Blood dynamics of mercury and selenium in northern elephant seals during the lactation period

The effects of reproduction and maternal investment (i.e., milk transfer) on trace element levels remain poorly understood in marine mammals. We examined the blood dynamics of mercury (Hg) and selenium (Se) during lactation in the northern elephant seal (Mirounga angustirostris), a top predator from the North Pacific Ocean. Total Hg and Se levels were measured in whole blood and milk of 10 mother-pup pairs on days 5 and 22 of lactation. Both Hg and Se were transferred to offspring through the milk. Results suggested that the maternal transfer of Se was prominent during lactation, whereas the Hg transfer was larger during gestation. The lactation period affected Hg and Se levels in the blood of elephant seal mothers and pups. Physiological processes and their relationship to body condition should be considered carefully when interpreting trace element levels in the framework of biomonitoring.Peer reviewe

The Nations Within / Les Nations dans la nation

La journée d’étude The Nations Within / Les Nations dans la nation, organisée à l’Université Paris 7 - Diderot le vendredi 15 novembre 2013 à l’initiative de Marine Le Puloch (Paris 7) et Céline Planchou (Paris 13), a proposé aux intervenants de s’interroger sur le statut des nations autochtones aux Etats-Unis, tant en termes juridiques qu’identitaires, depuis les fondements de la Jeune République jusqu’à aujourd’hui. Cette journée se proposait d’explorer plusieurs questions. Quelle place occ..

MISTRAL: sistema de recuperação documentária

O Sistema de recuperação documentária, MISTRAL, é um sistema integrado de documentação automatizado, que inclui: busca retrospectiva, disseminação seletiva da informação, entrada em linha de documentos, indexação automática, gestão de léxico e tesauros, interface para videodisco, máquinas de microfilmagem e de fotocomposição. Permite a organização dos maiores bancos de dados na Europa e no mundo.

The Nations Within / Les Nations dans la nation

La journée d’étude The Nations Within / Les Nations dans la nation, organisée à l’Université Paris 7 - Diderot le vendredi 15 novembre 2013 à l’initiative de Marine Le Puloch (Paris 7) et Céline Planchou (Paris 13), a proposé aux intervenants de s’interroger sur le statut des nations autochtones aux Etats-Unis, tant en termes juridiques qu’identitaires, depuis les fondements de la Jeune République jusqu’à aujourd’hui. Cette journée se proposait d’explorer plusieurs questions. Quelle place occ..

The Nations Within / Les Nations dans la nation

La journée d’étude The Nations Within / Les Nations dans la nation, organisée à l’Université Paris 7 - Diderot le vendredi 15 novembre 2013 à l’initiative de Marine Le Puloch (Paris 7) et Céline Planchou (Paris 13), a proposé aux intervenants de s’interroger sur le statut des nations autochtones aux Etats-Unis, tant en termes juridiques qu’identitaires, depuis les fondements de la Jeune République jusqu’à aujourd’hui. Cette journée se proposait d’explorer plusieurs questions. Quelle place occ..

The Varicella-Zoster Virus Immediate-Early 63 protein affects chromatin controlled gene transcription in a cell-type dependent manner

Varicella Zoster Virus Immediate Early 63 protein (IE63) has been shown to be essential for VZV replication, and critical for latency establishment. The activity of the protein as a transcriptional regulator is not fully clear yet. Using transient transfection assays, IE63 has been shown to repress viral and cellular promoters containing typical TATA boxes by interacting with general transcription factors. In this paper, IE63 regulation properties on endogenous gene expression were evaluated using an oligonucleotide-based micro-array approach. We found that IE63 modulates the transcription of only a few genes in HeLa cells including genes implicated in transcription or immunity. Furthermore, we showed that this effect is mediated by a modification of RNA POL II binding on the promoters tested and that IE63 phosphorylation was essential for these effects. In MeWo cells, the number of genes whose transcription was modified by IE63 was somewhat higher, including genes implicated in signal transduction, transcription, immunity, and heat-shock signalling. While IE63 did not modify the basal expression of several NF-κB dependent genes such as IL-8, ICAM-1, and IκBα, it modulates transcription of these genes upon TNFα induction. This effect was obviously correlated with the amount of p65 binding to the promoter of these genes and with histone H3 acetylation and HDAC-3 removal. Conclusion While IE63 only affected transcription of a small number of cellular genes, it interfered with the TNF-inducibility of several NF-κB dependent genes by the accelerated resynthesis of the inhibitor IκBα

Mathematical modeling of extracorporeal CO2 removal

Extra¬cor¬poreal CO2 removal devices (ECCO2R) can be used in clinics to decarboxylate blood externally for patients suffering from pulmonary insufficiencies like acute respiratory distress syndrome. In this work, a model of the respiratory system coupled with such a device is proposed to analyze the decrease of CO2 partial pressure in blood as a function of blood flow through the device. This model provides a mathematical tool which could help clinicians to choose the optimal settings of ECCO2R.Mathematical modeling and optimization of the use of cardiopulmonary assistances in intensive care unit