282 research outputs found

    Evaluation of Environmental Life Cycle Approaches for Policy and Decision Making Support in Micro and Macro Level Applications

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    The European Commission (EC) has strengthened environmental and sustainability oriented policies and strategies by introducing Life Cycle Thinking. Amongst others, this is a key consideration in the Integrated Product Policy Communication, the two Thematic Strategies on the Sustainable Use of Natural Resources and on the Prevention and Recycling of Waste, as well as in the Sustainable Consumption and Production (SCP)/Sustainable Industry Policy (SIP) Action Plan. Reliable and scientifically robust life cycle methods are required to support the implementation, monitoring and assessment needs of these strategies and associated policies. This project analyses different life-cycle methods and provides an evaluation of their current suitability for assessing environmental impacts in micro level and macro level situations.JRC.DDG.H.8-Sustainability Assessmen

    Life Cycle Assessment of Pavements: A Critical Review of Existing Literature and Research

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    This report provides a critical review of existing literature and modeling tools related to life-cycle assessment (LCA) applied to pavements. The review finds that pavement LCA is an expanding but still limited research topic in the literature, and that the existing body of work exhibits methodological deficiencies and incompatibilities that serve as barriers to the widespread utilization of LCA by pavement engineers and policy makers. This review identifies five key issues in the current body of work: inconsistent functional units, improper system boundaries, imbalanced data for asphalt and cement, use of limited inventory and impact assessment categories, and poor overall utility. This review also identifies common data and modeling gaps in pavement LCAs that should be addressed in future work. These gaps include: the use phase (rolling resistance, albedo, carbonation, lighting, leachate, and tire wear and emissions), asphalt fumes, feedstock energy of bitumen, traffic delay, the maintenance phase, and the end-of-life phase. This review concludes with a comprehensive list of recommendations for future research, which shed light on where improvements in knowledge can be made that will benefit the accuracy and comprehensiveness of pavement LCAs moving forward

    What are the energy and greenhouse gas benefits of repurposing non-residential buildings into apartments?

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    This study examines the potential strategies for reducing embodied energy and greenhouse gas emissions through adaptive reuse of non-residential buildings for residential purposes, as compared to new construction of apartment buildings. Such an approach can address housing crises in urban areas with an abundance of underutilized non-residential buildings, promoting sustainable housing growth. A comprehensive assessment of repurposing in California reveals approximately 510 million m² of floor space across 230,000 non-residential buildings in the current building stock. The potential reduction in embodied energy and CO2eq emissions ranges from 0.14 to 1.4 billion GJ and 5.0–70 million metric tons for the state, respectively, contingent upon the percentage of repurposed floor space (10–100%) and adaptive reuse scenario (retaining structural components and façade or solely the structure). A repurposed building avoids about 56% of embodied energy, 34-48% of CO2 eq emissions, and 72% of materials by mass compared to building a new apartment building. However, various technical, financial, and regulatory challenges may hinder emissions reductions, necessitating proactive policy measures. Cities can potentially expedite the process by streamlining approvals for mixed-use adaptive reuse projects involving both commercial and residential spaces

    Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution

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    Skeletal muscle is constantly renewed in response to injury, exercise, or muscle diseases. Muscle stem cells, also known as satellite cells, are stimulated by local damage to proliferate extensively and form myoblasts that then migrate, differentiate, and fuse to form muscle fibers. The transmembrane heparan sulfate proteoglycan syndecan-4 plays multiple roles in signal transduction processes, such as regulating the activity of the small GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) by binding and inhibiting the activity of Tiam1 (T-lymphoma invasion and metastasis-1), a guanine nucleotide exchange factor for Rac1. The Rac1-mediated actin remodeling is required for cell migration. Syndecan-4 knockout mice cannot regenerate injured muscle; however, the detailed underlying mechanism is unknown. Here, we demonstrate that shRNA-mediated knockdown of syndecan-4 decreases the random migration of mouse myoblasts during live-cell microscopy. Treatment with the Rac1 inhibitor NSC23766 did not restore the migration capacity of syndecan-4 silenced cells; in fact, it was further reduced. Syndecan-4 knockdown decreased the directional persistence of migration, abrogated the polarized, asymmetric distribution of Tiam1, and reduced the total Tiam1 level of the cells. Syndecan-4 affects myoblast migration via its role in expression and localization of Tiam1; this finding may facilitate greater understanding of the essential role of syndecan-4 in the development and regeneration of skeletal muscle

