Uterine adenocarcinoma with abdominal metastases in an ovariohysterectomised female cat

An adenocarcinoma of the uterine stump with abdominal metastases is described in a 12-year-old incompletely ovariohysterectomised female Domestic Short Haired (DSH) cat. At the time of presentation the adenocarcinoma had metastasised to the right peri-renal lymph node, the abdominal aorta, and the right ureter, resulting in the formation of a large cystic structure. This had compressed and displaced surrounding structures including the abdominal vena cava and the right kidney, and formed multiple adhesions to the body wall and adjacent abdominal structures. Metastatic extension to the aorta had resulted in its regression into a 2mm diameter non-pulsatile vessel

Instantons on ALE spaces and Super Liouville Conformal Field Theories

We provide evidence that the conformal blocks of N=1 super Liouville conformal field theory are described in terms of the SU(2) Nekrasov partition function on the ALE space O_{P^1}(-2).Comment: 10 page

Synthesis of Mesoporous Gadolinium Doped Ceria - Platinum Composite

published_or_final_versio

Synthesis of Pt-OMG mesoporous composite via nanocasting and chemical vapor infiltration

published_or_final_versio

Surface Operators in N=2 4d Gauge Theories

N=2 four dimensional gauge theories admit interesting half BPS surface operators preserving a (2,2) two dimensional SUSY algebra. Typical examples are (2,2) 2d sigma models with a flavor symmetry which is coupled to the 4d gauge fields. Interesting features of such 2d sigma models, such as (twisted) chiral rings, and the tt* geometry, can be carried over to the surface operators, and are affected in surprising ways by the coupling to 4d degrees of freedom. We will describe in detail a relation between the parameter space of twisted couplings of the surface operator and the Seiberg-Witten geometry of the bulk theory. We will discuss a similar result about the tt* geometry of the surface operator. We will predict the existence and general features of a wall-crossing formula for BPS particles bound to the surface operator.Comment: 25 pages, 4 figure

The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin.

This study was undertaken to determine the roles of individual alpha/beta 1 integrin heterodimers in promoting cellular interactions with the different attachment-promoting domains of laminin (LN). To do this, antibodies to the integrin beta 1 subunit or to specific integrin alpha subunits were tested for effects on cell attachment to LN, to elastase fragments E1-4 and E1, derived from the short arms and core of LN's cruciform structure, and to fragment E8 derived from the long arm of this structure. The human JAR choriocarcinoma cells used in this study attached to LN and to fragments E1 and E8. Attachment to E1-4 required a much higher substrate coating concentration, suggesting that it is a poor substrate for JAR cell attachment. The ability of cells to attach to different LN domains suggested the presence of more than one LN receptor. These multiple LN receptors were shown to be beta 1 integrin heterodimers because antibodies to the integrin beta 1 subunit inhibited attachment of JAR cells to LN and its three fragments. To identify the individual integrin alpha/beta 1 heterodimers that mediate interactions with these LN domains, mAbs specific for individual beta 1 heterodimers in human cells were used to study JAR cell interactions with LN and its fragments. An anti-alpha 6/beta 1-specific mAb, GoH3, virtually eliminated cell attachment to E8 and partially inhibited attachment to E1 and intact LN. Thus the major alpha 6/beta 1 attachment domain is present in fragment E8. An alpha 1/beta 1-specific mAb (S2G3) strongly inhibited cell attachment to collagen IV and partially inhibited JAR attachment to LN fragment E1. Thus, the alpha 1/beta 1 heterodimer is a dual receptor for collagen IV and LN, interacting with LN at a site in fragment E1. In combination, the anti-alpha 1- and anti-alpha 6-specific antibodies completely inhibited JAR cell attachment to LN and fragment E1. Thus, the alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers each function as LN receptors and act together to mediate the interactions of human JAR choriocarcinoma cells with LN

Some comments on spacelike minimal surfaces with null polygonal boundaries in AdSmAdS_m

We discuss some geometrical issues related to spacelike minimal surfaces in $AdS_m$ with null polygonal boundaries at conformal infinity. In particular for $AdS_4$, two holomorphic input functions for the Pohlmeyer reduced system are identified. This system contains two coupled differential equations for two functions $\alpha (z,\bar z)$ and $\beta (z,\bar z)$, related to curvature and torsion of the surface. Furthermore, we conjecture that, for a polynomial choice of the two holomorphic functions, the relative positions of their zeros encode the conformal invariant data of the boundary null $2n$-gon.Comment: 13 pages, a note and references added, version to appear in JHE

Can Wheat Germ Have a Beneficial Effect on Human Health? A Study Protocol for a Randomised Crossover Controlled Trial to Evaluate its Health Effects

INTRODUCTION: Cardiovascular diseases (CVD) are the leading cause of mortality worldwide and diet is an important contributor to CVD risk. Thus, several food derivatives are being investigated for their beneficial impact on reducing cardiometabolic risk factors, either in risk groups or in healthy population as a preventive measure. Wheat germ is a food by-product with high nutritional value, especially as a concentrated source of dietary fibre and essential fatty acids, but its incorporation into the diet has been rare up to now. Previous studies do not clarify the hypothesised potential causal relationship between the consumption of wheat germ and benefits for human health. METHODS AND ANALYSIS: We are conducting a randomised, double-blinded, crossover, placebo-controlled clinical trial designed to assess the physiological effects of daily consumption of wheat germ-enriched bread (containing 6 g of wheat germ) compared with non-enriched bread, over a 4-week period with a 15-week follow-up, in a healthy human population. A total of 55 participants (healthy volunteers, aged 18-60) have been recruited from the Porto metropolitan area in northern Portugal. Our aim is to evaluate the health effects of wheat germ on blood cholesterol and triglycerides, postprandial glycaemic response, gastrointestinal function and discomfort, and changes in intestinal microbiota and insulin resistance as secondary outcomes. The study follows the best practices for evaluating health claims in food according to the European Food Safety Authority (EFSA) scientific opinion, namely random allocation, double blinding, reporting methods to measure and maximise compliance, and validated outcomes with beneficial physiological effects as recommended by EFSA. ETHICS AND DISSEMINATION: The study has been approved by the Health Ethics Committee of São João Hospital Centre (156-15) and the Ethics Committee of Faculty of Medicine of the University of Porto (PCEDCSS-FMUP07/2015). Results will be disseminated through peer-reviewed publications and presentations at international scientific meetings.info:eu-repo/semantics/publishedVersio

Surface Operator, Bubbling Calabi-Yau and AGT Relation

Surface operators in N=2 four-dimensional gauge theories are interesting half-BPS objects. These operators inherit the connection of gauge theory with the Liouville conformal field theory, which was discovered by Alday, Gaiotto and Tachikawa. Moreover it has been proposed that toric branes in the A-model topological strings lead to surface operators via the geometric engineering. We analyze the surface operators by making good use of topological string theory. Starting from this point of view, we propose that the wave-function behavior of the topological open string amplitudes geometrically engineers the surface operator partition functions and the Gaiotto curves of corresponding gauge theories. We then study a peculiar feature that the surface operator corresponds to the insertion of the degenerate fields in the conformal field theory side. We show that this aspect can be realized as the geometric transition in topological string theory, and the insertion of a surface operator leads to the bubbling of the toric Calabi-Yau geometry.Comment: 36 pages, 14 figures. v2: minor changes and typos correcte