The INCF Digital Atlasing Program: Report on Digital Atlasing Standards in the Rodent Brain

The goal of the INCF Digital Atlasing Program is to provide the vision and direction necessary to make the rapidly growing collection of multidimensional data of the rodent brain (images, gene expression, etc.) widely accessible and usable to the international research community. This Digital Brain Atlasing Standards Task Force was formed in May 2008 to investigate the state of rodent brain digital atlasing, and formulate standards, guidelines, and policy recommendations.

Our first objective has been the preparation of a detailed document that includes the vision and specific description of an infrastructure, systems and methods capable of serving the scientific goals of the community, as well as practical issues for achieving
the goals. This report builds on the 1st INCF Workshop on Mouse and Rat Brain Digital Atlasing Systems (Boline et al., 2007, _Nature Preceedings_, doi:10.1038/npre.2007.1046.1) and includes a more detailed analysis of both the current state and desired state of digital atlasing along with specific recommendations for achieving these goals

頂点作用素超代数の最小共形重み空間の共形デザインについて

Tohoku University島倉裕樹課

Temporary exclusion of ill children from childcare centres in Switzerland: practice, problems and potential solutions.

BACKGROUND: In childcare centres, temporary exclusion of ill children, if their illness poses a risk of spread of harmful diseases to others, is a central approach to fight disease transmission. However, not all ill children need to be excluded. Previous studies suggested that childcare centre staff have difficulties in deciding whether or not to exclude an ill child, even when official ill-child guidelines are used. We aimed to describe, quantify and analyse these ambiguities and discuss potential solutions. METHODS: For this cross-sectional study, we sent postal surveys to 488 childcare centre directors in the Swiss Canton of Zurich, where no official ill-child guideline is in place. We asked for exclusion criteria for ill children and ambiguities faced when dealing with ill children. We checked whether existing guidelines provided solutions to the ambiguities identified. RESULTS: 249/488 (51%) directors responded to the survey. The most common exclusion criteria were fever (87.4%) and contagiousness (52.2%). Ambiguities were mostly caused by conjunctivitis (23.7%) and use of antipyretic drugs (22.9%). Roughly one third of the ambiguities identified could have been resolved with existing guidelines, another third if existing guidelines contained additional information. For the last third, clear written directives are difficult to formulate. CONCLUSIONS: Written recommendations may help to clarify when an ill child should temporarily be excluded. However, such a guideline should cover the topics antipyretic drugs and teething and have room for modification to local circumstances. Collaboration with a paediatrician may be of additional benefit

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.A.T. was supported by the research funding for longevity sciences (23-39) from National Center for Geriatrics and Gerontology, and the Strategic Research Programme for Brain Science ('Integrated Research on Neuropsychiatric Disorders') and Grant in Aid for Scientific Research on Innovative Areas ('Brain Environment') from the Ministry of Education, Science, Sports and Culture of Japan. K.C., D.J.W. and G.L.C. were supported by UK Wellcome Trust-MRC Neurodegenerative Disease Initiative Programme. K.C. was supported by the Korea-UK Alzheimer's Disease Research Consortium programme from the Ministry of Health and Welfare (Korea). G.L.C. was supported by the WCU Programme (Korea). I.S. was supported by the British Council. The collaboration between K.C. and A.T. was supported by a Sasakawa Foundation grant awarded to K.C. K.C. was supported by the Wolfson Research Merit Award and the Royal Society, London

The dawn of a new era in surgery for lymphedema

departmental bulletin pape

ab Initio MO Study on the Solvent Effect for S_N2 Type Nucleophilic Ring Opening of Aflatoxin B_1 8,9-Oxide

application/pdfArticledepartmental bulletin pape

Bilateral π-extension of an open-[60]fullerene in a helical manner

The conventional π-elongation of open-[60]fullerenes could only give unilaterally π-extended derivatives. Herein, we report the further π-elongation at another site to achieve bilateral π-elongation via a consecutive nucleophilic addition of 4, 5-dimethyl-o-phenylenediamine. The thus-formed π-extended open-[60]fullerene bears two-fold diaza[n]helicene (n = 5 and 6) motifs in its skeleton. The crystallographic analysis revealed the characteristic helicene–fullerene interactions with close contacts of 3.09 and 3.14 Å

On the Significance of the Gneissic Rocks Found as Xenoliths in Andesite on the Sangun Metamorphic Belt of Yamaguchi Prefecture

Gneissic rocks are found as xenoliths in the andesite of Mitakésan (Kimpôzan), 15 km to the north-northeast of Tokuyama City, Yamaguchi Prefecture. The xenoliths consist mainly of gneisses derived from basic rocks, containing hornblende, biotite, and plagioclase, in some specimens with clinopyroxene. Quartzo-feldspathic gneisses, consisting of biotite, plagioclase, and quartz, sometimes with garnet, pelitic gneiss, and non-foliated magmatites are also included. Judged from their rock association and mineral assemblage, they cannot be correlated to the gneisses either of the Ryôké or the Sangun metamorphic complex. The occurrence of gneiss xenoliths testifies to the presence of sialic layer, underlying the Sangun crystalline schists, which are characterized by the nature of the glaucophanitic metamorphism

A Former Late Loyalist in America Describes the Province of Upper Canada and the War of 18 12 (I)

寄稿論文Special Contributio