An interactive multimedia learning environment for VLSI built with COSMOS

This paper presents Bigger Bits, an interactive multimedia learning environment that teaches students about VLSI within the context of computer electronics. The system was built with COSMOS (Content Oriented semantic Modelling Overlay Scheme), which is a modelling scheme that we developed for enabling the semantic content of multimedia to be used within interactive systems

Identity studies: Multiple perspectives and implications for corporate-level marketing

Purpose – Provides a comprehensive review of the identity literature drawing on perspectives from marketing (corporate identity concept) and organisational behaviour (organisational identity) so as to provide an up-to –date overview of identity scholarship. Findings – Reveals a growing congruency between scholars of marketing and organisational behaviour in their comprehension of identity. Identifies four principal schools of thought relating to identity which differ in terms of conceptualisation, locus of analysis and explanandum (corporate identity, visual identity, an organisation’s identity and organisational identity). Our review confirms the importance of identity especially in relation to the concepts underpinning the nascent field of corporate-level marketing. Practical implications – the importance of taking a multidisciplinary perspective in the comprehension and management of identity in organisational contexts. Originality/Value – The first major review of identity studies that synthesises the marketing and organisational behaviour approaches to identity. Offers pointers in terms of the research agenda to be followed

Under pressure: pulmonary hypertension associated with left heart disease.

© ERS 2015.Pulmonary hypertension (PH) associated with left heart disease (PH-LHD) is the most common type of PH, but its natural history is not well understood. PH-LHD is diagnosed by right heart catheterisation with a mean pulmonary arterial pressure ⩾25 mmHg and a pulmonary capillary wedge pressure >15 mmHg. The primary causes of PH-LHD are left ventricular dysfunction of systolic and diastolic origin, and valvular disease. Prognosis is poor and survival rates are low. Limited progress has been made towards specific therapies for PH-LHD, and management focuses on addressing the underlying cause of the disease with supportive therapies, surgery and pharmacological treatments. Clinical trials of therapies for pulmonary arterial hypertension in patients with PH-LHD have thus far been limited and have provided disappointing or conflicting results. Robust, long-term clinical studies in appropriate target populations have the potential to improve the outlook for patients with PH-LHD. Herein, we discuss the knowledge gaps in our understanding of PH-LHD, and describe the current unmet needs and challenges that are faced by clinicians when identifying and managing patients with this disease

COSMOS-7: Video-oriented MPEG-7 scheme for modelling and filtering of semantic content

MPEG-7 prescribes a format for semantic content models for multimedia to ensure interoperability across a multitude of platforms and application domains. However, the standard leaves it open as to how the models should be used and how their content should be filtered. Filtering is a technique used to retrieve only content relevant to user requirements, thereby reducing the necessary content-sifting effort of the user. This paper proposes an MPEG-7 scheme that can be deployed for semantic content modelling and filtering of digital video. The proposed scheme, COSMOS-7, produces rich and multi-faceted semantic content models and supports a content-based filtering approach that only analyses content relating directly to the preferred content requirements of the user

Soluble trace metals in aerosols over the tropical south-east Pacific offshore of Peru

Bulk aerosol samples collected during cruise M91 of FS Meteor off the coast of Peru in December 2012 were analysed for their soluble trace metal (Fe, Al, Mn, Ti, Zn, V, Ni, Cu, Co, Cd, Pb, Th) and major ion (including NO3- and NH4+) content. These data are among the first recorded for trace metals in this relatively poorly studied region of the global marine atmosphere. To the north of ~13°S, the concentrations of several elements (Fe, Ti, Zn, V, Ni, Pb) appear to be related to distance from the coast. At the south of the transect (~15-16°S), elevated concentrations of Fe, Cu, Co and Ni were observed, and we calculated dry deposition fluxes of soluble Cu approximately an order of magnitude higher than a recent model-based estimate of total Cu deposition to the region. The model did not take account of emissions from the large smelting facilities in the south of Peru and northern Chile and our results may indicate that these facilities constitute an important source of trace metals to the region. Calculated dry deposition fluxes (3370-17800 and 16-107 nmol m-2 d-1 for inorganic nitrogen and soluble Fe respectively) indicated that atmospheric input to the waters of the Peru upwelling system contains an excess of Fe over N, with respect to phytoplankton requirements. This may be significant as primary production in these waters has been reported to be limited by Fe availability, but atmospheric deposition is unlikely to be the dominant source of Fe to the system

