Enhancing Persistence on Mastery Tasks Among Young Preschool Children by Implementing the “I Can” Mastery Motivation Classroom Program

Task persistence plays important role in school readiness and helps to enhance young children’s cognitive development and academic skills; thus, designing and implementing programs to enhance it is vital. The objective of the present research was to assess the effectiveness of the “I Can” mastery motivation classroom program in enhancing young children’s persistence on mastery tasks. Altogether, forty-four (n = 44) children between the ages of two to three years selected from three kindergartens in Malaysia participated in the research, which was conducted by using a randomized pretest and posttest experimental-control group design. Persistence on three mastery tasks and mastery pleasure were assessed by using the Individualized Assessment of Mastery Motivation manual. The experimental group (n = 25) was exposed to the “I Can” mastery motivation classroom program, while the control group (n = 19) attended regular classroom lessons. There was a significant gain score difference between the experimental and control groups on task persistence for puzzles but not for shape sorters, cause and effect toys, and mastery pleasure. Thus, the program was effective in enhancing persistence on some mastery tasks. The content and findings of the intervention should help policy makers understand this important aspect of early childhood education

PENGARUH INDEPENDENSI, KOMPETENSI DAN FEE AUDIT TERHADAP KUALITAS AUDIT (Survey pada 10 Kantor Akuntan Publik di Kota Bandung)

ABSTRAK Penelitian ini bertujuan untuk mengetahui besarnya pengaruh independensi, kompetensi dan fee audit terhadap kualitas audit pada Kantor Akuntan Publik yang terdaftar pada IAPI di Kota Bandung. Pendekatan penelitian yang digunakan dalam penelitian ini adalah analisis deskriptif dan verifikatif dengan menggunakan data primer. Teknik sampling yang digunakan adalah non probability sampling dengan metode simple random sampling. Analisis statistik yang digunakan dalam penelitian ini adalah uji asumsi klasik, analisis regresi, korelasi, pengujian hipotesis dengan menggunakan uji t dan uji f serta analisis koefisien determinasi. Banyaknya populasi penelitian adalah 10 kantor akuntan publik (KAP) terdaftar pada IAPI Bandung, sampel penelitian yang digunakan adalah 72 orang dengan sumber data yang diperoleh melalui hasil pengisian kuesioner. Berdasarkan hasil penelitian yang dilakukan dapat diketahui bahwa secara parsial besarnya pengaruh independensi sebesar 15,2%, kompetensi sebesar 36,8%, dan fee audit sebesar 11,9% terhadap kualitas audit. Secara simultan pengaruh independensi, kompetensi, dan fee audit terhadap kualitas audit sebesar 63,9%, sedangkan sisanya 36,1% merupakan faktor lain di luar ketiga variabel independen yang sedang diteliti, seperti faktor profesionalisme, etika, rotasi auditor dan integritas auditor. Kata Kunci: Independensi, Kompetensi, Fee Audit dan Kualitas Audit

Hydrodynamics of R-charged D1-branes

We study the hydrodynamic properties of strongly coupled $SU(N)$ Yang-Mills theory of the D1-brane at finite temperature and at a non-zero density of R-charge in the framework of gauge/gravity duality. The gravity dual description involves a charged black hole solution of an Einstein-Maxwell-dilaton system in 3 dimensions which is obtained by a consistent truncation of the spinning D1-brane in 10 dimensions. We evaluate thermal and electrical conductivity as well as the bulk viscosity as a function of the chemical potential conjugate to the R-charges of the D1-brane. We show that the ratio of bulk viscosity to entropy density is independent of the chemical potential and is equal to $1/4\pi$. The thermal conductivity and bulk viscosity obey a relationship similar to the Wiedemann-Franz law. We show that at the boundary of thermodynamic stability, the charge diffusion mode becomes unstable and the transport coefficients exhibit critical behaviour. Our method for evaluating the transport coefficients relies on expressing the second order differential equations in terms of a first order equation which dictates the radial evolution of the transport coefficient. The radial evolution equations can be solved exactly for the transport coefficients of our interest. We observe that transport coefficients of the D1-brane theory are related to that of the M2-brane by an overall proportionality constant which sets the dimensions.Comment: 57 pages, 12 figure

