216 research outputs found

    Vergleichende Analysen des Proteoms ausgewählter renaler Neoplasien

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    Hauptversammlung und Internet

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    Das Internet bietet zahlreiche Möglichkeiten, um auf die Aktionäre im Rahmen der Hauptversammlung zuzugehen. Die Arbeit stellt die relevanten Techniken vor und untersucht deren Zulässigkeit bei der Vorbereitung und Durchführung des Aktionärstreffens. Sie orientiert sich dabei am zeitlichen Ablauf der Hauptversammlung und erläutert, worauf beim Einsatz von E-Mail, World Wide Web, Hyperlinks, Audio- und Video-Übertragungen zu achten ist. Bewertungsmaßstab sind auch Corporate Governance-Gesichtspunkte, so daß der rechtlichen Betrachtung stets eine betriebswirtschaftliche folgt. Die Dissertation ist somit gleichzeitig ein Praxishandbuch für sämtliche Fragen zum Internet-Einsatz auf der Hauptversammlung

    Vergleichende Analysen des Proteoms ausgewählter renaler Neoplasien

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    Quantum Walk Laser

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    Synthetic lattices in photonics enable the exploration of light states in new dimensions, transcending phenomena common only to physical space. We propose and demonstrate a Quantum Walk Laser in synthetic frequency space formed by externally modulating a ring-shaped semiconductor laser with ultrafast recovery times. In this device, the initially ballistic quantum walk does not dissipate into low supermode states of the synthetic lattice; instead, thanks to the fast-gain nonlinearity of our quantum cascade laser active material, the state stabilizes in a broad frequency comb, unlocking the full potential of the lattice. This device produces a low-noise, nearly-flat broadband comb (reaching 100 cm1^{-1} bandwidth), well predicted by our models. The proposed Quantum Walk Laser offers a promising platform to generate broadband, tunable and stable frequency combs.Comment: 9 pages, 4 figure

    Altered Phenotypic Responses of Asexual Arctic Daphnia After 10 Years of Rapid Climate Change

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    Understanding the fates of organisms and ecosystems under global change requires consideration of the organisms' rapid adaptation potential. In the Arctic, the recent temperature increase strongly impacts freshwater ecosystems which are important sentinels for climate change. However, a mechanistic understanding of the adaptive capacity of their key zooplankton grazers, among them polyploid, obligate parthenogenetic Daphnia, is lacking. Theory suggests low adaptation potential of asexual animals, yet examples exist of asexuals persisting through marked environmental changes. Here, we studied asexual Daphnia pulicaria from a meromictic lake in South-West Greenland. Its oxycline hosts purple sulfur bacteria (PSB), a potential food source for Daphnia. We tested two key phenotypic traits: (1) thermal tolerance as a response to rapid regional warming and (2) hypoxia tolerance tied to grazing of PSB in the hypoxic/anoxic transition zone. To assess Daphnia's adaptive capacity, we resurrected Daphnia from dormant eggs representing a historical subpopulation from 2011, sampled modern subpopulation representatives in 2022, and measured phenotypic variation of thermal (time to immobilization—Timm) and hypoxia tolerance (respiration rate and critical oxygen limit—Pcrit) in clonal lineages of both subpopulations. Whole genome sequencing of the tested clonal lineages identified three closely related genetic clusters, one with clones from both subpopulations and two unique to each subpopulation. We observed significantly lower Timm and a trend for higher Pcrit and respiration rates in the modern subpopulation, indicating a lower tolerance to both high temperature and hypoxia in comparison with the historical subpopulation. As these two traits share common physiological mechanisms, the observed phenotypic divergence might be driven by a relaxed selection pressure on hypoxia tolerance linked to variation in PSB abundance. Our results, while contrary to our expectation of higher thermal tolerance in the modern subpopulation, provide evidence for phenotypic change within a decade in this asexual Daphnia population

    Quench dynamics of Wannier-Stark states in an active synthetic photonic lattice

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    Photonic emulators have facilitated the investigation of numerous solid-state phenomena and have contributed to the development of optical devices inspired by quantum mechanics. Although current photonic emulators are constrained to bosonic behavior with local interactions, the utilization of active synthetic lattices holds promise for surpassing these limitations. In this study, we propose employing the modulated ring fast-gain laser as a foundation for emulating quench dynamics within a synthetic lattice that conforms to equal density filling of its reciprocal space. To illustrate the effectiveness of this emulation platform, we subject a dispersed Wannier-Stark ladder to quenching and directly observe oscillations, enabled by the fast-gain, along with their coherent stabilization to a single Wannier stark state. These coherent dynamics stem directly from our lasers liquid state of light, a characteristic resulting from fast-gain and explained by the rapid decay of fluctuations occurring on the system's shortest timescale. Additionally, by adequately biasing the lattice through detuning the modulation from the cavity resonance, this process supports oscillatory dynamics within the synthetic space

