Numerical efficiency calibration of in vivo measurement systems : Monte Carlo simulations of in vivo measurement scenarios for the detection of incorporated radionuclides, including validation, analysis of efficiency-sensitive parameters and customized anthropomorphic voxel models

Monte Carlo radiation transport codes were used with virtual models of in vivo measurement equipment. Software was coded to handle memory intensive anthropomorphic voxel models for simulation of measurement scenarios. Tools, methods and models have been validated. Various parameters have been investigated for their sensitivity. Methods based on image registration techniques have been developed to transform existing human models to match with an individual test person

Gastrointestinale Erkrankungen, die in Folge von unterwünschten Arzneimittelereignissen (UAE) zur Krankenhausaufnahme führten

Unerwünschte Arzneimittelereignisse treten wesentlich häufiger auf als allgemein angenommen wird. Besonders ist davon der Gastrointestinaltrakt betroffen. Eine Untersuchung in den Chirurgischen Kliniken der Universität Jena hat gezeigt, dass 0,7% der Krankenhausaufnahmen anhand gastrointestinaler unerwünschter Arzneimittelereignisse begründet werden konnten. Mehr als die Hälfte der Fälle konnten als vermeidbar eingestuft werden. Besonders betroffen waren Patienten mit einem hohen Lebensalter. Als am häufigsten ursächliche Medikamente wurden die seit Jahrzehnten auf dem Markt bestehenden Mittel ASS und NSAR identifiziert

The future is now: how future self-continuity affects behavioral intentions towards climate change

Public concern about the environment has been declining since the 1990s, despite increased urgency from scientists to begin mitigation efforts as soon as possible (Balakrishnan, 2018). This begs the question: how do we increase care and concern over climate change and, ultimately, influence human behaviors to mitigate the current environmental crisis? We sought to determine if behavioral intentions towards climate change mitigation could be influenced by an individual's feeling of connectedness to their future self, or future self-continuity. The goal of Studies 1 and 2 were to manipulate future self-continuity by combining methods from Truelove Parks (2012) and Hershfield et al. (2011) in order increase participant.s intentions to engage in environmentally conscious behaviors. Results from both studies indicate that the future self-continuity manipulation had no significant effect on environmental behavioral intentions. Despite the nonsignificant results, we were able to assemble a reliable intentions measure of feasible environmental behaviors.https://doi.org/10.46569/20.500.12680/xg94hv72

The immune system as a foundation for immunologic therapy and hematologic malignancies: a historical perspective.

In this review we aim to provide a historical overview of the immunotherapeutic approaches which have been developed for the treatment of hematological malignancies. After briefly summarizing the development of the theory of cancer immune surveillance, we describe how initial studies discovering the efficacy of the immune-mediated graft-versus-tumor effects after allogeneic hematopoietic cell transplantation led to new transplantation approaches (termed non-myeloablative transplantation) relying almost exclusively on graft-versus-tumor effects for tumor eradication. We then summarize important steps in the development of tumor vaccines and autologous adoptive immunotherapy in patients with hematological malignancies. Finally, we describe historical discoveries leading to the recent success with monoclonal antibodies as treatment for lymphomas, chronic lymphocytic leukemia, and acute myeloid leukemia

Бухгалтерский учет и анализ финансовых результатов деятельности торговой организации (на примере ООО «Стандарт»)

Объект исследования – общество с ограниченной ответственностью "Стандарт". Актуальность работы обусловлена значимостью рассмотрения вопроса о сущности, учете и анализе финансовых результатов экономического субъекта. Цель работы: анализ финансовых результатов и разработка рекомендаций по улучшению финансового состояния в исследуемой торговой организации. Задачи: изучение теоретических аспектов учета и анализа финансовых результатов; исследование и оценка организации учета финансовых результатов, формирования, распределения и использования прибыли в ООО "Стандарт"; анализ состава, структуры и динамики финансовых результатов; анализ рентабельности; выполнение факторного и маржинального анализа прибыли; разработка рекомендаций по улучшению финансового состояния и оптимизации прибыли.The object of the study-a limited liability company "Standard". The relevance of the work is due to the importance of consideration of the nature, accounting and analysis of the financial results of the economic entity. The purpose of the work: analysis of financial results and development of recommendations to improve the financial condition in the studied trade organization. Objectives: the study of theoretical aspects of accounting and analysis of financial results; research and evaluation of the organization of accounting of financial results, the formation, distribution and use of profits in LLC "Standard"; analysis of the composition, structure and dynamics of financial results; analysis of profitability; implementation of factor and margin analysis of profits

Scale-Adaptive Texture Classification

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CD4+CD25highCD127low Regulatory T Cells in Peripheral Blood Are Not an Independent Factor for Chronic Graft-versus-Host Disease after Allogeneic Stem Cell Transplantation

Background. The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cells (Treg) are a subset of CD4+ T-helper cells believed to maintain tolerance after HSCT. It remains unclear whether low peripheral blood Treg have an impact on the risk for acute (aGVHD) and chronic GVHD (cGVHD). Methods. In this paper we enumerated the CD4+CD25highCD127low Treg in the peripheral blood of 84 patients after at least 150 days from HSCT and in 20 healthy age-matched controls. Results. Although similar mean lymphocyte counts were found in patients and controls, CD3+CD4+ T-cell counts were significantly lower in patients. Patients also had significantly lower Treg percentages among lymphocytes as compared to controls. Patients with cGVHD had even higher percentages of Treg if compared to patients without cGVHD. In multivariate analysis, Treg percentages were not an independent factor for cGVHD. Conclusions. This paper did not show a relation between deficient peripheral blood Treg and cGVHD, therefore cGVHD does not seem to occur as a result of peripheral Treg paucity

Aggregation of full length immunoglobulin light chains from AL amyloidosis patients is remodeled by epigallocatechin-3-gallate

Intervention into amyloid deposition with anti-amyloid agents like the polyphenol Epigallocatechin-3-gallate (EGCG) is emerging as an experimental secondary treatment strategy in systemic light chain amyloidosis (AL). In both AL and Multiple Myeloma (MM), soluble immunoglobulin light chains (LC) are produced by clonal plasma cells, but only in AL they form amyloid deposits in vivo. We investigated the amyloid formation of patient-derived LC and their susceptibility to EGCG in vitro to probe commonalities and systematic differences in their assembly mechanisms. We isolated nine LC from urine of AL and MM patients. We quantified their thermodynamic stabilities, and monitored their aggregation under physiological conditions by ThT fluorescence, light scattering, SDS-stability and atomic force microscopy. LC from all patients formed amyloid-like aggregates, albeit with individually different kinetics. LC existed as dimers, ~50% of which were linked by disulfide bridges. Our results suggest that cleavage into LC monomers is required for efficient amyloid formation. The kinetics of AL LC displayed a transition point in concentration dependence, which MM LC lacked. The lack of concentration dependence of MM LC aggregation kinetics suggests that conformational change of the light chain is rate-limiting for these proteins. Aggregation kinetics displayed two distinct phases, which corresponded to the formation of oligomers and amyloid fibrils, respectively. EGCG specifically inhibited the second aggregation phase and induced the formation of SDS-stable, non-amyloid LC aggregates. Our data suggest that EGCG intervention does not depend on the individual LC sequence and is similar to the mechanism observed for amyloid-{beta} and {alpha}-synuclein