U.S. HOUSEHOLD CONSUMPTION OF FRESH FRUITS

This study uses the 1987-88 U.S. Department of Agriculture Nationwide Food Consumption Survey data to analyze the impacts of income, prices, and selected socioeconomic characteristics on household consumption of fresh fruits. Results suggest that fresh fruits are considered economic necessities, with own prices significantly influencing consumption. Cross-price effects are generally weak and insignificant, but the number of adults in the age group 18-64 is an important determinant of household consumption of fresh fruits. While nutrition information and household savings have significant, positive influences on most fresh fruit consumption, the presence of a working wife has a significant and negative influence.Food Consumption/Nutrition/Food Safety,

The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease

The dramatic recent rise in the incidence of allergic or autoimmune inflammatory diseases in the West has been proposed to reflect the lack of appropriate priming of the immune response by infectious agents such as parasitic worms during childhood. Consistent with this, there is increasing evidence supporting an inverse relationship between worm infection and T helper type 1/17 (Th1/17)-based inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, type 1 diabetes and multiple sclerosis. Perhaps more surprisingly, given that such worms often induce strong Th2-type immune responses, there also appears to be an inverse correlation between parasite load and atopy. These findings therefore suggest that the co-evolution of helminths with hosts, which has resulted in the ability of worms to modulate inflammatory responses to promote parasite survival, has also produced the benefit of protecting the host from pathological lesions arising from aggressive proinflammatory responses to infection or, indeed, aberrant inflammatory responses underlying autoimmune and allergic disorders. By focusing upon the properties of the filarial nematode-derived immunomodulatory molecule, ES-62, in this review we shall discuss the potential of exploiting the immunomodulatory products of parasitic worms to identify and develop novel therapeutics for inflammation

Tidal modulation and back-propagating fronts in slow slip events simulated with a velocity-weakening to velocity-strengthening friction law

We examine tidal modulation and back-propagating fronts in simulated slow slip events using a rate and state friction law that is steady state velocity weakening at low slip rates and velocity strengthening at high slip rates. Tidal forcing causes a quasi-sinusoidal modulation of the slip rate during the events, with the maximum moment rate occurring close to or slightly after the maximum applied stress. The amplitude of modulation scales linearly with the tidal load and increases as the tidal period increases relative to the timescale for state evolution. If we choose parameters so that the model matches the observed tidal modulation of slip in Cascadia, it can reproduce only a subset of the stress drops inferred from observations and only in a limited portion of parameter space. The tidal forcing also causes back-propagating fronts to form and move back through the region that has already ruptured. The stress drop that drives these back-propagating fronts sometimes comes from the tidal load and sometimes from a stress recovery that occurs behind the front in tidal and non-tidal simulations. We investigate the slip and propagation rates in the back-propagating fronts and compare them with observations. The modeled fronts propagate too slowly to be good representations of the fronts inferred from tremor observations. For the simulated fronts to propagate at the observed speeds, the stress drops driving them would have to be more than 70 % of the stress drop driving the forward-propagating front

Human Thiel-Embalmed Cadaveric Aortic Model with Perfusion for Endovascular Intervention Training and Medical Device Evaluation

Purpose: The purpose of this investigation was to evaluate human Thiel-embalmed cadavers with the addition of extracorporeal driven ante-grade pulsatile flow in the aorta as a model for simulation training in interventional techniques and endovascular device testing.Materials and Methods: Three human cadavers embalmed according to the method of Thiel were selected. Extracorporeal pulsatile ante-grade flow of 2.5 L per min was delivered directly into the aorta of the cadavers via a surgically placed connection. During perfusion, aortic pressure and temperature were recorded and optimized for physiologically similar parameters. Pre- and post-procedure CT imaging was conducted to plan and follow up thoracic and abdominal endovascular aortic repair as it would be in a clinical scenario. Thoracic endovascular aortic repair (TEVAR) and endovascular abdominal repair (EVAR) procedures were conducted in simulation of a clinical case, under fluoroscopic guidance with a multidisciplinary team present.Results: The Thiel cadaveric aortic perfusion model provided pulsatile ante-grade flow, with pressure and temperature, sufficient to conduct a realistic simulation of TEVAR and EVAR procedures. Fluoroscopic imaging provided guidance during the intervention. Pre- and post-procedure CT imaging facilitated planning and follow-up evaluation of the procedure.Conclusion: The human Thiel-embalmed cadavers with the addition of extracorporeal flow within the aorta offer an anatomically appropriate, physiologically similar robust model to simulate aortic endovascular procedures, with potential applications in interventional radiology training and medical device testing as a pre-clinical model