MODEL PENARAFAN HOTEL DAN CHALET PATUH SYARIAH: SATU KAJIAN KONSEPSUAL DI NEGERI MELAKA

Industri pelancongan adalah salah satu industri penting yang menjadi sumber penting oleh kerajaan dalam memacu pertumbuhan ekonomi negara. Sebahagian daripada negeri-negeri di Malaysia sememangnya menjadikan pelancongan sebagai di antara sumber utama ekonomi negeri seperti yang dilaksanakan di negeri Melaka. Model ekonomi baru yang telah diperkenalkan oleh kerajaan telah menyenaraikan sektor pelancongan sebagai salah satu sektor yang berpotensi untuk merancakkan pertumbuhan dan menjana hasil pendapatan negara. Salah satu produk pelancongan yang berpotensi untuk diketengahkan ialah hotel patuh shariah (shariah-compliant hotels). Ianya merupakan konsep pengurusan perhotelan yang semakin mendapat tempat di negara-negara Timur Tengah seperti di UAE dan juga Arab Saudi. Selain itu juga, kesedaran masyarakat tentang produk patuh syariah juga sangat memberansangkan serta keyakinan masyarakat terhadap produk patuh syariah semakin meningkat hasil kempen dan penerangan berterusan badan-badan agama di Malaysia. Kertas kerja ini membincangkan tentang kriteria yang perlu ada untuk penarafan hotel patuh syariah di negeri Melaka. Melihat kepada pertambahan bilangan pelancong setiap tahun yang menngunakan perkhidmatan sewaan hotel dan chalet di negeri Melaka, maka penarafan hotel patuh syariah perlu diperkenalkan bagi memudahkan para pengguna mendapatkan perkhidmatan sewaan hotel atau chalet tanpa ada keraguan serta selamat dari sudut syarak. Dengan penarafan ini juga sudah pasti akan merancakkan lagi industri pelancongan dengan penambahan bilangan pelancong di negeri Melaka khususnya yang menggunakan perkhidmatan sewaan hotel dan chalet patuh syariah.

Modelling the impact of atherosclerosis on drug release and distribution from coronary stents

Although drug-eluting stents (DES) are now widely used for the treatment of coronary heart disease, there remains considerable scope for the development of enhanced designs which address some of the limitations of existing devices. The drug release profile is a key element governing the overall performance of DES. The use of in vitro, in vivo, ex vivo, in silico and mathematical models has enhanced understanding of the factors which govern drug uptake and distribution from DES. Such work has identified the physical phenomena determining the transport of drug from the stent and through tissue, and has highlighted the importance of stent coatings and drug physical properties to this process. However, there is limited information regarding the precise role that the atherosclerotic lesion has in determining the uptake and distribution of drug. In this review, we start by discussing the various models that have been used in this research area, highlighting the different types of information they can provide. We then go on to describe more recent methods that incorporate the impact of atherosclerotic lesions

