The Relationship Between Function and Disease Activity as Measured by the HAQ and DAS28 Varies Over Time and by Rheumatoid Factor Status in Early Inflammatory Arthritis (EIA). Results from the CATCH Cohort§

Objective: To investigate the relationship between function and disease activity in early inflammatory arthritis (EIA). Methods: Canadian Early Arthritis Cohort (CATCH) (n=1143) is a multi-site EIA cohort. Correlations between the Health Assessment Questionnaire Disability Index (HAQ) and DAS28 were done at every 3 months for the first year and then at 18 and 24 months. We also investigated the relationship between HAQ and DAS28 by age (<65 versus ≥65) and RF (positive vs negative). Results: Mean HAQ and DAS28 scores were highest at the initial visit with HAQ decreasing over 24 months from a baseline of 0.94 to 0.40 and DAS28 scores decreasing from 4.54 to 2.29. All correlations between HAQ and DAS28 were significant at all time points (p<0.01). The correlations between HAQ and DAS28 were variable over time. The strongest correlation between HAQ and DAS28 occurred at initial visit (most DMARD naive) (n=1,143) and 18 months (r=0.57, n=321) and 24 months (r=0.59, n=214). The baseline correlation between HAQ and DAS28 was significantly different than correlations obtained at 3, 6, and 12 months (p=0.02, 0.01, and 0.01, respectively). Age did not change the association between HAQ and DAS28 {<65 years old (r=0.50, n=868) versus ≥65 (r=0.48, n=254), p=0.49}. The correlation between HAQ and DAS28 was stronger with RF+ patients (r=0.63, n=636) vs RF negative (r=0.47, n=477), p=0.0043 Conclusion: Over 2 years in EIA, HAQ and DAS both improved; correlations at time points were different over 2 years and RF status affected the correlations

Cost-effectiveness modeling of abatacept versus other biologic agents in DMARDS and anti-TNF inadequate responders for the management of moderate to severe rheumatoid arthritis

To assess the cost-effectiveness of abatacept compared to different biologic treatment strategies for moderate to severe rheumatoid arthritis based on current medical practices in Canada. A model was constructed to assess the cost-effectiveness of various biologic treatments over a 2-year time horizon, using two effectiveness endpoints: "low disease activity state” (LDAS) and "remission”. Abatacept, as first biologic agent after an inadequate response to DMARDs, provides greater treatment success rate for achieving LDAS (29.4% versus 15.6%) and remission (14.8% versus 5.2%), and appears significantly more cost-effective compared to the sequential use of anti-TNF agents (p < 0.001). Abatacept, as second biologic agent after an inadequate response to one anti-TNF agent, provides greater treatment success rate for achieving LDAS (17.1% versus 10.2%) and remission (7.4% versus 3.9%) and appears significantly more cost-effective compared to the sequential use of anti-TNF agents (p < 0.001). Abatacept is a cost-effective strategy in patients with an inadequate response to DMARDs or to one anti-TNF agen

Analysis of the impact of the behavior of front-office employee, trust and satisfaction on the customer loyalty of bank customers

The front-office employee is an important source of customer loyalty, which contributes to the competitive superiority of the bank, since it is always in direct contact with the customer. Thus, their behavior is essential to maintain this relationship. The main objective of this article is to study the impact of the behavior of front-office employee, satisfaction and trust in the customer loyalty of bank customers. The analysis of the results confirmed the existence of a significant relationship between the different variables on the loyalty of bank customers.The front-office employee is an important source of customer loyalty, which contributes to the competitive superiority of the bank, since it is always in direct contact with the customer. Thus, their behavior is essential to maintain this relationship. The main objective of this article is to study the impact of the behavior of front-office employee, satisfaction and trust in the customer loyalty of bank customers. The analysis of the results confirmed the existence of a significant relationship between the different variables on the loyalty of bank customers

L’impact du Brand Content sur l'engagement dans les Réseaux sociaux « Cas des pages Facebook des Organisations non gouvernementales (ONG)/associations à but non lucratif »

This study, which is part of a digital marketing strategy, proposes and empirically tests a model that identifies the key factors related to the characteristics of NGO content and influences the engagement of Internet users, is presented by explanatory variables related to the context of the content and the dependent variable representing the engagement indicator. To guide our understanding of how NGOs use brand content to increase engagement in Facebook. Our study uses a questionnaire response analysis method to test the research model, and we choose the regression model as the hypothesis testing technique.Cette étude, qui fait partie d'une stratégie de marketing numérique, propose et teste empiriquement un modèle qui identifie les facteurs clés liés aux caractéristiques du contenu des organisations non gouvernementales (ONG) et influence l'engagement des internautes, est présentée par des variables explicatives liées au contexte du contenu et la variable dépendante représentant l’indicateur de l'engagement. Pour guider notre compréhension de la façon dont les ONG utilisent le brand content pour augmenter l'engagement dans Facebook. Notre étude utilise une méthode d'analyse des réponses au questionnaire pour tester le modèle de recherche, et nous choisissons le modèle de régression comme technique de test d'hypothèse