    Optimization Technique for Electric Bus Fleet Schedules with a-Priori Trip Disaggregation

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    Electric vehicles represent a great opportunity to electrify the public transportation sector, and thereby mitigate greenhouse gas emissions and noise pollution among others. Due to the limited range of electric buses compared to their internal combustion engine counterparts, the scheduling process has to be rethought. A fleet operator has to decide between different charging strategies such as depot-charging, opportunity-charging, or a combination of both. The existence of different vehicle types, e. g., regarding battery capacity and passenger capacity, further complicates the matter. We introduce a multiple vehicle type scheduling problem with partial charging (MVTSP-PC) that can optimize existing fleet schedules. Our approach is based on the disaggregation of the existing bus schedule. Then, with an exact solution approach using mixed-integer linear programming and route restriction strategies we identify optimal schedules while considering computational resources. With the presented approach bus schedules for whole weeks can be efficiently re-adapted. The approach designs the optimal schedule on a daily basis, and subsequently uses a heuristic approach for the vehicle-to-route assignment when concatenating the days

    Nonradiative lifetime extraction using power-dependent relative photoluminescence of III-V semiconductor double-heterostructures

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    A power-dependent relative photoluminescence measurement method is developed for double-heterostructures composed of III-V semiconductors. Analyzing the data yields insight into the radiative efficiency of the absorbing layer as a function of laser intensity. Four GaAs samples of different thicknesses are characterized, and the measured data are corrected for dependencies of carrier concentration and photon recycling. This correction procedure is described and discussed in detail in order to determine the material's Shockley-Read-Hall lifetime as a function of excitation intensity. The procedure assumes 100% internal radiative efficiency under the highest injection conditions, and we show this leads to less than 0.5% uncertainty. The resulting GaAs material demonstrates a 5.7 ± 0.5 ns nonradiative lifetime across all samples of similar doping (2–3 × 10^(17) cm^(−3)) for an injected excess carrier concentration below 4 × 10^(12) cm^(−3). This increases considerably up to longer than 1 μs under high injection levels due to a trap saturation effect. The method is also shown to give insight into bulk and interface recombination

    Decline in the number of patients with meningitis in German hospitals during the COVID-19 pandemic

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    BACKGROUND AND OBJECTIVES: In 2020, a wide range of hygiene measures was implemented to mitigate infections caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In consequence, pulmonary infections due to other respiratory pathogens also decreased. Here, we evaluated the number of bacterial and viral meningitis and encephalitis cases during the coronavirus disease 2019 (COVID-19) pandemic. METHODS: In a multicentre retrospective analysis of data from January 2016 until December 2020, numbers of patients diagnosed with bacterial meningitis and other types of CNS infections (such as viral meningitis and encephalitis) at 26 German hospitals were studied. Furthermore, the number of common meningitis-preceding ear-nose-throat infections (sinusitis, mastoiditis and otitis media) was evaluated. RESULTS: Compared to the previous years, the total number of patients diagnosed with pneumococcal meningitis was reduced (n = 64 patients/year in 2020 vs. n = 87 to 120 patients/year between 2016 and 2019, all p < 0.05). Additionally, the total number of patients diagnosed with otolaryngological infections was significantly lower (n = 1181 patients/year in 2020 vs. n = 1525 to 1754 patients/year between 2016 and 2019, all p < 0.001). We also observed a decline in viral meningitis and especially enterovirus meningitis (n = 25 patients/year in 2020 vs. n = 97 to 181 patients/year between 2016 and 2019, all p < 0.001). DISCUSSION: This multicentre retrospective analysis demonstrates a decline in the number of patients treated for viral and pneumococcal meningitis as well as otolaryngological infections in 2020 compared to previous years. Since the latter often precedes pneumococcal meningitis, this may point to the significance of the direct spread of pneumococci from an otolaryngological focus such as mastoiditis to the brain as one important pathophysiological route in the development of pneumococcal meningitis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00415-022-11034-w
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