Application of policy-led multi-criteria analysis to the appraisal of the Northern Line Extension, London

This paper seeks to both illustrate and act as a proof of concept of how a policy-led multi-criteria analysis framework and its attendant process of the type introduced in the second paper, ‘Theory and Background of Multi-Criteria Analysis: Toward a policy-led approach for mega transport project infrastructure appraisal’, can be applied to the appraisal of a mega transport project in the form of the Northern Line Extension in London. It is offered with a view to help better identify the distribution of the projects costs and benefits and shed greater light on the possible ‘winners’ and ‘losers’ over space and time, and under given scenarios. Drawing from an extensive array of public domain literature the paper sets out both the policy and planning contexts for the project plus the business case that led to a decision by UK Treasury to guarantee a £1 billion loan to Transport for London for the construction of the Northern Line's extension. The paper looks at the scale and nature of the megaproject's features, particularly its line-haul and related real estate developments, especially those in the assigned development opportunity area. The text presents the policy, planning, legislative and regulative dimensions of the project likely to define its revenue generation prospects and environmental and social impacts, with special attention paid to those project outcomes affecting key stakeholders over time and space. The paper also seeks to explain the mechanics of how to employ a policy-led multi-criteria framework together with its associated processes within which stakeholder policies and agendas can be mapped and common/divergent interests identified. This is done with a view to ultimately facilitate stakeholder negotiation decision-making trade-offs in given scenarios under the policy guidance of the Greater London Authority with the support of the Treasury of the UK Government

Presenting the case for the application of multi-criteria analysis to mega transport infrastructure project appraisal

The paper commences with an overview of mega transport infrastructure decision-making as it relates to the megaproject development cycle and challenges of sustainable development, which are increasingly redefining the criterion for the evaluation of project success. The body of the paper presents a brief critique of various appraisal applications to mega transport infrastructure projects, including: Social Cost Benefit Analysis; Cost Effectiveness Analysis; Goal Achievement Matrix Methods and the Planning Balance Sheet, highlighting the merits and demerits of the outlined approaches. Here particular reference is made to the power of context on decision-making and other lessons from OMEGA Centre research. These include, most importantly, the treatment of risk, uncertainty and complexity of developments outside of the project and the challenges of meeting multiple stakeholder aspirations/needs thereby building up the case for the introduction and use of multi-criteria analysis and policy-led multi-criteria analysis to the appraisal of Mega Transport Projects

Evaluation of risk management practices: data analysis of NHS England hospitals

Risk management practices are applied in the National Health Service (NHS) England hospitals to reduce harm rates and to ensure safety. This study evaluates current risk management practices in the NHS England hospitals through highlighting non-compliance issues within the practice and through explaining board level risk priorities. All data were collected for selected (N=34) NHS England hospitals. Data were gathered from the NHS Litigation Authority (NHSLA) reports to reveal risk management problems and from Board Assurance Frameworks (BAF) to define top risks. Results from an external authority of the NHSLA show that local induction of staff is a major non-compliance issue for risk management practice with more than half of the hospitals having difficulties. Following that supervision of medical staff in training is the second highly observed deficiency. Results from hospitals’ board level demonstrate that top risks in hospitals were regarding quality and performance issues. Additionally, most of the board level defined top risks were categorized as organizational and clinical-related risks. Within these, workforce issues and non-compliance with requirements are highlighted as top risks for organizational-related risks while Accident and Emergency (A&E) targets and treatment delays are prioritized as part of clinical-related risks. Financial deficit is also frequently defined at board level as a top risk for financial-related risks. Both the NHSLA and hospital board level assessments show that workforce related issues are still a major concern in hospital risk management practices. It is therefore a slight influence of an external authority (NHSLA) has been recognized on prioritization of board level defined risks

How does gender influence the recognition of cardiovascular risk and adherence to self-care recommendations? : a study in polish primary care

Background: Studies have shown a correlation between gender and an ability to change lifestyle to reduce the risk of disease. However, the results of these studies are ambiguous, especially where a healthy lifestyle is concerned. Additionally, health behaviors are strongly modified by culture and the environment. Psychological factors also substantially affect engagement with disease-related lifestyle interventions. This study aimed to examine whether there are differences between men and women in the frequency of health care behavior for the purpose of reducing cardiovascular risk (CVR), as well as cognitive appraisal of this type of risk. We also aimed to identify the psychological predictors of engaging in recommended behavior for reducing the risk of cardiovascular disease after providing information about this risk in men and women. Methods: A total of 134 consecutive eligible patients in a family practice entered a longitudinal study. At initial consultation, the individual’s CVR and associated health burden was examined, and preventive measures were recommended by the physician. Self-care behavior, cognitive appraisal of risk, and coping styles were then assessed using psychological questionnaires. Six months after the initial data collection, the frequency of subjects’ self-care behavior was examined. Results: We found an increase in health care behavior after providing information regarding the rate of CVR in both sexes; this increase was greater for women than for men. Women followed self-care guidelines more often than men, particularly for preventive measures and dietary advice. Women were more inclined to recognize their CVR as a challenge. Coping style, cognitive appraisal, age, level of health behaviors at baseline and CVR values accounted for 48% of the variance in adherence to self-care guidelines in women and it was 52% in men. In women, total risk of CVD values were most important, while in men, cognitive appraisal of harm/loss was most important. Conclusions: Different predictors of acquisition of health behavior are encountered in men and women. Our results suggest that gender-adjusted motivation models influencing the recognition process need to be considered to optimize compliance in patients with CVR

Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans

Peer reviewedPublisher PD

Theory and Background of Multi-Criteria Analysis: Toward a policy-led approach for mega transport project infrastructure appraisal