    Vitrifikacija mleča grgeča (perca fluviatilis)

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    Vitrifikacija je proces dovođenja vode ili rastvora u čvrsto stanje, odnosno u amorfno ili staklasto stanje koje može da se dostigne veoma brzom hlađenjem (106-1010 °C/s). Nedavno je objavljeno nekoliko istraživanja o vitrifikaciji mleča različitih vrsta riba, međutim nema dostupnih informacija o vitrifikaciji mleča grgeča (Perca fluviatilis). Mužjaci grgeča su uzorkovani 6 dana posle hormonske injekcije (250 IU kg-1 hCG). Evaluirana je pokretljivost spermatozoida pomoću sistema kompjuterske analize sperme CASA. Za process vitrifikacije mleč je razblažen modifikovanim Tanaka ekstenderom na finalni odnos 1:5 (sa krioprotektantima). Posle preliminarnih testova sa kombinacijom metanola i propilen glikola (PG) u različitim koncentracijama, odlučeno je da se koristi 15% metanola i 15 % PG (ukupno 30% krioprotektanata). Suspenzija mleča je ubačena direktno u tečni azot bez prethodnog hlađenja u njegovoj pari. Za sve eksperimente vitrifikacije za hlađenje su korišćene cevčice Cryotop (Kitazato-Dibimed, za 2 µl rastvora). Za fertilizacioni test su prikupljena jaja ženki grgeča. Vitrifikovane Cryotop cevčice otopljene su direktno u 10 µl rastvora za aktivaciju (50 mm NaCl) u petri šoljama koje su sadržale jaja. Svež mleč služio je za kontrolu. Oplođena jaja su inkubirana u plivajućem sistemu. Izvedena su 3 ogleda da bi se utvrdio odgovarajući broj cevčica Cryotop za svaku seriju jaja: 1, 6 i 18 cevčica Cryotop je isprobano za svaku seriju jajnih ćelija. U 2 µl rastvora mleča jedne Cryotop cevčice bilo je oko 0,33 µl mleča. Na osnovu stepena oplođenja u tri ogleda može se zaključiti da povećanje broja Cryotop cevčica pojačava stepen oplođenja. Dalja sitraživanja su neophodna da bi se razvio metod vitrifikacije sa većim preživljavanjem larvi posle oplođenja vitrifikovanim mlečom. Takođe je potrebno ispitati stepen izvaljenih embriona iz ogleda sa vitrifikovanim mlečom, kao i potencijalni uticaj vitrifikacije na larve, pre svega na deformitete i morfološke promene

    Environmental analysis of milling machine tool use in various manufacturing environments

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    A life-cycle energy consumption analysis of a Bridgeport manual mill and a Mori Seiki DuraVertical 5060 has been conducted. The use phase incorporated three manufacturing environments: a community shop, a job shop, and a commercial facility. The CO2-equivalent emissions were presented per machined part. While the use phase comprised the majority of the overall emissions, the manufacturing phase emissions were significant especially for the job shop, which is not as efficient as the other facilities due to its inherent need for flexibility. Since the Mori Seiki is heavier, the manufacturing phase of this machine tool had a greater impact on emissions than the Bridgeport. Transportation was small relative to the use phase, which was dominated by cutting, HVAC, and lighting. These results highlight areas for energy reductions in machine tool design as well as the importance of facility type to the manufacture of any product
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