Active children through incentive vouchers – evaluation (ACTIVE): a mixed-method feasibility study

BackgroundAdolescents face many barriers to physical activity, demonstrated by the decline in physical activity levels in teenage populations. This study aimed to assess the feasibility of overcoming such barriers via the implementation of an activity-promoting voucher scheme to teenagers in deprived areas.MethodsAll Year 9 pupils (n = 115; 13.3 ± 0.48 years; 51 % boys) from one secondary school in Wales (UK) participated. Participants received £25 of activity vouchers every month for six months for physical activity or sporting equipment. Focus groups (n = 7), with 43 pupils, and qualitative interviews with teachers (n = 2) were conducted to assess feasibility, in addition to a process evaluation utilising the RE-AIM framework. Quantitative outcomes at baseline, five months (during intervention) and twelve months (follow-up) included: physical activity (accelerometer), aerobic fitness (12 min Cooper run) and self-reported activity (PAQ-A). Motivation to exercise (BREQ-2) was measured three months post-baseline and at follow-up.ResultsQualitative findings showed that vouchers encouraged friends to socialise through activity, provided opportunities to access local activities that pupils normally could not afford, and engaged both those interested and disinterested in physical education. Improvements in weekend moderate-to-vigorous physical activity and reductions in sedentary behaviour were observed in both sexes. Boys’ fitness significantly improved during the voucher scheme. ‘Non-active’ pupils (those not meeting recommended guidelines of 60 mins∙day−1) and those with higher motivation to exercise had higher voucher use.ConclusionsAdolescents, teachers and activity providers supported the voucher scheme and felt the vouchers enabled deprived adolescents to access more physical activity opportunities. Voucher usage was associated with improved attitudes to physical activity, increased socialisation with friends and improved fitness and physical activity; presenting interesting avenues for further exploration in a larger intervention trial

A cohort study to identify and evaluate concussion risk factors across multiple injury settings: findings from the CARE Consortium

BACKGROUND: Concussion, or mild traumatic brain injury, is a major public health concern affecting 42 million individuals globally each year. However, little is known regarding concussion risk factors across all concussion settings as most concussion research has focused on only sport-related or military-related concussive injuries. METHODS: The current study is part of the Concussion, Assessment, Research, and Education (CARE) Consortium, a multi-site investigation on the natural history of concussion. Cadets at three participating service academies completed annual baseline assessments, which included demographics, medical history, and concussion history, along with the Sport Concussion Assessment Tool (SCAT) symptom checklist and Brief Symptom Inventory (BSI-18). Clinical and research staff recorded the date and injury setting at time of concussion. Generalized mixed models estimated concussion risk with service academy as a random effect. Since concussion was a rare event, the odds ratios were assumed to approximate relative risk. RESULTS: Beginning in 2014, 10,604 (n = 2421, 22.83% female) cadets enrolled over 3 years. A total of 738 (6.96%) cadets experienced a concussion, 301 (2.84%) concussed cadets were female. Female sex and previous concussion were the most consistent estimators of concussion risk across all concussion settings. Compared to males, females had 2.02 (95% CI: 1.70-2.40) times the risk of a concussion regardless of injury setting, and greater relative risk when the concussion occurred during sport (Odds Ratio (OR): 1.38 95% CI: 1.07-1.78). Previous concussion was associated with 1.98 (95% CI: 1.65-2.37) times increased risk for any incident concussion, and the magnitude was relatively stable across all concussion settings (OR: 1.73 to 2.01). Freshman status was also associated with increased overall concussion risk, but was driven by increased risk for academy training-related concussions (OR: 8.17 95% CI: 5.87-11.37). Medical history of headaches in the past 3 months, diagnosed ADD/ADHD, and BSI-18 Somatization symptoms increased overall concussion risk. CONCLUSIONS: Various demographic and medical history factors are associated with increased concussion risk. While certain factors (e.g. sex and previous concussion) are consistently associated with increased concussion risk, regardless of concussion injury setting, other factors significantly influence concussion risk within specific injury settings. Further research is required to determine whether these risk factors may aid in concussion risk reduction or prevention

