Birth outcome in relation to licorice consumption during pregnancy.

A role for glucocorticoids is suspected in the etiology of low birth weight. The authors tested whether maternal consumption of glycyrrhizin (an inhibitor of cortisol metabolism) in licorice affects birth weight in humans. A sample of 1,049 Finnish women and their healthy singleton infants was studied in 1998. Glycyrrhizin intake was calculated from detailed questionnaires on licorice consumption. Glycyrrhizin exposure was grouped into three levels: low ( or =500 mg/week; n = 110). Birth weight and gestational age (from ultrasound measurements) were obtained from hospital records. Babies with heavy exposure to glycyrrhizin were not significantly lighter at birth, but they were significantly more likely to be born earlier: The odds ratio for being born before 38 weeks' gestation was 2.5 (95% confidence interval: 1.1, 5.5; p = 0.03). Although the effect of heavy glycyrrhizin intake on mean duration of gestation was small (2.52 days) when expressed as an effect on the mean, this shift to the left of the distribution of duration of gestation was sufficient to double the risk of being born before 38 weeks. The association remained in multivariate analyses. In conclusion, heavy glycyrrhizin exposure during pregnancy did not significantly affect birth weight or maternal blood pressure, but it was significantly associated with lower gestational age

Indoor Particulate Matter during HOMEChem: Concentrations, Size Distributions, and Exposures.

It is important to improve our understanding of exposure to particulate matter (PM) in residences because of associated health risks. The HOMEChem campaign was conducted to investigate indoor chemistry in a manufactured test house during prescribed everyday activities, such as cooking, cleaning, and opening doors and windows. This paper focuses on measured size distributions of PM (0.001-20 μm), along with estimated exposures and respiratory-tract deposition. Number concentrations were highest for sub-10 nm particles during cooking using a propane-fueled stovetop. During some cooking activities, calculated PM2.5 mass concentrations (assuming a density of 1 g cm-3) exceeded 250 μg m-3, and exposure during the postcooking decay phase exceeded that of the cooking period itself. The modeled PM respiratory deposition for an adult residing in the test house kitchen for 12 h varied from 7 μg on a day with no indoor activities to 68 μg during a simulated day (including breakfast, lunch, and dinner preparation interspersed by cleaning activities) and rose to 149 μg during a simulated Thanksgiving day

Land, history or modernization? Explaining ethnic fractionalization

Ethnic fractionalization (EF) is frequently used as an explanatory tool in models of economic development, civil war and public goods provision. However, if EF is endogenous to political and economic change, its utility for further research diminishes. This turns out not to be the case. This paper provides the first comprehensive model of EF as a dependent variable. It contributes new data on the founding date of the largest ethnic group in each state. It builds political and international variables into the analysis alongside historical and geoclimatic parameters. It extends previous work by testing models of politically relevant EF. In addition, this research interprets model results in light of competing theories of nationalism and political change. Results show that cross-national variation in EF is largely exogenous to modern politico-economic change. However, the data are inconclusive with respect to competing geoclimatic, historical institutional and modernist theories of ethnogenesis

Activation of sub-3 nm organic particles in the particle size magnifier using humid and dry conditions

The accurate measurement of aerosol particles and clusters smaller than 3 nm in diameter is crucial for the understanding of new particle formation processes. The particle counters used for measuring these particles are typically calibrated with metal or salt particles under dry conditions, which does not always represent the field conditions where these instruments are later used. In this study, we calibrated the All nano Condensation Nucleus Counter (nCNC), consisting of the PSM (Particle Size Magnifier) and a laminar flow butanol based CPC (Condensational Particle Counter), with well-defined biogenic oxidation products from beta-caryophyllene oxidation and compared it to a calibration with tungsten oxide under the same conditions. The organic particles were detected less efficiently than the inorganic ones. This resulted in a higher cut-off size for beta-caryophyllene oxidation products than for tungsten oxide. At the same PSM settings, the cut-off size for tungsten oxide was 1.2 nm and for beta-caryophyllene oxidation products 1.9 nm. However, repeating the calibration of the biogenic particles at 13% relative humidity at 31 degrees C, increased their detection efficiency in the PSM, increasing the cut-off diameter to 1.6 nm. Additionally, we present a comparison of the ion concentrations measured with the PSM and the NAIS (Neutral Cluster and Air Ion Spectrometer) during new particle formation experiments in the CLOUD (Cosmics Leaving Outdoors Droplets) chamber. In these experiments, we produced particles from different organic precursors, such as alpha-pinene, beta-caryophyllene and isoprene, as well as iodine. This way, we could determine the shift in cut-off diameter of the PSM for several different atmospherically relevant chemical compounds and compare it to the laboratory calibrations. We saw a diameter shift for the organic precursors of +0.3 nm in the PSM compared to the NAIS. These two approaches agreed well with each other and show that it is important to know the chemical composition of the measured particles to determine the exact size distribution using a supersaturation scanning method.Peer reviewe

Eurooppalaisessa SPRINTT-tutkimuksessa selvitetään gerastenian ehkäisyä liikunta- ja ravitsemusintervention avulla

