Leptogenesis, Gravitino Dark Matter and Entropy Production

Many extensions of the Standard Model predict super-weakly interacting particles, which typically have to decay before Big Bang Nucleosynthesis (BBN). The entropy produced in the decays may help to reconcile thermal leptogenesis and BBN in scenarios with gravitino dark matter, which is usually difficult due to late decays of the next-to-lightest supersymmetric particle (NLSP) spoiling the predictions of BBN. We study this possibility for a general neutralino NLSP. We elaborate general properties of the scenario and strong constraints on the entropy-producing particle. As an example, we consider the saxion from the axion multiplet and show that, while enabling a solution of the strong CP problem, it can also produce a suitable amount of entropy.Comment: 28 pages, 3 figures; v2: references updated, changes in presentation including some generalization, results and conclusions unchanged; v3: 1 reference added, matches published versio

Effects of meditation experience on functional connectivity of distributed brain networks

This study sought to examine the effect of meditation experience on brain networks underlying cognitive actions employed during contemplative practice. In a previous study, we proposed a basic model of naturalistic cognitive fluctuations that occur during the practice of focused attention meditation. This model specifies four intervals in a cognitive cycle: mind wandering (MW), awareness of MW, shifting of attention, and sustained attention. Using subjective input from experienced practitioners during meditation, we identified activity in salience network regions during awareness of MW and executive network regions during shifting and sustained attention. Brain regions associated with the default mode were active during MW. In the present study, we reasoned that repeated activation of attentional brain networks over years of practice may induce lasting functional connectivity changes within relevant circuits. To investigate this possibility, we created seeds representing the networks that were active during the four phases of the earlier study, and examined functional connectivity during the resting state in the same participants. Connectivity maps were then contrasted between participants with high vs. low meditation experience. Participants with more meditation experience exhibited increased connectivity within attentional networks, as well as between attentional regions and medial frontal regions. These neural relationships may be involved in the development of cognitive skills, such as maintaining attention and disengaging from distraction, that are often reported with meditation practice. Furthermore, because altered connectivity of brain regions in experienced meditators was observed in a non-meditative (resting) state, this may represent a transference of cognitive abilities “off the cushion” into daily life

A new life for sterile neutrinos: resolving inconsistencies using hot dark matter

Within the standard LCDM model of cosmology, the recent Planck measurements have shown discrepancies with other observations, e.g., measurements of the current expansion rate H_0, the galaxy shear power spectrum and counts of galaxy clusters. We show that if LCDM is extended by a hot dark matter component, which could be interpreted as a sterile neutrino, the data sets can be combined consistently. A combination of Planck data, WMAP-9 polarisation data, measurements of the BAO scale, the HST measurement of H_0, Planck galaxy cluster counts and galaxy shear data from the CFHTLens survey yields Delta N_eff = 0.61 pm 0.30 and m_s^eff = (0.41 pm 0.13) eV at 1 sigma. The former is driven mainly by the large H_0 of the HST measurement, while the latter is driven by cluster data. CFHTLens galaxy shear data prefer Delta N_eff >0 and a non-zero mass. Taken together, we find hints for the presence of a hot dark matter component at 3 sigma. A sterile neutrino motivated by the reactor and gallium anomalies appears rejected at even higher significance and an accelerator anomaly sterile neutrino is found in tension at 2 sigma.Comment: 11 pages, 2 figures; v2: 12 pages, 3 figures, references added and discussion slightly expanded, matches version published in JCA

Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum.

BACKGROUND: Several electroporation protocols exist to transfect exogenous DNA into Plasmodium falciparum. To date, however, only a subjective analysis of their relative efficiencies has been reported. METHODS: A time-course of luciferase reporter expression is used to provide an objective quantitative analysis of the absolute efficiency of three electroporation techniques; direct electroporation of ring stage infected erythrocytes, preloading of erythrocytes and a novel "double-tap" protocol that combines both approaches. RESULTS: Preloading of erythrocytes shows a mean efficiency of 9.59 x 10(-6), some 5-180 fold more efficient than matched experiments utilizing the "double-tap" and direct electroporation of ring stage infected erythrocytes alone, respectively. CONCLUSION: Evidence presented here provides the first quantitative assessment of both the absolute and relative efficiencies of a key molecular tool used to study the biology and pathogenesis of this important human pathogen

Evaluation of bioluminescence-based assays of anti-malarial drug activity

Transgenic Plasmodium falciparum expressing luciferase offers an attractive bioluminescence-based assay platform for the investigation of the pharmacological properties of anti-malarial drugs. Here a side-by-side comparison of bioluminescence and fluorescence-based assays, utilizing a luciferase reporter cassette that confers a strong temporal pattern of luciferase expression during the S-phase of intraerythrocytic development, is reported

Testing Superstring Theories with Gravitational Waves

We provide a simple transfer function that determines the effect of an early matter dominated era on the gravitational wave background and show that a large class of compactifications of superstring theory might be tested by observations of the gravitational wave background from inflation. For large enough reheating temperatures > 10^9 \GeV the test applies to all models containing at least one scalar with mass < 10^{12}\GeV that acquires a large initial oscillation amplitude after inflation and has only gravitational interaction strength, i.e., a field with the typical properties of a modulus.Comment: 5 pages 2 figures, v2: changes in presentation, refs revised, matches version in print in PR

Dark and visible matter with broken R-parity and the axion multiplet

A small breaking of R-parity reconciles thermal leptogenesis, gravitino dark matter and primordial nucleosynthesis. We find that the same breaking relaxes cosmological bounds on the axion multiplet. Naturally expected spectra become allowed and bounds from late particle decays become so weak that they are superseded by bounds from non-thermal axion production. In this sense, the strong CP problem serves as an additional motivation for broken R-parity.Comment: 13 pages + refs, 1 table, v2: refs added, minor changes in presentation, v3: refs added, added discussion of decays into Higgs and Higgsino, matches published versio