Ultra-compact binaries: relevance and role of Utrecht

We present a short overview of the formation and evolution of ultra-compact binaries. They are relevant to a surprisingly large number of astrophysical phenomena (binary interactions, mass transfer stability, explosive phenomena such as type Ia supernovae and gravitational waves).Comment: To appear in proceedings of "370 years of astronomy in Utrecht", Noordwijkerhout, The Netherlands, April 2-5, 2012 (ASP Conference Series

A Gas-Fired Kiln For Home And Student Potters

45 leave

The Influence of Video Interaction Guidance on the Quality of Parental Bonding towards and Interaction with the Premature Infant

Developing a parent-infant bond and interaction can be more challenging for parents of a preterm born infant. This study wants to shed light on the influence of video interaction guidance (VIG) on the quality of parental bonding towards and interaction with the premature infant

Formation of the planet around the millisecond pulsar J1719-1438

Context. Recently the discovery of PSR J1719-1438, a 5.8 ms pulsar with a companion in a 2.2 hr orbit, was reported. The combination of this orbital period and the very low mass function is unique. The discoverers, Bailes et al., proposed an ultracompact X-ray binary (UCXB) as the progenitor system. However, the standard UCXB scenario would not produce this system as the time required to reach this orbital period exceeds the current estimate of the age of the Universe. The detached state of the system aggravates the problem. Aims. We want to understand the evolutionary history of PSR J1719-1438, and determine under which circumstances it could have evolved from an UCXB. Methods. We model UCXB evolution varying the donor size and investigate the effect of a wind mass loss from the donor, and compare the results with the observed characteristics of PSR J1719-1438. Results. An UCXB can reach a 2.2 hr orbit within the age of the Universe, provided that 1) the millisecond pulsar can significantly heat and expand the donor by pulsar irradiation, or 2) the system loses extra orbital angular momentum, e.g. via a fast wind from the donor. Conclusions. The most likely scenario for the formation of PSR J1719-1438 is UCXB evolution driven by angular momentum loss via the usual gravitational wave emission, which is enhanced by angular momentum loss via a donor wind of ~3x10^-13 Msun/yr. Depending on the size of the donor during the evolution, the companion presently probably has a mass of ~1-3 Jupiter masses, making it a very low mass white dwarf as proposed by Bailes et al. Its composition can be either helium or carbon-oxygen. A helium white dwarf companion makes the long (for an UCXB) orbital period easier to explain, but the required inclination makes it a priori less likely than a carbon-oxygen white dwarf.Comment: 5 pages, 4 figures. Accepted for publication in Astronomy and Astrophysics. v2: Updated a referenc

Population synthesis of classical low-mass X-ray binaries in the Galactic Bulge

Aims. We model the present-day population of 'classical' low-mass X-ray binaries (LMXBs) with neutron star accretors, which have hydrogen-rich donor stars. Their population is compared with that of hydrogen-deficient LMXBs, known as ultracompact X-ray binaries (UCXBs). We model the observable LMXB population and compare it to observations. Methods. We combine the binary population synthesis code SeBa with detailed LMXB evolutionary tracks to model the size and properties of the present-day LMXB population in the Galactic Bulge. Whether sources are persistent or transient, and what their instantaneous X-ray luminosities are, is predicted using the thermal-viscous disk instability model. Results. We find a population of ~2.1 x 10^3 LMXBs with neutron star accretors. Of these about 15 - 40 are expected to be persistent (depending on model assumptions), with luminosities higher than 10^35 erg s^-1. About 7 - 20 transient sources are expected to be in outburst at any given time. Within a factor of two these numbers are consistent with the observed population of bright LMXBs in the Bulge. This gives credence to our prediction of the existence of a population of ~1.6 x 10^3 LMXBs with low donor masses that have gone through the period minimum, and have present-day mass transfer rates below 10^-11 Msun yr^-1. Conclusions. Even though the observed population of hydrogen-rich LMXBs in the Bulge is larger than the observed population of (hydrogen-deficient) UCXBs, the latter have a higher formation rate. While UCXBs may dominate the total LMXB population at the present, the majority would be very faint, or may have become detached and produced millisecond radio pulsars. In that case UCXBs would contribute significantly more to the formation of millisecond radio pulsars than hydrogen-rich LMXBs. [abridged]Comment: 8 pages, 10 figures. Accepted for publication in Astronomy and Astrophysics. v2: minor language correction