Maailmanlaajuisesti >60-vuotiaiden osuus väestöstä kasvaa nopeasti, mikä asettaa haasteita terveydenhuoltopalveluille. Haurastuminen eli gerastenia on yleistä vanhimmilla ikäihmisillä ja se johtaa fyysisen toimintakyvyn heikkenemiseen, lisää kaatumisriskiä, sosiaalista syrjäytymistä, heikentää elämänlaatua, lisää avun sekä laitoshoidon tarvetta. Liikkumiskyvyn ylläpitäminen on tärkeää, koska siten voidaan katkaista haurastumiseen johtava kierre. Yhteiseurooppalainen SPRINTT-projekti pyrkii kaksi vuotta kestävässä, satunnaistetussa, kontrolloidussa, liikuntaan ja ravitsemukseen pohjautuvassa interventiotutkimuksessa ehkäisemään ja hidastamaan liikkumiseen liittyviä toiminnanvajeita ≥70-vuotiailla henkilöillä, joilla jo on gerastenian merkkejä. Tutkimuksessa rekrytoidaan noin 1500 osallistujaa yhdestätoista Euroopan maasta. Interventioryhmän tutkittavat saavat yksilöityä ravitsemusneuvontaa, käyvät heille järjestetyssä liikuntaryhmissä ja toteuttavat kotiharjoitteluohjelmaa. Verrokkiryhmälle järjestetään kerran kuussa luentoja terveyteen ja hyvinvointiin liittyvistä teemoista. Päätulosmuuttujana tutkimuksessa on liikkumiskyky, jota mitataan 400 metrin kävelytestillä. Muita tulosmuuttujia ovat esimerkiksi muutokset lihasmassassa ja- voimassa, kaatumiset, kognitio, terveyspalvelujen käyttö ja elämänlaatu. SPRINTT-tutkimuksen tulosten odotetaan tuottavan tietoa, joka auttaa kehittämään gerastenian hoitoa sekä ehkäisemään liikkumiskyvyn heikkenemistä gerasteniariskissä olevilla ikäihmisillä. Lisäksi tutkimuksen tavoitteena on kehittää yleisesti hyväksytty määritelmä gerastenialle

AUTOEVALUACIÓN DEL PROGRAMA DE MEDICINA VETERINARIA Y ZOOTECNIA CON FINES DE ACREDITACIÓN DE CALIDAD

Las Facultades de Medicina Veterinaria y Zootecnia y Agronomía se crearon en la ciudad de Montería como dependencias de la Universidad Nacional de Colombia según la Ley 103 del Congreso Nacional, de fecha 29 de Diciembre de 1962, pero dicha Ley no tuvo cumplimiento. Ante el anhelo frustrado de no contar con una Universidad seccional, pretendida con la Ley 103, el Gobierno Departamental dictó el Decreto 0319 de 1964 por el cual se le otorgó personería jurídica a la Universidad de Córdoba. En el año 1966 el Congreso de República expidió la Ley 37 por medio de la cual se crea la Universidad de Córdoba como una entidad autónoma y descentralizada que se acogía al Decreto-Ley 0277 de 1958 que regía para las universidades departamentales. Sólo hasta el año de 1970, mediante una sentencia de Estado, se enmienda el error y se le da el carácter nacional a la Institución por haber sido creada mediante Ley de la República

Homogenous nucleation of sulfuric acid and water at close to atmospherically relevant conditions

Abstract. In this study the homogeneous nucleation rates in the system of sulfuric acid and water were measured by using a flow tube technique. The goal was to directly compare particle formation rates obtained from atmospheric measurements with nucleation rates of freshly nucleated particles measured with particle size magnifier (PSM) which has detection efficiency of unity for particles having mobility diameter of 1.5 nm. The gas phase sulfuric acid concentration in this study was measured with the chemical ionization mass spectrometer (CIMS), commonly used in field measurements. The wall losses of sulfuric acid were estimated from measured concentration profiles along the flow tube. The initial concentrations of sulfuric acid estimated from loss measurements ranged from 108 to 3 × 109 molecules cm−3. The nucleation rates obtained in this study cover about three orders of magnitude from 10−1 to 102 cm−3 s−1 for commercial ultrafine condensation particle counter (UCPC) TSI model 3025A and from 101 to 104 cm−3 s−1 for PSM. The nucleation rates and the slopes (dlnJ/dln [H2SO4]) show satisfactory agreement when compared to empirical kinetic and activation models and the latest atmospheric nucleation data. To the best of our knowledge, this is the first experimental work providing temperature dependent nucleation rate measurements using a high efficiency particle counter with a cut-off-size of 1.5 nm together with direct measurements of gas phase sulfuric acid concentration. </jats:p

Reduced particle composition dependence in condensation particle counters

Modern condensation particle counters (CPCs) are indispensable instruments for studies of aerosols in all measurement environments. Relying on heterogeneous nucleation as the basic principle, the composition dependence of particle activation is a source of profound uncertainty for the accurate assessment of new particle formation (NPF) events. While development efforts successfully pushed down minimum detectable particle sizes in recent years, composition-dependent counting efficiencies have remained to be a persisting issue in aerosol research. Addressing this pressing problem, we present calibrations of a newly developed CPC, the Airmodus A30 (Airmodus Ltd., Helsinki, Finland), that uses non-hazardous propylene glycol as working fluid. Our results conclusively demonstrate that composition-dependent particle detection can be reduced to the brink of disappearance by choice of the working fluid and corresponding high supersaturation. Counting efficiencies were determined for a set of size-selected and chemically diverse seed particles, and the measured 50 % cutoff diameters were compared to previous studies. Using computational fluid dynamics simulations, we show that the composition dependence appears to decrease with increasing saturation ratios achieved inside the CPC. Hence, our study assists in the development of future CPCs and elucidates a potential mechanism to reduce measurement uncertainties arising from composition-dependent counting efficiencies.</p