Neurofibrome de l’avant bras: à propos d’un cas

Les tumeurs des nerfs périphériques sont rares et mal connues. Le diagnostic en est rarement fait avant  l'intervention. Le traitement chirurgical est difficile, et risque d'entrainer des dégâts nerveux irréversibles s'il est mal conduit. Nous rapportons un cas de neurofibrome de l'avant bras dont la symptomatologie est souvent discrète associé à des taches café au lait sur la peau. De ce fait, l'imagerie et l'examen anatomopathologique ont une place importante dans la prise en charge de ces tumeurs.Key words: Neurofibromes, taches café au lait, imagerie, chirurgie, anatomie pathologi

A Mobile Application with Augmented Reality to Enhance Sinhala Learning Experience for Children

Augmented Reality has gone from science fiction dream to possible emerging technology in the modern world. This futuristic technology has the ability to blend the real world with digital world. This paper presents an Augmented Reality based mobile solution for children to enhance their Sinhala alphabet learning experience. With this tool, children can interactively learn letters, pronunciation and usage of letters in real world scenarios. Generally, teaching preschool children could be difficult since they only focus on an activity for a short period of time. Therefore this solution mainly focuses on adding fun and entertainment while addressing cognitive skills of the children. This application adds totally new learning experience for its users. A survey done with pre-school children and teachers proved that using Augmented Reality based solution with latest technologies are very helpful for learning things and teaching things efficiently. Most students requested to use the Augmented Reality application repeatedly. Teachers showed high level of enthusiasm and over 85% of the respondents gave extremely positive feedbac

Thermoplasmonic ssDNA Dynamic Release from Gold Nanoparticles Examined with Advanced Fluorescence Microscopy

Plasmon excitation of spherical gold nanoparticles carrying a fluorescent labeled 30 bp dsDNA cargo, with one chain covalently attached through two S–Au bonds to the surface, results in release of the complementary strand as ssDNA that can be examined in situ using high-resolution fluorescence microscopy. The release is dependent on the total energy delivered, but not the rate of delivery, an important property for plasmonic applications in medicine, sensors, and plasmon-induced PCR

Kernel Architecture of the Genetic Circuitry of the Arabidopsis Circadian System

A wide range of organisms features molecular machines, circadian clocks, which generate endogenous oscillations with ~24 h periodicity and thereby synchronize biological processes to diurnal environmental fluctuations. Recently, it has become clear that plants harbor more complex gene regulatory circuits within the core circadian clocks than other organisms, inspiring a fundamental question: are all these regulatory interactions between clock genes equally crucial for the establishment and maintenance of circadian rhythms? Our mechanistic simulation for Arabidopsis thaliana demonstrates that at least half of the total regulatory interactions must be present to express the circadian molecular profiles observed in wild-type plants. A set of those essential interactions is called herein a kernel of the circadian system. The kernel structure unbiasedly reveals four interlocked negative feedback loops contributing to circadian rhythms, and three feedback loops among them drive the autonomous oscillation itself. Strikingly, the kernel structure, as well as the whole clock circuitry, is overwhelmingly composed of inhibitory, rather than activating, interactions between genes. We found that this tendency underlies plant circadian molecular profiles which often exhibit sharply-shaped, cuspidate waveforms. Through the generation of these cuspidate profiles, inhibitory interactions may facilitate the global coordination of temporally-distant clock events that are markedly peaked at very specific times of day. Our systematic approach resulting in experimentally-testable predictions provides insights into a design principle of biological clockwork, with implications for synthetic biology.Comment: Supplementary material is available at the journal websit

A Systematic Review of Research on Guided Access Cavity Preparation Endodontic Treatment: Dentin Preservation Perspectives