LA CONFIANCE DU CONSOMMATEUR DANS LE E-COMMERCE : CAS DE JUMIA.MA

La confiance est une composante essentielle dans la gestion du e-commerce. Elle peut transformer une simple relation d’échange à court terme en une relation plus solide à long terme. Dans le e-commerce, la confiance a pris un rôle important, devenant une variable essentielle dans le processus d’achat et celui de prise de décisions. Elle a un impact assez considérable et direct sur le comportement d’achat du consommateur en ligne.En fait, la confiance est un concept qui a suscité l’intérêt des chercheurs vis-à-vis de sa mesure et les stratégies qui incitent à la développer, pour appliquer les connaissances acquises dans des mécanismes spécifiques de gestion. L’objectif de cet article est d’essayer d’évaluer et de mesurer la confiance perçue par les consommateurs envers Jumia.ma, qui représente un e-commerce africain établi au Maroc depuis quatre ans, l’un des sites les plus visités dans le pays, et qui peut constituer un des meilleurs cas pratique

Exploration de l'Impact du Comportement du Personnel en Contact sur la Fidélité de la Clientèle Bancaire : Modélisation par les équations structurelles

The role of the front-office employee is of paramount importance in the relational fabric that underpins customer loyalty, a variable of considerable significance in the edifice of competitive banking supremacy. Because of its direct and constant interaction with customers, this segment of the workforce assumes a strategic position within this dynamic. Indeed, the interactions between front-line staff and customers are of a substantial nature, being the epicenter where perceptions and experiences converge, thus having a considerable impact on the sustainability and enrichment of the banking relationship. The intrinsic behavior of the front-office employee is a key element in the relational architecture that maintains and enhances the customer-bank bond. In this respect, the decisive nature of the behavior in question requires in-depth exploration in order to decipher its underlying implications. Consequently, the primary essence of the present research lies in the methodical examination of the influence exerted by the behavior of the front-office employee on bank customer loyalty, an influence mediated by the crucial dimension of trust that is established between the parties. The main objective, therefore, is to examine, analyze and unravel the interstitial links between contact personnel behavior and customer loyalty, while reflecting on the catalytic intermediary that is trust. The conceptual framework within which this investigation operates encompasses elements of social psychology, behavioral economics and management science, thus building a multidisciplinary foundation that lends a holistic dimension to the analysis in question. The results of this investigation support and illuminate the conceptual framework developed earlier. The emerging data, following a series of rigorous analytical approaches, confirm the existence of an intrinsic and substantial relationship between the different variables explored, in this case, the front-office employee behavior and bank customer loyalty. &nbsp; Keywords: Behavior of front-office employee, banking sector, customer loyalty, trust.JEL Classification: G29, M31, M51 Paper type: Empirical researchLe rôle du personnel en contact revêt une importance capitale dans le tissu relationnel qui sous-tend la fidélité du client, une variable d'une portée non négligeable dans l'édifice de la suprématie concurrentielle bancaire. Ce segment du personnel, du fait de son interaction directe et constante avec la clientèle, assume une position stratégique au sein de cette dynamique. En effet, les interactions entre le personnel en contact et les clients revêtent une nature substantielle, étant l'épicentre où convergent les perceptions et les expériences, induisant ainsi un impact considérable sur la durabilité et l'enrichissement de la relation bancaire. Le comportement intrinsèque du personnel en contact se manifeste comme une pièce maîtresse dans l'architecture relationnelle qui engendre le maintien et l'élévation des liens client-banque. À cet égard, le caractère déterminant du comportement en question exige une exploration approfondie afin de décrypter ses implications sous-jacentes. Par conséquent, l'essence première de la présente recherche réside dans l'examen méthodique de l'influence exercée par le comportement du personnel en contact sur la fidélité de la clientèle bancaire, une influence médiée par la dimension cruciale de la confiance qui s'établit entre les parties. L'objectif principal, donc, est de scruter, analyser et démêler les liens interstitiels entre le comportement du personnel en contact et la fidélité du client, tout en méditant sur l'intermédiaire catalyseur qu'est la confiance. Le cadre conceptuel au sein duquel cette investigation opère englobe les éléments de la psychologie sociale, de l'économie comportementale et des sciences de gestion, érigeant ainsi un socle multidisciplinaire qui confère une dimension holistique à l'analyse en question. Les résultats de cette investigation soutiennent et éclairent la trame conceptuelle élaborée précédemment. Les données émergentes, après une série de démarches analytiques rigoureuses, consacrent l'existence d'une relation intrinsèque et substantielle entre les différentes variables explorées, en l'occurrence, le comportement du personnel en contact et la fidélité des clients bancaires. &nbsp; Mots clés&nbsp;: Comportement de l’employé en interaction, secteur bancaire, Confiance, fidélité des clients bancaire. Classification JEL : G29, M31, M51 Type de l’article&nbsp;: Recherche appliqué