroys absorption features such as the resonance line of Fe XXVI.Comment: 10 pages, 4 figures, accepted for publication in AJ (with minor changes and enhanced discussion of the instrument configuration

Ion beam sputter-deposited thin film coatings for protection of spacecraft polymers in low Earth orbit

Ion beam sputter-deposited thin films of Al2O3, SiO2, and a codeposited mixture of predominantly SiO2 with small amounts of a fluoropolymer were evaluated both in laboratory plasma ashing tests and in space on board shuttle flight STS-8 for effectiveness in preventing oxidation of polyimide Kapton. Measurements of mass loss and optical performance of coated and uncoated polyimide samples exposed to the low Earth orbital environment are presented. Optical techniques were used to measure loss rates of protective films exposed to atomic oxygen. Results of the analysis of the space flight exposed samples indicate that thin film metal oxide coatings are very effective in protecting the polyimide. Metal oxide coatings with a small amount of fluoropolymer codeposited have the additional benefit of great flexibility