Geographic Tongue in Two Siblings

We report two illustrative cases of geographic tongue which occurred in 6- and 4-year-old sisters whose father had fissured tongue. The elder sister had mild atopic dermatitis and nail changes, but there was no family history suggestive of psoriasis. Histologically, the geographic tongue in the elder sister showed the same features as the oral lesions in pustular psoriasis. From a review of the literature we suggest that geographic tongue may be classified into two types, one that commonly occurs in atopies and another that develops as an oral manifestation of pustular psoriasis, although both types show similar histopathological features.</jats:p

Hypopigmented mycosis fungoides: An immunological investigation of tumor-infiltrating T cells

AbstractHypopigmented mycosis fungoides (HMF) is a clinical variant of MF presenting a good prognosis. In this report, we describe a case of HMF with dense infiltration of tumor-infiltrating leukocytes that bear several cytotoxic molecules, such as granulysin and T-cell intracellular antigen-1. In addition, our immunohistochemical study revealed that the ratio of Foxp3+ regulatory T cells to the total CD4+ cells is decreased in the lesional skin of HMF, compared with that of conventional MF. Our case suggested possible mechanisms for the hypopigmentation and good prognosis of this type of MF