Enriching MPEG-7 user models with content metadata

MPEG-7 is an XML-based standard that provides tools for creating rich and structured multimedia content metadata. However, only an extremely limited range of preferences can be specified for user models and multimedia content metadata created by other parts of the standard cannot be fully exploited. This results in a very incomplete mapping of user models to content models. We present an approach to address the problem by representing user models by means of existing MPEG-7 content description tools

Descritpion of Exotic Nuclei Using Continuum Shell Model

In weakly bound exotic nuclei, number of excited bound states or narrow resonances is small and, moreover, they couple strongly to the particle continuum. Hence, these systems should be described in the quantum open system formalism which does not artificially separate the subspaces of (quasi-) bound and scattering states. The Shell Model Embedded in the Continuum provides a novel approach which solves this problem. Examples of application in sd-shell nuclei will be presented.Comment: Presented at the NATO Advanced Research Workshop Brijuni, Pula, Croatia, June 2-5, 200

Telomeres cluster de novo before the initiation of synapsis: a three-dimensional spatial analysis of telomere positions before and during meiotic prophase.

We have analyzed the progressive changes in the spatial distribution of telomeres during meiosis using three-dimensional, high resolution fluorescence microscopy. Fixed meiotic cells of maize (Zea mays L.) were subjected to in situ hybridization under conditions that preserved chromosome structure, allowing identification of stage-dependent changes in telomere arrangements. We found that nuclei at the last somatic prophase before meiosis exhibit a nonrandom, polarized chromosome organization resulting in a loose grouping of telomeres. Quantitative measurements on the spatial arrangements of telomeres revealed that, as cells passed through premeiotic interphase and into leptotene, there was an increase in the frequency of large telomere-to-telomere distances and a decrease in the bias toward peripheral localization of telomeres. By leptotene, there was no obvious evidence of telomere grouping, and the large, singular nucleolus was internally located, nearly concentric with the nucleus. At the end of leptotene, telomeres clustered de novo at the nuclear periphery, coincident with a displacement of the nucleolus to one side. The telomere cluster persisted throughout zygotene and into early pachytene. The nucleolus was adjacent to the cluster at zygotene. At the pachytene stage, telomeres rearranged again by dispersing throughout the nuclear periphery. The stage-dependent changes in telomere arrangements are suggestive of specific, active telomere-associated motility processes with meiotic functions. Thus, the formation of the cluster itself is an early event in the nuclear reorganizations associated with meiosis and may reflect a control point in the initiation of synapsis or crossing over

Entanglement generation outside a Schwarzschild black hole and the Hawking effect

We examine the Hawking effect by studying the asymptotic entanglement of two mutually independent two-level atoms placed at a fixed radial distance outside a Schwarzschild black hole in the framework of open quantum systems. We treat the two-atom system as an open quantum system in a bath of fluctuating quantized massless scalar fields in vacuum and calculate the concurrence, a measurement of entanglement, of the equilibrium state of the system at large times, for the Unruh, Hartle-Hawking and Boulware vacua respectively. We find, for all three vacuum cases, that the atoms turn out to be entangled even if they are initially in a separable state as long as the system is not placed right at the even horizon. Remarkably, only in the Unruh vacuum, will the asymptotic entanglement be affected by the backscattering of the thermal radiation off the space-time curvature. The effect of the back scatterings on the asymptotic entanglement cancels in the Hartle-Hawking vacuum case.Comment: 15 pages, no figures, Revte