Relationship between moderate-to-vigorous physical activity, abdominal fat and immunometabolic markers in postmenopausal women

AbstractObjectsTo assess the burden of levels of physical activity, non-esterified fatty acids (NEFA), triacylglycerol and abdominal fat on the immunometabolic profile of postmenopausal women.Study designForty-nine postmenopausal women [mean age 59.43 (standard deviation 5.61) years] who did not undertake regular physical exercise participated in this study. Body composition was assessed using dual-energy X-ray absorptiometry, and levels of NEFA, tumour necrosis factor-α, adiponectin, insulin and triacylglycerol were assessed using fasting blood samples. The level of physical activity was assessed using an accelerometer (Actigraph GTX3x), and reported as counts/min, time spent undertaking sedentary activities and time spent undertaking moderate-to-vigorous physical activity (MVPA). The following conditions were considered to be risk factors: (i) sedentary lifestyle (<150min of MVPA per week); (ii) high level (above median) of abdominal fat; and (iii) hypertriacylglycerolaemia (<150mg/dl of triacylglycerol).ResultsIn comparison with active women, sedentary women had higher levels of body fat (%) (p=0.041) and NEFA (p=0.064). Women with higher levels of abdominal fat had impaired insulin resistance (HOMA-IR) (p=0.016) and spent more time undertaking sedentary activities (p=0.043). Moreover, the women with two risk factors or more had high levels of NEFA and HOMA-IR (p<0.05), as well as an eight-fold higher risk of a high level of NEFA, independent of age (p<0.05). No significant relationship was found between levels of physical activity, abdominal fat, tumour necrosis factor-α and adiponectin (p>0.05).ConclusionPostmenopausal women with a combination of hypertriacylglycerolaemia, a high level of abdominal fat and a sedentary lifestyle are more likely to have metabolic disturbances

Two years after molecular diagnosis of familial hypercholesterolemia: Majority on cholesterol-lowering treatment but a minority reaches treatment goal

Background: The risk of premature cardiovascular disease in patients with familial hypercholesterolemia (FH) can be profoundly reduced by cholesterol-lowering therapy, and current guidelines for FH advocate ambitious low-density lipoprotein cholesterol (LDL-C) goals. In the present study, we determined whether these goals are reflected in current clinical practice once FH has been diagnosed. Methodology/Principal Findings: In 2008, we sent questionnaires to all subjects (aged 18-65 years) who were molecularly diagnosed with FH in the year 2006 through the screening program in the Netherlands. Of these 1062 subjects, 781 completed the questionnaire (46% males; mean age: 42±12 years; mean LDL-C at molecular diagnosis (baseline): 4.1±1.3 mmol/L). The number of persons that used cholesterol-lowering therapy increased from 397 (51%) at baseline to 636 (81%) after diagnosis. Mean treated LDL-C levels decreased significantly to 3.2±1.1 mmol/L two years after diagnosis. Only 22% achieved the LDL-C target level of ≤2.5 mmol/L. Conclusions/Significance: The proportion of patients using cholesterol-lowering medication was significantly increased after FH diagnosis through

Optimized Trigger for Ultra-High-Energy Cosmic-Ray and Neutrino Observations with the Low Frequency Radio Array

When an ultra-high energy neutrino or cosmic ray strikes the Lunar surface a radio-frequency pulse is emitted. We plan to use the LOFAR radio telescope to detect these pulses. In this work we propose an efficient trigger implementation for LOFAR optimized for the observation of short radio pulses.Comment: Submitted to Nuclear Instruments and Methods in Physics Research Section

The heat is on:Investigating the effect of psychological pressure on competitive performance in elite surfing

Competitive sport often creates a high-stake and thus a high-pressure environment for its athletes. In the past, research has pointed to the negative effect that competitive pressure might have on skills and movement executions that have been perfected through prior practice. The Attentional Control Theory: Sport (ACTS) suggests that specifically high situational pressure and prior performance failures may negatively affect an athlete’s subsequent performance. This study aimed to investigate the influence of situational pressure and previous performance errors on performance (i.e., wave score) in elite surfing while considering various contextual factors. A total of 6497 actions, performed by 80 elite surfers (female n = 28; male n = 52), were annotated based on video recordings of the 2019 World Championship Tour (WCT). A multi-level model was used to analyse the effect of pressure, previous errors and other contextual factors on the wave scores of individual surfers (i.e., events were nested within athletes). Partially confirming previous research, prior errors caused a significant decrease in surfing performance on the following ride. However, neither a significant effect of situational pressure on performance nor inter-individual differences in how prior-errors and situational pressure affected performance were found.</p

Economische waarde van gekochte goodwill

Economische waardering van gekochte goodwil

Technical–tactical skill assessments in small-sided soccer games:A scoping review

Skill assessments are essential to elite soccer coaches and clubs, to provide an evidence-based approach to player evaluation. Valid methods thereby support talent identification and development procedures (e.g. scouting and training strategies). However, it remains a complex challenge. Small-sided games have emerged as a promising tool, due to high ecological validity. Until now, no review has focused on their discriminative power. Therefore, we aimed to investigate whether technical–tactical skill assessments of small-sided games can discriminate between individual players and between teams of different skill levels (i.e. higher vs. lower playing levels and older vs. younger players) in soccer. A scoping review of PubMed, Web of Science, and MEDLINE databases was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews guidelines. A total of 23 studies were included, all but one of which showed at least good methodological quality (i.e. > 50% score in quality assessment). For technical skills, small-sided games indicate discriminative power for passing skills, but only when comparing players of different playing levels, as supported by two of the included studies. Tactical categories, such as movement variability and decision-making, were more pronounced in higher level and more experienced players. However, the most conclusive finding among individual skill assessments was that the technical–tactical overall performance (a total score comprised of different subcategories) of individual players showed a positive relation to skill level in three studies. Team performance assessments in small-sided games showed that older and higher level teams mainly distinguish themselves from less-skilled peers by using the available space more efficiently. With the influence of different assessment instruments and several small-sided games modifications in mind, it may be concluded that technical–tactical skills in small-sided games can discriminate between players and teams of different skill levels. An interesting future avenue is to examine a more consistent approach to skill assessments in small-sided games, which can warrant their use for scouting and talent identification purposes