Hippophae rhamnoides L. (sea buckthorn) mediated green synthesis of copper nanoparticles and their application in anticancer activity

Green synthesis of nanoparticles has drawn huge attention in the last decade due to their eco-friendly, biocompatible nature. Phyto-assisted synthesis of metallic nanoparticles is widespread in the field of nanomedicine, especially for antimicrobial and anticancer activity. Here in the present research work, investigators have used the stem extract of the Himalayan plant Hippophae rhamnoides L, for the synthesis of copper nanoparticles (CuNPs). The synthesized of CuNPs were analyzed by using sophisticated instruments, i.e., Fourier transform infrared spectroscopy (FTIR), UV-Vis spectroscopy, X-ray diffraction (XRD), high-performance liquid chromatography (HPLC), and scanning electron microscope (SEM). The size of the synthesized CuNPs was varying from 38 nm to 94 nm which were mainly spherical in shape. Further, the potential of the synthesized CuNPs was evaluated as an anticancer agent on the Hela cell lines, by performing an MTT assay. In the MTT assay, a concentration-dependent activity of CuNPs demonstrated the lower cell viability at 100 μg/mL and IC50 value at 48 μg/mL of HeLa cancer cell lines. In addition to this, apoptosis activity was evaluated by reactive oxygen species (ROS), DAPI (4′,6-diamidino-2-phenylindole) staining, Annexin V, and Propidium iodide (PI) staining, wherein the maximum ROS production was at a dose of 100 µg per mL of CuNPs with a higher intensity of green fluorescence. In both DAPI and PI staining, maximum nuclear condensation was observed with 100 μg/mL of CuNPs against HeLa cell lines

Dermo-Cosmetic Benefits of Marine Macroalgae-Derived Phenolic Compounds

Marine macroalgae have an interesting profile of bioactive compounds and have gained tremendous attention in cosmeceuticals with negligible toxicity effects (cytotoxicity, reproductive toxicity, genotoxicity, mutagenicity, carcinogenicity, etc.) on humans and exhibit strong benefits for the skin. Among the diversified compounds, phenolic compounds are the group of phytochemicals found in high amounts with great structural diversity. Phlorotannin is the most studied polyphenol compound in brown algae, but besides there are some other phenolic compounds observed and studied in macroalgae such as terpenoids, bromophenols, mycosporine amino acids (MAAs), and flavonoids. These compounds are already characterized and studied for their full range of cosmeceutical benefits such as skin whitening, moisturizing, photoprotection, antiaging, antiwrinkle, anti-melanogenic, and antioxidant activities as well as in the treatment of pruritus (caused by acne, eczema, dermatitis, hives, psoriasis), photoaging, and skin pigmentation disorders (hypopigmentation due to the absence of melanocytes and hyperpigmentation caused by skin irritation or metabolic disorders). This review study mainly focuses on marine algae-derived phenolic compounds and their extraction, characterization, and skin cosmetic benefits described in the literature. The present study aims to provide a detailed insight into the phenolic compounds in marine algae

Phycochemical Characterization of Marine macroalgae, Sargassum tenerrimum Collected from Beyt Dwarka, Western Coast of Gujarat, India

Industries are moving towards finding a natural source of functionally active constituents which is better and safer materials to fulfill customers’ demand. Marine algae contain a huge variety of biologically active compounds and express a promising role in different applications. Hence, the present study was carried out to characterize different biochemicals from brown alga Sargassum tenerrimum by FTIR, GCMS, HRLCMS Q-TOF, and ICP AES technique. First, the macroalga was collected from the Beyt Dwarka sea site, the Western coast of Gujarat, India. In FTIR, different types of bioactive functional groups were characterized as accountable for different beneficial components whereas ethanolic and methanolic extracts of S. tenerrimum reported fourteen and nineteen different beneficial phycocompounds in GCMS analysis, respectively. In HRLCMS Q-TOF analysis, two compounds were found carbohydrate derivatives and fifty-nine different compounds were determined to be different types of phycocompounds. Additionally, in the ICP AES study, Silicon was found to be high up in amount whereas Copper remained the minimum among studied elements. Moreover, the HRLCMS-QTOF study of amino acids reported that Glutamic acid (132.13 nmol/mL) was found to be the highest whereas Isoleucine (0.70 nmol/mL) was found to be the least amidst measured twenty-one amino acids. Bioactive potentials of these compounds have been reported in many previous studies. The inclusion of macroalgae-derived constituents in different applications has been broadly rising due to their bioactive potentials.</jats:p