Controls on mid‐ocean ridge normal fault seismicity across spreading rates from rate‐and‐state friction models

Author Posting. © American Geophysical Union., 2018. This article is posted here by permission of American Geophysical Union.for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Solid Earth 123 (2018): 6719-6733, doi:10.1029/2018JB015545.Recent seismic and geodetic observations have led to a growing realization that a significant amount of fault slip at plate boundaries occurs aseismically and that the amount of aseismic slip varies across tectonic settings. Seismic moment release rates measured along the fast‐spreading East Pacific Rise suggest that the majority of fault slip occurs aseismically. By contrast, at the slow‐spreading Mid‐Atlantic Ridge seismic slip may represent up to 60% of total fault displacement. In this study, we use rate‐and‐state friction models to quantify the seismic coupling coefficient, defined as the fraction of total fault slip that occurs seismically, on mid‐ocean ridge normal faults and investigate controls on fault behavior that might produce variations in coupling observed at oceanic spreading centers. We find that the seismic coupling coefficient scales with the ratio of the downdip width of the seismogenic area (W) to the critical earthquake nucleation size (h*). At mid‐ocean ridges, W is expected to increase with decreasing spreading rate. Thus, the relationship between seismic coupling and W/h* predicted from our models explains the first‐order variations in seismic coupling coefficient as a function of spreading rate.National Science Foundation (NSF) Grant Numbers: EAR‐10‐10432, OCE‐10‐61203; NSF | GEO | Division of Earth Sciences (EAR); NSF | GEO | Division of Ocean Sciences (OCE)2019-02-1

Nothing Lasts Forever: Environmental Discourses on the Collapse of Past Societies

The study of the collapse of past societies raises many questions for the theory and practice of archaeology. Interest in collapse extends as well into the natural sciences and environmental and sustainability policy. Despite a range of approaches to collapse, the predominant paradigm is environmental collapse, which I argue obscures recognition of the dynamic role of social processes that lie at the heart of human communities. These environmental discourses, together with confusion over terminology and the concepts of collapse, have created widespread aporia about collapse and resulted in the creation of mixed messages about complex historical and social processes

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome

Sjögren’s syndrome is a common autoimmune disease (~0.7% of European Americans) typically presenting as keratoconjunctivitis sicca and xerostomia. In addition to strong association within the HLA region at 6p21 (Pmeta=7.65×10−114), we establish associations with IRF5-TNPO3 (Pmeta=2.73×10−19), STAT4 (Pmeta=6.80×10−15), IL12A (Pmeta =1.17×10−10), FAM167A-BLK (Pmeta=4.97×10−10), DDX6-CXCR5 (Pmeta=1.10×10−8), and TNIP1 (Pmeta=3.30×10−8). Suggestive associations with Pmeta<5×10−5 were observed with 29 regions including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2, and PHIP amongst others. These results highlight the importance of genes involved in both innate and adaptive immunity in Sjögren’s syndrome

Software process simulation-at a crossroads?

Software Process Simulation (SPS) has been evolving over the past two decades after being introduced to the software engineering community in the 1980s. At that time the SPS technology attracted a great deal of interest from both academics and practitioners in the software process community – even to the extent of being one of the recommended techniques for achieving the quantitative modeling KPA for CMMI Level 4. However, in recent years, the growth of SPS seems to have slowed along with the number of reported applications in industry. This article summarizes the special panel during ICSSP 2012 whose goal was to assess whether this technology remains applicable to today’s software engineering projects and challenges and point out the most beneficial opportunities for future research and industry application.Peer reviewe