Ustekinumab as Induction and Maintenance Therapy for Crohn’s Disease

BACKGROUND Ustekinumab, a monoclonal antibody to the p40 subunit of interleukin-12 and inter-leukin-23, was evaluated as an intravenous induction therapy in two populations with moderately to severely active Crohn’s disease. Ustekinumab was also evaluated as subcutaneous maintenance therapy. METHODS We randomly assigned patients to receive a single intravenous dose of ustekinumab (either 130 mg or approximately 6 mg per kilogram of body weight) or placebo in two induction trials. The UNITI-1 trial included 741 patients who met the criteria for primary or secondary nonresponse to tumor necrosis factor (TNF) antagonists or had unacceptable side effects. The UNITI-2 trial included 628 patients in whom conventional therapy failed or unacceptable side effects occurred. Patients who completed these induction trials then participated in IM-UNITI, in which the 397 patients who had a response to ustekinumab were randomly assigned to receive subcutaneous maintenance injections of 90 mg of ustekinumab (either every 8 weeks or every 12 weeks) or placebo. The primary end point for the induction trials was a clinical response at week 6 (defined as a decrease from baseline in the Crohn’s Disease Activity Index [CDAI] score of ≥100 points or a CDAI score <150). The primary end point for the maintenance trial was remission at week 44 (CDAI score <150). RESULTS The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, with P≤0.003 for both comparisons with placebo; in UNITI-2, 51.7%, 55.5%, and 28.7%, respectively, with P<0.001 for both doses). In the groups receiving maintenance doses of ustekinumab every 8 weeks or every 12 weeks, 53.1% and 48.8%, respectively, were in remission at week 44, as compared with 35.9% of those receiving placebo (P = 0.005 and P = 0.04, respectively). Within each trial, adverse-event rates were similar among treatment groups. CONCLUSIONS Among patients with moderately to severely active Crohn’s disease, those receiving intravenous ustekinumab had a significantly higher rate of response than did those receiving placebo. Subcutaneous ustekinumab maintained remission in patients who had a clinical response to induction therapy. (Funded by Janssen Research and Development; ClinicalTrials.gov numbers, NCT01369329, NCT01369342, and NCT01369355.

PENGARUH LEVERAGE, DAN PROFITABILITAS TERHADAP HARGA SAHAM (Pada Industri Barang Konsumsi Sub Sektor Makanan & Minuman di Indeks Saham Syariah Indonesia Periode 2013–2017)

ABSTRAK Penelitian ini bertujuan untuk mengetahui kondisi Leverage yang diukur dengan Debt to Equity Ratio, dan Profitabilitas yang diukur dengan Return On Assets dan Harga Saham, serta untuk mengetahui seberapa besar pengaruh variabel Leverage yang diukur dengan Debt to Equity Ratio, dan Profitabilitas yang diukur dengan Return On Assets terhadap Harga Saham pada industri barang konsumsi sub sektor makanan dan minuman di Indeks Saham Syariah Indonesia periode 2013–2017. Sampel dalam penelitian ini berjumlah 11 perusahaan. Metode penelitian yang digunakan adalah analisis regresi berganda, uji hipotesis yaitu analisis korelasi berganda, dan analisis koefisien determinasi parsial dan simultan. Sebelumnya dilakukan uji asumsi klasik untuk mengetahui ketepatan analisis regresi linier. Hasil penelitian menunjukkan bahwa (Debt to Equity Ratio), dan Profitabilitas (Return On Assets) secara simultan maupun parsial berpengaruh signifikan terhadap Harga Saham. Secara simultan pengaruhnya adalah 10,5% dan sisanya 89,5% dipengaruhi oleh variabel lain. Variabel yang berpengaruh dominan adalah Profitabilitas (Return On Assets). Kata Kunci : Leverage (Debt to Equity Ratio), Profitabilitas (Return On Assets), dan Harga Saham

Right ventricular outflow tract obstruction in twin-to-twin transfusion syndrome undergoing laser surgery: A systematic review and meta-analysis.

INTRODUCTION: We aimed to investigate the incidence, prenatal factors and outcomes of twin-to-twin transfusion (TTTS) with right ventricular outflow tract obstruction (RVOTO). MATERIAL AND METHODS: A systematic search was conducted to identify relevant studies published until February 2023 in English using the databases PubMed, Scopus and Web of Science. Studies reporting on pregnancies with TTTS and RVOTO were included. The random-effect model pooled the mean differences or odds ratios (OR) and the corresponding 95% confidence intervals. Heterogeneity was assessed using the I2 value. RESULTS: A total of 17 studies encompassing 4332 TTTS pregnancies, of which 225 cases had RVOTO, were included. Incidence of RVOTO at time of TTTS diagnosis was 6%. In all, 134/197 (68%) had functional pulmonary stenosis and 62/197 (32%) had functional pulmonary atresia. Of these, 27% resolved following laser and 55% persisted after birth. Of those persisting, 27% required cardiac valve procedures. Prenatal associations were TTTS stage III (53% vs 39% in no-RVOTO), stage IV TTTS (28% in RVOTO vs 12% in no-RVOTO) and ductus venosus reversed a-wave (60% in RVOTO vs 19% in no-RVOTO). Gestational age at laser and gestational age at delivery were comparable between groups. Survival outcomes were also comparable between groups, including fetal demise of 26%, neonatal death of 12% and 6-month survival of 82% in RVOTO group. Findings were similar when subgroup analysis was done for studies including head-to-head analysis. CONCLUSIONS: RVOT occurs in about 6% of the recipient twins with TTTS, especially in stages III and IV and those with reversed ductus venosus a-wave. The findings from this systematic review support the need for a thorough cardiac assessment of pregnancies complicated by TTTS, both before and after laser, to maximize perinatal outcome, and the importance of early diagnosis of TTTS and timely management