Pioneering Role of Marine Macroalgae in Cosmeceuticals

Cosmetics are broadly used by people to protect the skin from external environmental stresses and for beauty purposes globally. A recent trend towards cosmetics with natural formulations has emerged. The cosmetic industry uses the term ‘cosmeceutical’ to refer to a cosmetic formula that has drug-like applicative advantages. Recently, macroalgae have received increased attention as natural ingredients for cosmeceutical applications. Many marine algae are rich in biologically active components that have been reported to exhibit strong benefits to the skin, mainly for photoprotection, skin whitening, moisturization, anti-aging, anti-wrinkle, antioxidants, and antimicrobial uses. The present review provides a detailed study of the literature on the cosmetic potentials of marine algae-derived polysaccharides, peptides and amino acids, pigments, phenolic components, and fatty acids. We provide an overview of different types of macroalgae with their biologically active constituents and potential cosmetic benefits. In addition, the bioactive molecules of cosmetic products containing marine macroalgae as well as their mechanisms of action are briefly discussed.</jats:p

Pioneering Role of Marine Macroalgae in Cosmeceuticals

Cosmetics are broadly used by people to protect the skin from external environmental stresses and for beauty purposes globally. A recent trend towards cosmetics with natural formulations has emerged. The cosmetic industry uses the term &lsquo;cosmeceutical&rsquo; to refer to a cosmetic formula that has drug-like applicative advantages. Recently, macroalgae have received increased attention as natural ingredients for cosmeceutical applications. Many marine algae are rich in biologically active components that have been reported to exhibit strong benefits to the skin, mainly for photoprotection, skin whitening, moisturization, anti-aging, anti-wrinkle, antioxidants, and antimicrobial uses. The present review provides a detailed study of the literature on the cosmetic potentials of marine algae-derived polysaccharides, peptides and amino acids, pigments, phenolic components, and fatty acids. We provide an overview of different types of macroalgae with their biologically active constituents and potential cosmetic benefits. In addition, the bioactive molecules of cosmetic products containing marine macroalgae as well as their mechanisms of action are briefly discussed

Comprehensive Phytochemical Analysis and Bioactivity Evaluation of Padina boergesenii: Unveiling Its Prospects as a Promising Cosmetic Component

Marine macroalgae, such as Padina boergesenii, are gaining recognition in the cosmetics industry as valuable sources of natural bioactive compounds. This study aimed to investigate the biochemical profile of P. boergesenii and evaluate its potential as a cosmetic ingredient. Fourier-transform infrared (FTIR), gas chromatography-mass spectrometry (GCMS), and high-resolution liquid chromatography-mass spectrometry quadrupole time-of-flight (HRLCMS QTOF) analyses were employed to assess the functional groups, phycocompounds, and beneficial compounds present in P. boergesenii. Pigment estimation, total phenol and protein content determination, DPPH antioxidant analysis, and tyrosinase inhibition assay were conducted to evaluate the extracts' ability to counteract oxidative stress and address hyperpigmentation concerns. Elemental composition and amino acid quantification were determined using inductively coupled plasma atomic emission spectrometry (ICP-AES) and HRLCMS, respectively. FTIR spectroscopy confirmed diverse functional groups, including halo compounds, alcohols, esters, amines, and acids. GCMS analysis identified moisturizing, conditioning, and anti-aging compounds such as long-chain fatty alcohols, fatty esters, fatty acids, and hydrocarbon derivatives. HRLCMS QTOF analysis revealed phenolic compounds, fatty acid derivatives, peptides, terpenoids, and amino acids with antioxidant, anti-inflammatory, and skin-nourishing properties. Elemental analysis indicated varying concentrations of elements, with silicon (Si) being the most abundant and copper (Cu) being the least abundant. The total phenol content was 86.50 µg/mL, suggesting the presence of antioxidants. The total protein content was 113.72 µg/mL, indicating nourishing and rejuvenating effects. The ethanolic extract exhibited an IC50 value of 36.75 μg/mL in the DPPH assay, indicating significant antioxidant activity. The methanolic extract showed an IC50 value of 42.784 μg/mL. Furthermore, P. boergesenii extracts demonstrated 62.14% inhibition of tyrosinase activity. This comprehensive analysis underscores the potential of P. boergesenii as an effective cosmetic ingredient for enhancing skin health. Given the increasing use of seaweed-based bioactive components in cosmetics, further exploration of P. boergesenii's potential in the cosmetics industry is warranted to leverage its valuable properties

Cosmeceutical Significance of Seaweed: A Focus on Carbohydrates and Peptides in Skin Applications

The term ‘cosmeceutical’ refers to cosmetic products that offer medicinal or drug-like benefits. Marine algae are rich sources of bioactive compounds, particularly carbohydrates and peptides, which have gained attention for their potential in cosmeceuticals. These compounds are abundant, safe, and have minimal cytotoxicity effects. They offer various benefits to the skin, including addressing rashes, pigmentation, aging, and cancer. Additionally, they exhibit properties such as antimicrobial, skin-whitening, anti-aging, antioxidant, and anti-melanogenic effects. This review surveys the literature on the cosmeceutical potentials of algae-derived compounds, focusing on their roles in skin whitening, anti-aging, anticancer, antioxidant, anti-inflammatory, and antimicrobial applications. The discussion also includes current challenges and future opportunities for using algae for cosmeceutical purposes