Anna Muryani,1,2 Dudi Aripin,2 Hendra Dian Adhita Dharsono,2 Zainul Ahmad Rajion,3 Satrio Wicaksono4 1Doctoral Programme Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia; 2Conservative Dentistry Department Faculty of Dentistry, Universitas Padjadjaran, Bandung, West Java, Indonesia; 3Department Oral Maxillofacial Surgery and Oral Diagnosis Kulliyyah of Dentistry International Islamic University Malaysia, Kuantan, Malaysia; 4Faculty of Mechanical and Aerospace Engineering, Institut Teknologi Bandung, Bandung, West Java, IndonesiaCorrespondence: Anna Muryani, Gedung Pamitran Unpad, lantai 4 Wing Utara Jl. Prof. Eyckman No. 38 Bandung, Faculty of Medicine, Universitas Padjadjaran, West Java, Indonesia, 40161, Tel +62 896 1997 2132, Email [email protected]: Guided access cavity preparation (GACP) is an endodontic procedure utilizing stents, guide sleeves, or dynamic guides to facilitate the proper formation of access cavities. This paper aims to evaluate the significance of research on guided access cavity preparation in endodontic treatment concerning dentin preservation. In the context of dentin preservation, this paper provides a thorough scoping review of a variety of methodologies for evaluating the accuracy of guided access cavity preparation.Materials and Methods: Article searches were conducted using Tthe keywords ”Guide Access Cavity Preparation” AND “Static Guide OR 3D Printing Template” AND ”Dynamic Guide through digital databases including PubMed, Scopus, Cochrane Library, Science Direct, and Google Scholar. Research articles published in English within the past five years (2019-2024) and in accordance with the PCC (Population, Concept, and Context) framework were also included in the study. Articles from the meta-analysis or systematic review study type, those that were not accessible in full text or in a paid format, and those that did not assess the use of guided endodontics in endodontic surgery were excluded. This scoping review adheres to the Preferred Reporting Items for Systematic Reviews without Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) criteria.Results: A total of 12 articles were reviewed, encompassing various locations, designs, type, and samples, which demonstrated the use of guided access cavity preparation has significant clinical applications and can provide accurate results in endodontic therapy.Conclusion: Article searches were conducted using the keywords “Guide Access Cavity Preparation” AND ‘Static Guide OR 3D Printing Template’ AND” Dynamic Guide through digital databases including PubMed, Scopus, Cochrane Library, Science Direct, and Google Scholar. Research articles published in English within the past five years (2019– 2024) and in accordance with the PCC (Population, Concept, and Context) framework were also included in the study. Articles from the meta-analysis or systematic review study type, those that were not accessible in full text or in a paid format, and those that did not assess the use of guided endodontics in endodontic surgery were excluded. This scoping review adheres to the Preferred Reporting Items for Systematic Reviews without Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) criteria. Studies show that advanced technologies in guided access cavity preparation endodontic treatment can improve dentin preservation, improve accuracy and predictability, particularly for root canal anomalies and difficult teeth, but clinicians must consider limitations and clinical applications. Clinicians must evaluate the limitations and clinical applications of guided endodontic access prior to its implementation.Keywords: guided endodontic access, GEA, guided access cavity preparation, GACP, static guided endodontic access, SGEA, dynamic guide endodontic access, DGEA, preservation denti

A study of 4D printing and functionally graded additive manufacturing

Purpose: The purpose of this paper is to extend existing knowledge of 4D printing, in line with Khoo et al. (2015) who defined the production of 4D printing using a single material, and 4D printing of multiple materials. It is proposed that 4D printing can be achieved through the use of functionally graded materials (FGMs) that involve gradational mixing of materials and are produced using an additive manufacturing (AM) technique to achieve a single component. Design/methodology/approach: The latest state-of-the-art literature was extensively reviewed, covering aspects of materials, processes, computer-aided design (CAD), applications and made recommendations for future work. Findings: This paper clarifies that functionally graded additive manufacturing (FGAM) is defined as a single AM process that includes the gradational mixing of materials to fabricate freeform geometries with variable properties within one component. The paper also covers aspects of materials, processes, CAD, applications and makes recommendations for future work. Research limitations/implications: This paper examines the relationship between FGAM and 4D printing and defines FGAM as a single AM process involving gradational mixing of materials to fabricate freeform geometries with variable properties within one component. FGAM requires better computational tools for modelling, simulation and fabrication because current CAD systems are incapable of supporting the FGAM workflow. Practical implications: It is also identified that other factors, such as strength, type of materials, etc., must be taken into account when selecting an appropriate process for FGAM. More research needs to be conducted on improving the performance of FGAM processes through extensive characterisation of FGMs to generate a comprehensive database and to develop a predictive model for proper process control. It is expected that future work will focus on both material characterisation as well as seamless FGAM control processes. Originality/value: This paper examines the relationship between FGAM and 4D printing and defines FGAM as a single AM process that includes gradational mixing of materials to fabricate freeform geometries with variable properties within one component.1531470,6031,383Q1Q3SCI

