Impact of California's Transitional Kindergarten Program, 2013-14

Transitional kindergarten (TK)—the first year of a two-year kindergarten program for California children who turn 5 between September 2 and December 2—is intended to better prepare young five-year-olds for kindergarten and ensure a strong start to their educational career. To determine whether this goal is being achieved, American Institutes for Research (AIR) is conducting an evaluation of the impact of TK in California. The goal of this study is to measure the success of the program by determining the impact of TK on students' readiness for kindergarten in several areas. Using a rigorous regression discontinuity (RD) research design,1 we compared language, literacy, mathematics, executive function, and social-emotional skills at kindergarten entry for students who attended TK and for students who did not attend TK. Overall, we found that TK had a positive impact on students' kindergarten readiness in several domains, controlling for students' age differences. These effects are over and above the experiences children in the comparison group had the year before kindergarten, which for more than 80 percent was some type of preschool program

Review: The Journal of Dramaturgy, volume 20, 2009/2010

Contents include: Recognizing Toward a Dramaturgical Sensibility, Geoff Proehl, recipient of the 2009 ATHE Outstanding Book Award; Geoff Proehl\u27s Acceptance Speech, Association for Theatre in Higher Education Awards Ceremony August 10, 2009; Millennial Dramaturgy, A conversation about the new book Dramaturgy and Performance; Creating Sub/Text, Dramaturging the ReStaged Festival; Dramaturgy and Interdisciplinary Learning, A Case Study of Russian Theatre and Politics; Thinking about Theatre Photography; Theatre / Photography. Issue editors: D.J. Hopkins, Sydney Cheek O\u27Donnell, Lauren Beckhttps://soundideas.pugetsound.edu/lmdareview/1040/thumbnail.jp

“Have a little less, feel a lot better”: Mixed-method evaluation of an alcohol intervention

The aim of the mixed-methods study reported here was to evaluate the impact of a “gain-framed”, multimedia campaign to encourage heavier drinking men aged 45–64 years to drink less. Quantitative analyses were based on pre-intervention panel surveys of 3057 men in intervention regions and 500 in the control region, and post-intervention panel surveys of 1508 men in intervention regions and 219 in the control region. Qualitative analyses entailed thematic analysis of interviews with 14 men: five who had reduced their drinking after seeing the campaign, four who had considered reducing but did not, and five who did not consider changing. Interviews focused on men’s responses to the campaign, and their ideas for how to improve it. In quantitative analyses, the campaign was associated with significant changes in alcohol consumption, and significant increases in readiness to change and likelihood of using moderate drinking strategies. In qualitative analyses, men appreciated the friendly, non-threatening tone and that the message was straightforward, meaningful, achievable, and was gain-framed - i.e., emphasised the benefits of drinking less rather than the harms of drinking too much. However, the men who did not change their behaviour also identified several barriers to responding in ways encouraged by the message. It would be important to address their views of their drinking as not problematic, as pleasurable, and as socially expected, and also their sense of not feeling empowered to initiate or maintain behaviour change

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Spatial Variability in Meander Characteristics Within Modern Distributive Fluvial Systems (DFS)

Fluvial systems support a large variety of habitats, are important biogeochemical interfaces and act as conduits for delivering sediment and water to seas and oceans, as well as forming political boundaries. Fluvial sandstone deposits have the potential to act as reservoirs for carbon capture and storage and form the basis of geothermal and freshwater aquifers. Therefore, understanding the lithological variation of such deposits is critical to enhancing natural resource exploration and the sequestration of carbon from our atmosphere, in addition to providing insight into modern fluvial geomorphic processes. Recent research suggests that the abundance of subsurface fluvial deposits, such as meander deposits, have been significantly under-estimated within sedimentary basins. Therefore, meander deposits may form a bigger proportion of the rock record than previously thought. Research is required to better understand the spatial variation in gross-scale meander system characteristics, such as meander size and deposit architecture. This project aims to bridge these knowledge gaps by studying both modern and ancient meander deposits within a spatial context, by exploring how meander characteristics vary within and across two sedimentary basin types within different climatic settings. This will provide new quantification of the spatial variability expected within subsurface deposits and provide further understanding of fluvial geomorphic processes within sedimentary basins. The Meander Statistics Toolbox (MStaT - Ruben et al., 2021) was used alongside GIS and Google Earth Engine (GEE) to extract a range of meander characteristics (e.g. meander sinuosity, amplitude and migration rate) from modern DFS. Results from the Wood River DFS, Alaska, indicate that meander characteristics vary spatially, however not all characteristics follow a distinct downstream trend. The active channel width of the DFS is found to decrease downstream as expected based on literature (e.g. Nichols and Fisher, 2007; Weissman et al., 2010), however the channel belt width shows no clear downstream trend. Characteristics such as meander sinuosity and amplitudes are found to increase downstream to the medial zone of the DFS, and decrease towards the distal region. Meander migration rates follow a decreasing downstream trend from proximal to distal regions of the DFS. Comparison with the Bermejo DFS, Argentina will indicate how these compare to a different geographical and basin setting. The implications of this research are as follows: 1) to further understand modern fluvial geomorphic processes; 2) to provide new quantification for the variability expected within subsurface deposits and 3) to enhance understanding of the lithological variation of deposits for natural resource exploration and carbon sequestration