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms

The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations can increase channel activity by multiple molecular mechanisms. In this study, we determined the mechanism by which KATP function is altered by several substitutions in distinct structural domains of SUR2: D207E in the intracellular L0-linker and Y985S, G989E, M1060I, and R1154Q/R1154W in TMD2. We engineered substitutions at their equivalent positions in rat SUR2A (D207E, Y981S, G985E, M1056I, and R1150Q/R1150W) and investigated functional consequences using macroscopic rubidium (86Rb-) efflux assays and patchclamp electrophysiology. Our results indicate that D207E increases KATP channel activity by increasing intrinsic stability of the open state, whereas the cluster of Y981S/G985E/M1056I substitutions, as well as R1150Q/R1150W, augmented Mg-nucleotide activation. We also tested the responses of these channel variants to inhibition by the sulfonylurea drug glibenclamide, a potential pharmacotherapy for CS. None of the D207E, Y981S, G985E, or M1056I substitutions had a significant effect on glibenclamide sensitivity. However, Gln and Trp substitution at Arg-1150 significantly decreased glibenclamide potency. In summary, these results provide additional confirmation that mutations in CS-Associated SUR2 mutations result in KATP gain-of-function. They help link CS genotypes to phenotypes and shed light on the underlying molecular mechanisms, including consequences for inhibitory drug sensitivity, insights that may inform the development of therapeutic approaches to manage CS

Constitutive behavior of as-cast A356

The constitutive behavior of aluminum alloy A356 in the as-cast condition has been characterized using compression tests performed over a wide range of deformation temperatures (30-500{\deg}C) and strain rates (\approx0.1-10 /s). This work is intended to support the development of process models for a wide range of conditions including those relevant to casting, forging and machining. The flow stress behavior as a function of temperature and strain rate has been fit to a modified Johnson-Cook and extended Ludwik-Hollomon expression. The data has also been assessed with both the strain-independent Kocks-Mecking and Zener-Hollomon frameworks. The predicted plastic flow stress for each expression are compared. The results indicate that the extended Ludwik-Hollomon is best suited to describe small strain conditions (stage III hardening), while the Kocks-Mecking is best employed for large strain (stage IV). At elevated temperatures, it was found that the Zener-Hollomon model provides the best prediction of flow stress.Comment: 34 pages, 12 figure

Time-resolved X-Shooter spectra and RXTE light curves of the ultra-compact X-ray binary candidate 4U 0614+091

In this paper we present X-Shooter time resolved spectroscopy and RXTE PCA light curves of the ultra-compact X-ray binary candidate 4U 0614+091. The X-Shooter data are compared to the GMOS data analyzed previously by Nelemans et al. (2004). We confirm the presence of C III and O II emission features at ~ 4650 {\AA} and ~ 5000 {\AA}. The emission lines do not show evident Doppler shifts that could be attributed to the motion of the donor star/hot spot around the center of mass of the binary. We note a weak periodic signal in the red-wing/blue-wing flux ratio of the emission feature at ~ 4650 {\AA}. The signal occurs at P = 30.23 +/- 0.03 min in the X-Shooter and at P = 30.468 +/- 0.006 min in the GMOS spectra when the source was in the low/hard state. Due to aliasing effects the period in the GMOS and X-Shooter data could well be the same. We deem it likely that the orbital period is thus close to 30 min, however, as several photometric periods have been reported for this source in the literature already, further confirmation of the 30 min period is warranted. We compare the surface area of the donor star and the disc of 4U 0614+091 with the surface area of the donor star and the disc in typical hydrogen-rich low-mass X-ray binaries and the class of AM Canum Venaticorum stars and argue that the optical emission in 4U 0614+091 is likely dominated by the disc emission. Additionally, we search for periodic signals in all the publicly available RXTE PCA light curves of 4U 0614+091 which could be associated with the orbital period of this source. A modulation at the orbital period with an amplitude of ~ 10% such as those that have been found in other ultra-compact X-ray binaries (4U 0513-40, 4U 1820-30) is not present in 4U 0614+091.Comment: Accepted for publication in MNRAS, 11 pages, 7 figure

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury

Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation and differentiation to restore biliary epithelial integrity. However, formal evidence for this concept in human livers is lacking. We, therefore, developed a novel ex vivo model using precision-cut slices of extrahepatic human bile ducts obtained from discarded donor livers, providing an intact anatomical organization of cell structures, to study spatiotemporal differentiation and migration of PBG cells after severe biliary injury. Post-ischemic bile duct slices were incubated in oxygenated culture medium for up to a week. At baseline, severe tissue injury was evident with loss of luminal epithelial lining and mural stroma necrosis. In contrast, PBG remained relatively well preserved and different reactions of PBG were noted, including PBG dilatation, cell proliferation and maturation. Proliferation of PBG cells increased after 24 h of oxygenated incubation, reaching a peak after 72 h. Proliferation of PBG cells was paralleled by a reduction in PBG apoptosis and differentiation from a primitive and pluripotent (Nanog+/Sox9+) to a mature (CFTR+/secretin receptor+) and activated phenotype (increased expression of HIF-1α, Glut-1, and VEGF-A). Migration of proliferating PBG cells in our ex vivo model was unorganized, but resulted in generation of epithelial monolayers at stromal surfaces. CONCLUSION: Human PBG contain biliary progenitor cells and are able to respond to bile duct epithelial loss with proliferation, differentiation, and maturation to restore epithelial integrity. The ex vivo spatiotemporal behaviour of human PBG cells provides evidence for a pivotal role of PBG in biliary regeneration after severe injury. This article is protected by copyright. All rights reserved