Pengaruh Nilai Etis Perusahaan, Kepemimpinan Etis terhadap Komitmen Religius dan Kinerja Karyawan (Studi pada Bank Syariah di Kota Pasuruan dan Kota Probolinggo)

Penelitian ini bertujuan untuk meneliti efek moderasi dari variable religiusitas pada hubungan antara kepemimpinan etis terhadap komitmen organisasional dan kinerja karyawan yang dilakukan pada bank syariah di kota pasuruan dan kota probolinggo provinsi jawa timur indonesia Penelitian ini menggunakan metode pendekatan positivist atau kuantitatif karena bertujuan menguji hipotesis. Jenis perusahaan adalah perbankan Syariah yang terdapat di Kota Pasuruan dan Kota Probolinggo. Status perusahaan adalah perusahaan BUMN dan swasta, jumlah populasi adalah 109 orang. Populasi yang digunakan dalam penelitian ini adalah seluruh karyawan selain level pimpinan yang tercatat sebagai karyawan tetap di Bank Syariah tersebut. Penelitian ini merupakan penelitian survey sehingga alat pengumpulan data yang digunakan adalah instrumen penelitian. Pengujian validitas dan reliabilitas disajikan. Secara umum metode explanatory research adalah pendekatan metode yang menggunakan PLS. Hal ini disebabkan pada metode ini terdapat pengujian Hipotesa. Menguji hipotesis dapat dilihat dari nilai t-statistik dan nilai probabilitas. Hasil penelitian menunjukkan bahwa kepemimpinan Etis mempunyai pengaruh yang signifikan terhadap Komitmen organisasional dan kinerja karyawan, efek moderasi variable religiusitas juga mampu memoderasi dengan temuan meningkatkan interaksi antara kepemimpinan etis terhadap komitmen dan kinerja karyawan, tetapi hubungan antara nilai etis perusahaan terhadap komitmen mendapatkan hasil tidak signifikan. Temuan penelitian ini memberikan kontribusi kepada perusahaan, bahwa ada pengaruh yang diberikan efek moderasi dari religiusitas yang mampu meningkatkan hubungan antara kepemimpinan etis terhadap komitmen dan kinerja karyawa

Prognostic role of EGFR gene copy number and KRAS mutation in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy

Epidermal growth factor receptor (EGFR), evaluated by immunohistochemistry, has been shown to have prognostic significance in patients with colorectal cancer. Gene copy number (GCN) of EGFR and KRAS status predict response and outcome in patients treated with anti-EGFR therapy, but their prognostic significance in colorectal cancer patients is still unclear.We have retrospectively reviewed the baseline EGFR GCN, KRAS status and clinical outcome of 146 locally advanced rectal cancer (LARC) patients treated with preoperative chemoradiotherapy. Pathological response evaluated by Dworak's tumour regression grade (TRG), disease-free survival (DFS) and overall survival (OS) were analysed.Tumour regression grade 4 and TRG3-4 were achieved in 14.4 and 30.8\% of the patients respectively. Twenty-nine (19.9\%) and 33 patients (19.2\%) had an EGFR/nuclei ratio >2.9 and CEP7 polisomy >50\% respectively; 28 patients (19.2\%) had a KRAS mutation. Neither EGFR GCN nor KRAS status was statistically correlated to TRG. 5-year DFS and OS were 63.3 and 71.5\%, respectively, and no significant relation with EGFR GCN or KRAS status was found.Our data show that EGFR GCN and KRAS status are not prognostic factors in LARC treated with preoperative chemoradiation