The aims of this paper are twofold. Firstly, to present a review and critical analysis of the varying forms and functions of Multi-Criteria Analysis presented in the literature, and secondly, drawing from this, to introduce methods and processes by which policy leadership can be introduced into such processes for the appraisal of large-scale transport infrastructure projects to form a policy-led multi-criteria analysis. Following the discussion in the first paper of this Special Issue, ‘Presenting the Case for the Application of Multi-Criteria Analysis to Mega Transport Project Infrastructure Appraisal’, this contribution commences by outlining further the generic features and challenges of multi-criteria analysis approaches to project appraisal whilst emphasizing the difference among various frameworks and attendant processes for such approaches. It also highlights the important role/value of the multi-criteria mapping of stakeholder policies and agendas affecting project decision-making as a means of defining and scoping the boundaries of the project exercise under study and the trade-off decision-spaces for stakeholder dialogues and negotiations in their search to arrive at mutually agreed actions and outcomes. The paper discusses how multi-criteria analysis frameworks can be tailor-designed for particular agencies and stakeholders developed around problems, challenges and issues. This is done in the acknowledgement that such exercises, especially when applied to mega infrastructure project appraisal, typically attract a multiple-institutional response and where ultimately an institutional leader (or partnership of stakeholders) exists/emerges that impose its/their priorities on others. Alternatively, the approach can be tailor-made for specific institutions with its imbedded hierarchy of policies and priorities that frame the stakeholder decision space within which other parties can participate and trade off interests. The first part of the paper highlights the important role of scenarios of policy-making contexts and policy leadership indicating the new risks, uncertainties and opportunities these may offer in multi-criteria analysis exercises, indicating that some/many past processes have been conducted outside of any real reference to such matters. In so doing, such applications have them silently and implicitly adopt scenarios and policy assumptions that are not transparent frequently reflecting, it is alleged, ‘business as usual’ circumstances in contexts when the signs are very much that these trends will not/cannot prevail. The authors contend that without explicit policy leadership there is a danger that certain institutional stakeholder priorities will be imposed over others by the most powerful without adequate dialogue. Understanding that this matters a great deal in contexts when project stakeholder powers shifts occur is very significant. Examples of such circumstances are when national governments become, less or more powerful and economically affluent, when relative legislative and regulation powers become less or more binding and powerful, and when a major private sector investor upon which a project depends goes bankrupt. The second half of the paper builds on these observations to offer a generic multi-criteria analysis framework and attendant processes that imbed policy leadership firmly within multi-stakeholder decision-making (termed Policy-led Multi-criteria Analysis). The framework developed is to be applied to mega transport projects via the use of suitable appraisal criteria in the pursuit of sustainable development goals, which seek to address both quantitative and qualitative dimensions and concerns of multiple stakeholders, with particular emphasis on the processes required to identify and incorporate suitable policy leadership, including feedback between appraisal and policy

Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

Host Cell Transcriptome Profile during Wild-Type and Attenuated Dengue Virus Infection

10.1371/journal.pntd.0002107PLoS Neglected Tropical Diseases73

Urban Biodiversity and Landscape Ecology: Patterns, Processes and Planning

Effective planning for biodiversity in cities and towns is increasingly important as urban areas and their human populations grow, both to achieve conservation goals and because ecological communities support services on which humans depend. Landscape ecology provides important frameworks for understanding and conserving urban biodiversity both within cities and considering whole cities in their regional context, and has played an important role in the development of a substantial and expanding body of knowledge about urban landscapes and communities. Characteristics of the whole city including size, overall amount of green space, age and regional context are important considerations for understanding and planning for biotic assemblages at the scale of entire cities, but have received relatively little research attention. Studies of biodiversity within cities are more abundant and show that longstanding principles regarding how patch size, configuration and composition influence biodiversity apply to urban areas as they do in other habitats. However, the fine spatial scales at which urban areas are fragmented and the altered temporal dynamics compared to non-urban areas indicate a need to apply hierarchical multi-scalar landscape ecology models to urban environments. Transferring results from landscape-scale urban biodiversity research into planning remains challenging, not least because of the requirements for urban green space to provide multiple functions. An increasing array of tools is available to meet this challenge and increasingly requires ecologists to work with planners to address biodiversity challenges. Biodiversity conservation and enhancement is just one strand in urban planning, but is increasingly important in a rapidly urbanising world

Performance of missing transverse momentum reconstruction with the ATLAS detector using proton–proton collisions at √s = 13 TeV

The performance of the missing transverse momentum (EmissT) reconstruction with the ATLAS detector is evaluated using data collected in proton–proton collisions at the LHC at a centre-of-mass energy of 13 TeV in 2015. To reconstruct EmissT, fully calibrated electrons, muons, photons, hadronically decaying τ -leptons, and jets reconstructed from calorimeter energy deposits and charged-particle tracks are used. These are combined with the soft hadronic activity measured by reconstructed charged-particle tracks not associated with the hard objects. Possible double counting of contributions from reconstructed charged-particle tracks from the inner detector, energy deposits in the calorimeter, and reconstructed muons from the muon spectrometer is avoided by applying a signal ambiguity resolution procedure which rejects already used signals when combining the various EmissT contributions. The individual terms as well as the overall reconstructed EmissT are evaluated with various performance metrics for scale (linearity), resolution, and sensitivity to the data-taking conditions. The method developed to determine the systematic uncertainties of the EmissT scale and resolution is discussed. Results are shown based on the full 2015 data sample corresponding to an integrated luminosity of 3.2 fb−1