Stress Analysis on Mesiolingual Cavity of Endodontically Treated Molar Restored Using Bidirectional Fiber-Reinforced Composite (Wallpapering Technique)

Harnia Neri,1 Dudi Aripin,1 Anna Muryani,1 Hendra Dian Adhita Dharsono,1 Yolanda Yolanda,1 Andi Isra Mahyuddin2 1Department of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia; 2Faculty of Mechanical and Aerospace Engineering, Bandung Institute of Technology, Bandung, IndonesiaCorrespondence: Anna Muryani; Harnia Neri, Department of Conservative Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Jl. Sekeloa Selatan no. 1, Bandung, 40123, Indonesia, Tel +62 896 19972132, Email [email protected]; [email protected]: Endodontically treated teeth (ETT) undergo extensive structure change and experience high stress during biomechanical function. Stress distribution is influenced by the restoration material and the type of bond between material and tooth structure. The selection of materials that can distribute stress will affect the resistance and retention of ETT to mastication forces, thus biomechanical functions were achieved. Composite has mechanical properties similar to dentin, it can transmit and distribute stresses throughout the tooth surface. The disadvantage of composites in large cavities is their lack of toughness. The addition of fiber to composites can increase their toughness.Purpose: This research is to determine the stress distribution of a fiber-reinforced composite made of polyethylene and e-glass on the mesiolingual cavity of ETT.Materials and Methods: A three-dimensional model of the mandibular molar was prepared for cavity preparation and the formation of restorations using SolidWorks 2021. The models were analyzed with Abaqus 2020 to determine stress concentrations after given vertical and oblique loading.Results: The maximum and minimum principal stress data were obtained to assess material resistance and interfacial damage criterion. Polyethylene fiber shows a more homogeneous stress distribution because the modulus of elasticity is close to the dentin and has a thickness that can reduce the volume of the composite. The E-glass shows the stress concentration on the circumferential fiber and cavity floor.Conclusion: The stress distribution of fiber-reinforced composite on the buccolingual cavity of ETT using the finite element method did not show structural failure in the polyethylene group because the maximum and minimum principal stresses were lower than the strength of the material. Interfacial bond failure occurs at the enamel portion. The maximum and minimum principal values of e-glass indicate structural failure in the circumferential fiber and the base fiber because the stress exceeds the strength of the material. Interfacial bond failure occurred on the circumferential and the cavity floor.Keywords: stress distribution, bidirectional polyethylene fiber, bidirectional e-glass fiber, finite element method, wallpapering techniqu

Current Cytogenetic Abnormalities in Acute Myeloid Leukemia

Cytogenetic abnormalities are frequently reported in the literature describing the presence of chromosomal rearrangements in important cases of acute myeloid leukemia (AML); the rate can reach 50–60% of cases of AML. Cytogenetic abnormalities represent an important prognosis factor, their analysis is crucial for AML; cytogenetic study permits to classify prognostic groups and indicate the treatment strategy and helps to improve the outcome of these patients and to increase their chances of cure. Hundreds of uncommon chromosomal aberrations from AML exist. This chapter summarizes chromosomal abnormalities that are common and classifies AML according to the World Health Organization (WHO) classifications from 2008 to 2016; we will discuss briefly gene mutations detected in normal karyotype (NK) AML by cutting-edge next-generation sequencing technology, like FLT3-ITD, nucleophosmin (NPM1), CCAAT/enhancer-binding protein alpha (CEBPA), and other additional mutations