3,556 research outputs found

    Intrinsic and Extrinsic Performance Limits of Graphene Devices on SiO2

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    The linear dispersion relation in graphene[1,2] gives rise to a surprising prediction: the resistivity due to isotropic scatterers (e.g. white-noise disorder[3] or phonons[4-8]) is independent of carrier density n. Here we show that acoustic phonon scattering[4-6] is indeed independent of n, and places an intrinsic limit on the resistivity in graphene of only 30 Ohm at room temperature (RT). At a technologically-relevant carrier density of 10^12 cm^-2, the mean free path for electron-acoustic phonon scattering is >2 microns, and the intrinsic mobility limit is 2x10^5 cm^2/Vs, exceeding the highest known inorganic semiconductor (InSb, ~7.7x10^4 cm^2/Vs[9]) and semiconducting carbon nanotubes (~1x10^5 cm^2/Vs[10]). We also show that extrinsic scattering by surface phonons of the SiO2 substrate[11,12] adds a strong temperature dependent resistivity above ~200 K[8], limiting the RT mobility to ~4x10^4 cm^2/Vs, pointing out the importance of substrate choice for graphene devices[13].Comment: 16 pages, 3 figure

    Kyai Leadership in Internalizing Nationalism Values at Pesantren

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    This study aims to examine the leadership of the kyai in Pesantren Salâfiyah Cidahu Pandeglang. It specifically explored the leadership of the kyai and its role in internalizing nationalism values for students in pesantren. This study used a descriptive-qualitative method. The data were obtained through interviews, observation and documentation. The results showed that the leadership of the kyai has played a role in internalizing a spirit of nationalism for the students. The process of internalizing the spirit of nationalism was carried out through giving advice and exemplary, book recitation activities, baḥṡ al-masâ'il, community service, entrepreneurial activities, organizational activities, leadership training, maintaining traditions, and democracy-related activities. Lack of the students' motivation to learn and the limited facilities and infrastructure were the obstacles in nurturing the values of nationalism. To solve the obstacles, kyai provided motivation for the students, built the students' confidence and self-confidence, and established network with the society and government

    Kyai Leadership in Internalizing Nationalism Values at Pesantren

    Get PDF
    This study aims to examine the leadership of the kyai in Pesantren Salâfiyah Cidahu Pandeglang. It specifically explored the leadership of the kyai and its role in internalizing nationalism values for students in pesantren. This study used a descriptive-qualitative method. The data were obtained through interviews, observation and documentation. The results showed that the leadership of the kyai has played a role in internalizing a spirit of nationalism for the students. The process of internalizing the spirit of nationalism was carried out through giving advice and exemplary, book recitation activities, baḥṡ al-masâ'il, community service, entrepreneurial activities, organizational activities, leadership training, maintaining traditions, and democracy-related activities. Lack of the students' motivation to learn and the limited facilities and infrastructure were the obstacles in nurturing the values of nationalism. To solve the obstacles, kyai provided motivation for the students, built the students' confidence and self-confidence, and established network with the society and government

    The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster

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    The regulatory protein NsrR, a member of the Rrf2 family of transcription repressors, is specifically dedicated to sensing nitric oxide (NO) in a variety of pathogenic and non-pathogenic bacteria. It has been proposed that NO directly modulates NsrR activity by interacting with a predicted [Fe-S] cluster in the NsrR protein, but no experimental evidence has been published to support this hypothesis. Here we report the purification of NsrR from the obligate aerobe Streptomyces coelicolor. We demonstrate using UV-visible, near UV CD and EPR spectroscopy that the protein contains an NO-sensitive [2Fe-2S] cluster when purified from E. coli. Upon exposure of NsrR to NO, the cluster is nitrosylated, which results in the loss of DNA binding activity as detected by bandshift assays. Removal of the [2Fe-2S] cluster to generate apo-NsrR also resulted in loss of DNA binding activity. This is the first demonstration that NsrR contains an NO-sensitive [2Fe-2S] cluster that is required for DNA binding activity

    The Missing Link! A New Skeleton for Evolutionary Multi-agent Systems in Erlang

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    Evolutionary multi-agent systems (EMAS) play a critical role in many artificial intelligence applications that are in use today. In this paper, we present a new generic skeleton in Erlang for parallel EMAS computations. The skeleton enables us to capture a wide variety of concrete evolutionary computations that can exploit the same underlying parallel implementation. We demonstrate the use of our skeleton on two different evolutionary computing applications: (1) computing the minimum of the Rastrigin function; and (2) solving an urban traffic optimisation problem. We show that we can obtain very good speedups (up to 142.44 ×× the sequential performance) on a variety of different parallel hardware, while requiring very little parallelisation effort.Publisher PDFPeer reviewe

    Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms

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    Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional susceptibility loci await identification. An efficient discovery strategy may be larger-scale evaluation of promising associations suggested by genome-wide association studies (GWAS). Hence, we genotyped 56,309 participants using a targeted gene array derived from earlier GWAS results and performed meta-analysis of results with 194,427 participants previously genotyped, totaling 88,192 CAD cases and 162,544 controls. We identified 25 new SNP-CAD associations (P < 5 × 10(-8), in fixed-effects meta-analysis) from 15 genomic regions, including SNPs in or near genes involved in cellular adhesion, leukocyte migration and atherosclerosis (PECAM1, rs1867624), coagulation and inflammation (PROCR, rs867186 (p.Ser219Gly)) and vascular smooth muscle cell differentiation (LMOD1, rs2820315). Correlation of these regions with cell-type-specific gene expression and plasma protein levels sheds light on potential disease mechanisms
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