Concentration and synthesis of phosphoribosylpyrophosphate in erythrocytes from normal, hyperuricemic, and gouty subjects.

Phosphoribosylpyrophosphate (PRPP) synthetase activity and the intracellular concentration of PRPP were assayed in erythrocytes from patients with primary hyperuricemia and primary metabolic gout. Sensitivity of the enzyme to feed-back inhibition by adenosine diphosphate (ADP), guanosine diphosphate (GDP), and 2,3-diphosphoglycerate (2,3-DPG) was determined. All patients with gout and four of ten patients with hyperuricemia were taking allopurinol during the study. Mean PRPP synthetase activity in erythrocytes from hyperuricemic and gouty patients was similar to that in normal subjects, and feedback inhibition by ADP, GDP, and 2,3-DPG was intact. The concentration of PRPP in erythrocytes was higher in normal females than in normal males, higher in normal subjects than in gouty patients, and lower in hyperuricemic patients taking allopurinol than in those hyperuricemic patients not taking this drug. The difference in intracellular levels of PRPP in erythrocytes in gout versus hyperuricemic patients was not significant. The significance of these findings is discussed in relation to the regulation of PRPP synthetase and in the important regulatory role of PRPP in purine metabolism. © 1971

Checking the transverse Ward-Takahashi relation at one loop order in 4-dimensions

Some time ago Takahashi derived so called {\it transverse} relations relating Green's functions of different orders to complement the well-known Ward-Green-Takahashi identities of gauge theories by considering wedge rather than inner products. These transverse relations have the potential to determine the full fermion-boson vertex in terms of the renormalization functions of the fermion propagator. He & Yu have given an indicative proof at one-loop level in 4-dimensions. However, their construct involves the 4th rank Levi-Civita tensor defined only unambiguously in 4-dimensions exactly where the loop integrals diverge. Consequently, here we explicitly check the proposed transverse Ward-Takahashi relation holds at one loop order in $d$-dimensions, with $d=4+\epsilon$.Comment: 20 pages, 3 figures This version corrects and clarifies the previous result. This version has been submitted for publicatio

Proximity Full-Text Search with a Response Time Guarantee by Means of Additional Indexes

Full-text search engines are important tools for information retrieval. Term proximity is an important factor in relevance score measurement. In a proximity full-text search, we assume that a relevant document contains query terms near each other, especially if the query terms are frequently occurring words. A methodology for high-performance full-text query execution is discussed. We build additional indexes to achieve better efficiency. For a word that occurs in the text, we include in the indexes some information about nearby words. What types of additional indexes do we use? How do we use them? These questions are discussed in this work. We present the results of experiments showing that the average time of search query execution is 44-45 times less than that required when using ordinary inverted indexes. This is a pre-print of a contribution "Veretennikov A.B. Proximity Full-Text Search with a Response Time Guarantee by Means of Additional Indexes" published in "Arai K., Kapoor S., Bhatia R. (eds) Intelligent Systems and Applications. IntelliSys 2018. Advances in Intelligent Systems and Computing, vol 868" published by Springer, Cham. The final authenticated version is available online at: https://doi.org/10.1007/978-3-030-01054-6_66. The work was supported by Act 211 Government of the Russian Federation, contract no 02.A03.21.0006.Comment: Alexander B. Veretennikov. Chair of Calculation Mathematics and Computer Science, INSM. Ural Federal Universit

Outer zone electrons

Spatial and temporal behavior of high energy trapped electrons in outer zone of magnetospher

Operation of graphene quantum Hall resistance standard in a cryogen-free table-top system

We demonstrate quantum Hall resistance measurements with metrological accuracy in a small cryogen-free system operating at a temperature of around 3.8K and magnetic fields below 5T. Operating this system requires little experimental knowledge or laboratory infrastructure, thereby greatly advancing the proliferation of primary quantum standards for precision electrical metrology. This significant advance in technology has come about as a result of the unique properties of epitaxial graphene on SiC.Comment: 15 pages, 9 figure

Projections, Pseudo-Stopping Times and the Immersion Property

Given two filtrations $\mathbb F \subset \mathbb G$, we study under which conditions the $\mathbb F$-optional projection and the $\mathbb F$-dual optional projection coincide for the class of $\mathbb G$-optional processes with integrable variation. It turns out that this property is equivalent to the immersion property for $\mathbb F$ and $\mathbb G$, that is every $\mathbb F$-local martingale is a $\mathbb G$-local martingale, which, equivalently, may be characterised using the class of $\mathbb F$-pseudo-stopping times. We also show that every $\mathbb G$-stopping time can be decomposed into the minimum of two barrier hitting times

Stability of the utility maximization problem with random endowment in incomplete markets

We perform a stability analysis for the utility maximization problem in a general semimartingale model where both liquid and illiquid assets (random endowments) are present. Small misspecifications of preferences (as modeled via expected utility), as well as views of the world or the market model (as modeled via subjective probabilities) are considered. Simple sufficient conditions are given for the problem to be well-posed, in the sense the optimal wealth and the marginal utility-based prices are continuous functionals of preferences and probabilistic views.Comment: 21 pages, revised version. To appear in "Mathematical Finance"

Primary Motor Cortex Excitability Is Modulated during the Mental Simulation of Hand Movement

Special issue: Motor cognitio

Genes Suggest Ancestral Colour Polymorphisms Are Shared across Morphologically Cryptic Species in Arctic Bumblebees

email Suzanne orcd idCopyright: © 2015 Williams et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited