Multi-exposure laser speckle contrast imaging using a high frame rate CMOS sensor with a field programmable gate array

A system has been developed in which multi-exposure Laser Speckle Contrast Imaging (LSCI) is implemented using a high frame rate CMOS imaging sensor chip. Processing is performed using a Field Programmable Gate Array (FPGA). The system allows different exposure times to be simulated by accumulating a number of short exposures. This has the advantage that the image acquisition time is limited by the maximum exposure time and that regulation of the illuminating light level is not required. This high frame rate camera has also been deployed to implement laser Doppler blood flow processing enabling direct comparison of multi-exposure laser speckle contrast imaging and Laser Doppler Imaging (LDI) to be carried out using the same experimental data. Results from a rotating diffuser indicate that both multi-exposure LSCI and LDI provide a linear response to changes in velocity. This cannot be obtained using single-exposure LSCI unless an appropriate model is used for correcting the response

Enhancing Monotonic Modeling with Spatio-Temporal Adaptive Awareness in Diverse Marketing

In the mobile internet era, the Online Food Ordering Service (OFOS) emerges as an integral component of inclusive finance owing to the convenience it brings to people. OFOS platforms offer dynamic allocation incentives to users and merchants through diverse marketing campaigns to encourage payments while maintaining the platforms' budget efficiency. Despite significant progress, the marketing domain continues to face two primary challenges: (i) how to allocate a limited budget with greater efficiency, demanding precision in predicting users' monotonic response (i.e. sensitivity) to incentives, and (ii) ensuring spatio-temporal adaptability and robustness in diverse marketing campaigns across different times and locations. To address these issues, we propose a Constrained Monotonic Adaptive Network (CoMAN) method for spatio-temporal perception within marketing pricing. Specifically, we capture spatio-temporal preferences within attribute features through two foundational spatio-temporal perception modules. To further enhance catching the user sensitivity differentials to incentives across varied times and locations, we design modules for learning spatio-temporal convexity and concavity as well as for expressing sensitivity functions. CoMAN can achieve a more efficient allocation of incentive investments during pricing, thus increasing the conversion rate and orders while maintaining budget efficiency. Extensive offline and online experimental results within our diverse marketing campaigns demonstrate the effectiveness of the proposed approach while outperforming the monotonic state-of-the-art method.Comment: 7 page

A single-chip CMOS pulse oximeter with on-chip lock-in detection

Pulse oximetry is a noninvasive and continuous method for monitoring the blood oxygen saturation level. This paper presents the design and testing of a single-chip pulse oximeter fabricated in a 0.35 µm CMOS process. The chip includes photodiode, transimpedance amplifier, analogue band-pass filters, analogue-to-digital converters, digital signal processor and LED timing control. The experimentally measured AC and DC characteristics of individual circuits including the DC output voltage of the transimpedance amplifier, transimpedance gain of the transimpedance amplifier, and the central frequency and bandwidth of the analogue band-pass filters, show a good match (within 1%) with the circuit simulations. With modulated light source and integrated lock-in detection the sensor effectively suppresses the interference from ambient light and 1/f noise. In a breath hold and release experiment the single chip sensor demonstrates consistent and comparable performance to commercial pulse oximetry devices with a mean of 1.2% difference. The single-chip sensor enables a compact and robust design solution that offers a route towards wearable devices for health monitorin

Full field laser doppler blood flow sensor

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Laser Doppler blood flow imaging using a CMOS imaging sensor with on-chip signal processing

The first fully integrated 2D CMOS imaging sensor with on-chip signal processing for applications in laser Doppler blood flow (LDBF) imaging has been designed and tested. To obtain a space efficient design over 64 × 64 pixels means that standard processing electronics used off-chip cannot be implemented. Therefore the analog signal processing at each pixel is a tailored design for LDBF signals with balanced optimization for signal-to-noise ratio and silicon area. This custom made sensor offers key advantages over conventional sensors, viz. the analog signal processing at the pixel level carries out signal normalization; the AC amplification in combination with an anti-aliasing filter allows analog-to-digital conversion with a low number of bits; low resource implementation of the digital processor enables on-chip processing and the data bottleneck that exists between the detector and processing electronics has been overcome. The sensor demonstrates good agreement with simulation at each design stage. The measured optical performance of the sensor is demonstrated using modulated light signals and in vivo blood flow experiments. Images showing blood flow changes with arterial occlusion and an inflammatory response to a histamine skin-prick demonstrate that the sensor array is capable of detecting blood flow signals from tissue